Mesoporous superparamagnetic cobalt ferrite nanoclusters: Synthesis, characterization and application in drug delivery
•L-Arginine coated CoFe2O4 nanoclusters with mesoporous structure.•The nanoclusters exhibited superparamagnetic behavior and negligible cytotoxicity.•High drug loading capacity and pH-responsive release behavior. In this contribution, an amino acid of L-Arginine coated cobalt ferrite (CoFe2O4) nanoc...
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| Veröffentlicht in: | Journal of magnetism and magnetic materials 2020-03, Vol.498, p.166222, Article 166222 |
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| container_title | Journal of magnetism and magnetic materials |
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| creator | Shi, Zhimin Zeng, Yingzhe Chen, Xin Zhou, Fei Zheng, Liyun Wang, Guangshuo Gao, Jie Ma, Yingying Zheng, Lianhong Fu, Bin Yu, Ruitao |
| description | •L-Arginine coated CoFe2O4 nanoclusters with mesoporous structure.•The nanoclusters exhibited superparamagnetic behavior and negligible cytotoxicity.•High drug loading capacity and pH-responsive release behavior.
In this contribution, an amino acid of L-Arginine coated cobalt ferrite (CoFe2O4) nanoclusters with mesoporous structure were synthesized via a facile solvothermal strategy. The morphology, structure and properties of bare CoFe2O4 and L-Arg-coated CoFe2O4 nanoclusters were characterized in detail by SEM, TEM, XRD, XPS, TGA, BET and SQUID. It was found that these products exhibited a well-defined clusters-like morphology and a uniform size distribution with an average diameter of 103.6 nm. The as-prepared superparamagnetic CoFe2O4 nanoclusters with mesoporous structure and negligible cytotoxicity could be utilized as an effective drug delivery for doxorubicin hydrochloride (DOX). The drug loading capacity and the release behavior in vitro of DOX from L-Arg-coated CoFe2O4 nanoclusters at different pH values (4.0 and 7.4) were investigated. The results showed that the developed drug delivery system exhibited a high drug loading capacity and a pH-sensitive drug release behavior. |
| doi_str_mv | 10.1016/j.jmmm.2019.166222 |
| format | Article |
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In this contribution, an amino acid of L-Arginine coated cobalt ferrite (CoFe2O4) nanoclusters with mesoporous structure were synthesized via a facile solvothermal strategy. The morphology, structure and properties of bare CoFe2O4 and L-Arg-coated CoFe2O4 nanoclusters were characterized in detail by SEM, TEM, XRD, XPS, TGA, BET and SQUID. It was found that these products exhibited a well-defined clusters-like morphology and a uniform size distribution with an average diameter of 103.6 nm. The as-prepared superparamagnetic CoFe2O4 nanoclusters with mesoporous structure and negligible cytotoxicity could be utilized as an effective drug delivery for doxorubicin hydrochloride (DOX). The drug loading capacity and the release behavior in vitro of DOX from L-Arg-coated CoFe2O4 nanoclusters at different pH values (4.0 and 7.4) were investigated. The results showed that the developed drug delivery system exhibited a high drug loading capacity and a pH-sensitive drug release behavior.</description><identifier>ISSN: 0304-8853</identifier><identifier>EISSN: 1873-4766</identifier><identifier>DOI: 10.1016/j.jmmm.2019.166222</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Cobalt ferrite ; Cobalt ferrites ; Doxorubicin ; Drug delivery ; Drug delivery systems ; L-Arginine ; Mesoporous ; Morphology ; Nanoclusters ; Size distribution ; Superparamagnetic ; Toxicity ; X ray photoelectron spectroscopy</subject><ispartof>Journal of magnetism and magnetic materials, 2020-03, Vol.498, p.166222, Article 166222</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright Elsevier BV Mar 15, 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-7510242d30ec9008e2de2e43fa43c3869d87af55ec55d5b37f1b747c5ae4f8dd3</citedby><cites>FETCH-LOGICAL-c328t-7510242d30ec9008e2de2e43fa43c3869d87af55ec55d5b37f1b747c5ae4f8dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jmmm.2019.166222$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids></links><search><creatorcontrib>Shi, Zhimin</creatorcontrib><creatorcontrib>Zeng, Yingzhe</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Zhou, Fei</creatorcontrib><creatorcontrib>Zheng, Liyun</creatorcontrib><creatorcontrib>Wang, Guangshuo</creatorcontrib><creatorcontrib>Gao, Jie</creatorcontrib><creatorcontrib>Ma, Yingying</creatorcontrib><creatorcontrib>Zheng, Lianhong</creatorcontrib><creatorcontrib>Fu, Bin</creatorcontrib><creatorcontrib>Yu, Ruitao</creatorcontrib><title>Mesoporous superparamagnetic cobalt ferrite nanoclusters: Synthesis, characterization and application in drug delivery</title><title>Journal of magnetism and magnetic materials</title><description>•L-Arginine coated CoFe2O4 nanoclusters with mesoporous structure.•The nanoclusters exhibited superparamagnetic behavior and negligible cytotoxicity.•High drug loading capacity and pH-responsive release behavior.
In this contribution, an amino acid of L-Arginine coated cobalt ferrite (CoFe2O4) nanoclusters with mesoporous structure were synthesized via a facile solvothermal strategy. The morphology, structure and properties of bare CoFe2O4 and L-Arg-coated CoFe2O4 nanoclusters were characterized in detail by SEM, TEM, XRD, XPS, TGA, BET and SQUID. It was found that these products exhibited a well-defined clusters-like morphology and a uniform size distribution with an average diameter of 103.6 nm. The as-prepared superparamagnetic CoFe2O4 nanoclusters with mesoporous structure and negligible cytotoxicity could be utilized as an effective drug delivery for doxorubicin hydrochloride (DOX). The drug loading capacity and the release behavior in vitro of DOX from L-Arg-coated CoFe2O4 nanoclusters at different pH values (4.0 and 7.4) were investigated. The results showed that the developed drug delivery system exhibited a high drug loading capacity and a pH-sensitive drug release behavior.</description><subject>Cobalt ferrite</subject><subject>Cobalt ferrites</subject><subject>Doxorubicin</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>L-Arginine</subject><subject>Mesoporous</subject><subject>Morphology</subject><subject>Nanoclusters</subject><subject>Size distribution</subject><subject>Superparamagnetic</subject><subject>Toxicity</subject><subject>X ray photoelectron spectroscopy</subject><issn>0304-8853</issn><issn>1873-4766</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMouH78AU8Br3bNR9NmxYuIX6B4UM8hm0w1pU1qki6sv94u9expmOF9ZoYHoTNKlpTQ6rJdtn3fLxmhqyWtKsbYHlpQWfOirKtqHy0IJ2UhpeCH6CillhBCS1kt0OYFUhhCDGPCaRwgDjrqXn96yM5gE9a6y7iBGF0G7LUPphtThpiu8NvW5y9ILl1g8zVRZhq7H51d8Fh7i_UwdM7MvfPYxvETW-jcBuL2BB00uktw-leP0cf93fvtY_H8-vB0e_NcGM5kLmpBCSuZ5QTMihAJzAKDkje65IbLamVlrRshwAhhxZrXDV3XZW2EhrKR1vJjdD7vHWL4HiFl1YYx-umkYlzwiopVLaYUm1MmhpQiNGqIrtdxqyhRO7-qVTu_audXzX4n6HqGYPp_4yCqZBx4A9ZFMFnZ4P7DfwEhZ4c4</recordid><startdate>20200315</startdate><enddate>20200315</enddate><creator>Shi, Zhimin</creator><creator>Zeng, Yingzhe</creator><creator>Chen, Xin</creator><creator>Zhou, Fei</creator><creator>Zheng, Liyun</creator><creator>Wang, Guangshuo</creator><creator>Gao, Jie</creator><creator>Ma, Yingying</creator><creator>Zheng, Lianhong</creator><creator>Fu, Bin</creator><creator>Yu, Ruitao</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20200315</creationdate><title>Mesoporous superparamagnetic cobalt ferrite nanoclusters: Synthesis, characterization and application in drug delivery</title><author>Shi, Zhimin ; Zeng, Yingzhe ; Chen, Xin ; Zhou, Fei ; Zheng, Liyun ; Wang, Guangshuo ; Gao, Jie ; Ma, Yingying ; Zheng, Lianhong ; Fu, Bin ; Yu, Ruitao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-7510242d30ec9008e2de2e43fa43c3869d87af55ec55d5b37f1b747c5ae4f8dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cobalt ferrite</topic><topic>Cobalt ferrites</topic><topic>Doxorubicin</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>L-Arginine</topic><topic>Mesoporous</topic><topic>Morphology</topic><topic>Nanoclusters</topic><topic>Size distribution</topic><topic>Superparamagnetic</topic><topic>Toxicity</topic><topic>X ray photoelectron spectroscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Zhimin</creatorcontrib><creatorcontrib>Zeng, Yingzhe</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Zhou, Fei</creatorcontrib><creatorcontrib>Zheng, Liyun</creatorcontrib><creatorcontrib>Wang, Guangshuo</creatorcontrib><creatorcontrib>Gao, Jie</creatorcontrib><creatorcontrib>Ma, Yingying</creatorcontrib><creatorcontrib>Zheng, Lianhong</creatorcontrib><creatorcontrib>Fu, Bin</creatorcontrib><creatorcontrib>Yu, Ruitao</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of magnetism and magnetic materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Zhimin</au><au>Zeng, Yingzhe</au><au>Chen, Xin</au><au>Zhou, Fei</au><au>Zheng, Liyun</au><au>Wang, Guangshuo</au><au>Gao, Jie</au><au>Ma, Yingying</au><au>Zheng, Lianhong</au><au>Fu, Bin</au><au>Yu, Ruitao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mesoporous superparamagnetic cobalt ferrite nanoclusters: Synthesis, characterization and application in drug delivery</atitle><jtitle>Journal of magnetism and magnetic materials</jtitle><date>2020-03-15</date><risdate>2020</risdate><volume>498</volume><spage>166222</spage><pages>166222-</pages><artnum>166222</artnum><issn>0304-8853</issn><eissn>1873-4766</eissn><abstract>•L-Arginine coated CoFe2O4 nanoclusters with mesoporous structure.•The nanoclusters exhibited superparamagnetic behavior and negligible cytotoxicity.•High drug loading capacity and pH-responsive release behavior.
In this contribution, an amino acid of L-Arginine coated cobalt ferrite (CoFe2O4) nanoclusters with mesoporous structure were synthesized via a facile solvothermal strategy. The morphology, structure and properties of bare CoFe2O4 and L-Arg-coated CoFe2O4 nanoclusters were characterized in detail by SEM, TEM, XRD, XPS, TGA, BET and SQUID. It was found that these products exhibited a well-defined clusters-like morphology and a uniform size distribution with an average diameter of 103.6 nm. The as-prepared superparamagnetic CoFe2O4 nanoclusters with mesoporous structure and negligible cytotoxicity could be utilized as an effective drug delivery for doxorubicin hydrochloride (DOX). The drug loading capacity and the release behavior in vitro of DOX from L-Arg-coated CoFe2O4 nanoclusters at different pH values (4.0 and 7.4) were investigated. The results showed that the developed drug delivery system exhibited a high drug loading capacity and a pH-sensitive drug release behavior.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><doi>10.1016/j.jmmm.2019.166222</doi></addata></record> |
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| subjects | Cobalt ferrite Cobalt ferrites Doxorubicin Drug delivery Drug delivery systems L-Arginine Mesoporous Morphology Nanoclusters Size distribution Superparamagnetic Toxicity X ray photoelectron spectroscopy |
| title | Mesoporous superparamagnetic cobalt ferrite nanoclusters: Synthesis, characterization and application in drug delivery |
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