Hydrogen Peroxide and Glutathione Dual Redox‐Responsive Nanoparticles for Controlled DOX Release
Polymer nanoparticulate drug delivery systems that respond to reactive oxygen species (ROS) and glutathione (GSH) simultaneously at biologically relevant levels hold great promise to improve the therapeutic efficacy to cancer cells with reduced side effects of chemo drugs. Herein, a novel redox dual...
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| Veröffentlicht in: | Macromolecular bioscience 2020-02, Vol.20 (2), p.e1900331-n/a |
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| creator | Chen, Runhai Ma, Zhifang Xiang, Zehong Xia, Yu Shi, Qiang Wong, Shing‐Chung Yin, Jinghua |
| description | Polymer nanoparticulate drug delivery systems that respond to reactive oxygen species (ROS) and glutathione (GSH) simultaneously at biologically relevant levels hold great promise to improve the therapeutic efficacy to cancer cells with reduced side effects of chemo drugs. Herein, a novel redox dual‐responsive amphiphilic block copolymer (ABP) that consists of a hydrophilic poly (ethylene oxide) block and a hydrophobic block bearing disulfide linked phenylboronic ester group as pendant is synthesized, and the DOX loaded nanoparticles (BSN‐DOX) based on ABPs with varied hydrophobic block length are fabricated for DOX delivery. The self‐immolative leaving reaction of phenylboronic ester triggered by extracellular ROS and the cleavage of disulfide linkages induced by intracellular GSH both lead to rapid DOX release from BSN‐DOX, resulting in an on‐demand DOX release. Moreover, BSN‐DOX show better tumor inhibition and lower side effects in vivo compared with free drug.
A novel redox dual‐responsive amphiphilic block copolymer that consists of a hydrophilic poly (ethylene oxide) block and a hydrophobic block bearing disulfide linked phenylboronic ester group as pendant is synthesized for DOX delivery. A controlled DOX release that is triggered sequentially by extracellular reactive oxygen species and intracellular glutathione of cancer cells, and the selective toxicity to tumor cells are obtained. |
| doi_str_mv | 10.1002/mabi.201900331 |
| format | Article |
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A novel redox dual‐responsive amphiphilic block copolymer that consists of a hydrophilic poly (ethylene oxide) block and a hydrophobic block bearing disulfide linked phenylboronic ester group as pendant is synthesized for DOX delivery. A controlled DOX release that is triggered sequentially by extracellular reactive oxygen species and intracellular glutathione of cancer cells, and the selective toxicity to tumor cells are obtained.</description><identifier>ISSN: 1616-5187</identifier><identifier>EISSN: 1616-5195</identifier><identifier>DOI: 10.1002/mabi.201900331</identifier><identifier>PMID: 31856396</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Animals ; Block copolymers ; cancer ; Delayed-Action Preparations - chemistry ; Delayed-Action Preparations - pharmacokinetics ; Delayed-Action Preparations - pharmacology ; Disulfide bonds ; DOX ; Doxorubicin - chemistry ; Doxorubicin - pharmacokinetics ; Doxorubicin - pharmacology ; Drug Carriers - chemistry ; Drug Carriers - pharmacokinetics ; Drug Carriers - pharmacology ; Drug delivery ; Drug delivery systems ; dual‐responsive ; Ethylene oxide ; Female ; Glutathione ; Glutathione - metabolism ; HeLa Cells ; Humans ; Hydrogen peroxide ; Hydrogen Peroxide - metabolism ; Hydrophobicity ; Mice ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - therapeutic use ; Neoplasms, Experimental - drug therapy ; Neoplasms, Experimental - metabolism ; Neoplasms, Experimental - pathology ; Oxidation-Reduction ; Polymers ; Reactive oxygen species ; Side effects ; Xenograft Model Antitumor Assays</subject><ispartof>Macromolecular bioscience, 2020-02, Vol.20 (2), p.e1900331-n/a</ispartof><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4101-650e38981c163466763aecfe55a018933e660d782e866586bee9215200dd0e5f3</citedby><cites>FETCH-LOGICAL-c4101-650e38981c163466763aecfe55a018933e660d782e866586bee9215200dd0e5f3</cites><orcidid>0000-0003-4431-4434</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmabi.201900331$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmabi.201900331$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31856396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Runhai</creatorcontrib><creatorcontrib>Ma, Zhifang</creatorcontrib><creatorcontrib>Xiang, Zehong</creatorcontrib><creatorcontrib>Xia, Yu</creatorcontrib><creatorcontrib>Shi, Qiang</creatorcontrib><creatorcontrib>Wong, Shing‐Chung</creatorcontrib><creatorcontrib>Yin, Jinghua</creatorcontrib><title>Hydrogen Peroxide and Glutathione Dual Redox‐Responsive Nanoparticles for Controlled DOX Release</title><title>Macromolecular bioscience</title><addtitle>Macromol Biosci</addtitle><description>Polymer nanoparticulate drug delivery systems that respond to reactive oxygen species (ROS) and glutathione (GSH) simultaneously at biologically relevant levels hold great promise to improve the therapeutic efficacy to cancer cells with reduced side effects of chemo drugs. Herein, a novel redox dual‐responsive amphiphilic block copolymer (ABP) that consists of a hydrophilic poly (ethylene oxide) block and a hydrophobic block bearing disulfide linked phenylboronic ester group as pendant is synthesized, and the DOX loaded nanoparticles (BSN‐DOX) based on ABPs with varied hydrophobic block length are fabricated for DOX delivery. The self‐immolative leaving reaction of phenylboronic ester triggered by extracellular ROS and the cleavage of disulfide linkages induced by intracellular GSH both lead to rapid DOX release from BSN‐DOX, resulting in an on‐demand DOX release. Moreover, BSN‐DOX show better tumor inhibition and lower side effects in vivo compared with free drug.
A novel redox dual‐responsive amphiphilic block copolymer that consists of a hydrophilic poly (ethylene oxide) block and a hydrophobic block bearing disulfide linked phenylboronic ester group as pendant is synthesized for DOX delivery. A controlled DOX release that is triggered sequentially by extracellular reactive oxygen species and intracellular glutathione of cancer cells, and the selective toxicity to tumor cells are obtained.</description><subject>Animals</subject><subject>Block copolymers</subject><subject>cancer</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Delayed-Action Preparations - pharmacokinetics</subject><subject>Delayed-Action Preparations - pharmacology</subject><subject>Disulfide bonds</subject><subject>DOX</subject><subject>Doxorubicin - chemistry</subject><subject>Doxorubicin - pharmacokinetics</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - pharmacokinetics</subject><subject>Drug Carriers - pharmacology</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>dual‐responsive</subject><subject>Ethylene oxide</subject><subject>Female</subject><subject>Glutathione</subject><subject>Glutathione - metabolism</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Hydrogen peroxide</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>Hydrophobicity</subject><subject>Mice</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - therapeutic use</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>Neoplasms, Experimental - metabolism</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Oxidation-Reduction</subject><subject>Polymers</subject><subject>Reactive oxygen species</subject><subject>Side effects</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1616-5187</issn><issn>1616-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFPwjAYhhujEUSvHk0Tz8N2pV13RFAgQTFEE29Lt37TkbHOdlO4-RP8jf4SR0A8eup3eN6nyYPQOSVdSoh_tVRx1vUJDQlhjB6gNhVUeJyG_HB_y6CFTpxbEEIDGfrHqMWo5IKFoo3i8Vpb8wIFfgBrVpkGrAqNR3ldqeo1MwXgYa1yPAdtVt-fX3NwpSlc9g74XhWmVLbKkhwcTo3FA1NU1uQ5aDycPTebHJSDU3SUqtzB2e7toKfbm8fB2JvORpNBf-olPUqoJzgBJkNJEypYT4hAMAVJCpwrQmXIGAhBdCB9kEJwKWKA0KfcJ0RrAjxlHXS59ZbWvNXgqmhhals0X0Y-44z3mhFvqO6WSqxxzkIalTZbKruOKIk2SaNN0miftBlc7LR1vAS9x38bNkC4BT6yHNb_6KK7_vXkT_4DwhCCyg</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Chen, Runhai</creator><creator>Ma, Zhifang</creator><creator>Xiang, Zehong</creator><creator>Xia, Yu</creator><creator>Shi, Qiang</creator><creator>Wong, Shing‐Chung</creator><creator>Yin, Jinghua</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0003-4431-4434</orcidid></search><sort><creationdate>202002</creationdate><title>Hydrogen Peroxide and Glutathione Dual Redox‐Responsive Nanoparticles for Controlled DOX Release</title><author>Chen, Runhai ; Ma, Zhifang ; Xiang, Zehong ; Xia, Yu ; Shi, Qiang ; Wong, Shing‐Chung ; Yin, Jinghua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4101-650e38981c163466763aecfe55a018933e660d782e866586bee9215200dd0e5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Block copolymers</topic><topic>cancer</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Delayed-Action Preparations - pharmacokinetics</topic><topic>Delayed-Action Preparations - pharmacology</topic><topic>Disulfide bonds</topic><topic>DOX</topic><topic>Doxorubicin - chemistry</topic><topic>Doxorubicin - pharmacokinetics</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - pharmacokinetics</topic><topic>Drug Carriers - pharmacology</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>dual‐responsive</topic><topic>Ethylene oxide</topic><topic>Female</topic><topic>Glutathione</topic><topic>Glutathione - metabolism</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Hydrogen peroxide</topic><topic>Hydrogen Peroxide - metabolism</topic><topic>Hydrophobicity</topic><topic>Mice</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - therapeutic use</topic><topic>Neoplasms, Experimental - drug therapy</topic><topic>Neoplasms, Experimental - metabolism</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Oxidation-Reduction</topic><topic>Polymers</topic><topic>Reactive oxygen species</topic><topic>Side effects</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Runhai</creatorcontrib><creatorcontrib>Ma, Zhifang</creatorcontrib><creatorcontrib>Xiang, Zehong</creatorcontrib><creatorcontrib>Xia, Yu</creatorcontrib><creatorcontrib>Shi, Qiang</creatorcontrib><creatorcontrib>Wong, Shing‐Chung</creatorcontrib><creatorcontrib>Yin, Jinghua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Macromolecular bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Runhai</au><au>Ma, Zhifang</au><au>Xiang, Zehong</au><au>Xia, Yu</au><au>Shi, Qiang</au><au>Wong, Shing‐Chung</au><au>Yin, Jinghua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrogen Peroxide and Glutathione Dual Redox‐Responsive Nanoparticles for Controlled DOX Release</atitle><jtitle>Macromolecular bioscience</jtitle><addtitle>Macromol Biosci</addtitle><date>2020-02</date><risdate>2020</risdate><volume>20</volume><issue>2</issue><spage>e1900331</spage><epage>n/a</epage><pages>e1900331-n/a</pages><issn>1616-5187</issn><eissn>1616-5195</eissn><abstract>Polymer nanoparticulate drug delivery systems that respond to reactive oxygen species (ROS) and glutathione (GSH) simultaneously at biologically relevant levels hold great promise to improve the therapeutic efficacy to cancer cells with reduced side effects of chemo drugs. Herein, a novel redox dual‐responsive amphiphilic block copolymer (ABP) that consists of a hydrophilic poly (ethylene oxide) block and a hydrophobic block bearing disulfide linked phenylboronic ester group as pendant is synthesized, and the DOX loaded nanoparticles (BSN‐DOX) based on ABPs with varied hydrophobic block length are fabricated for DOX delivery. The self‐immolative leaving reaction of phenylboronic ester triggered by extracellular ROS and the cleavage of disulfide linkages induced by intracellular GSH both lead to rapid DOX release from BSN‐DOX, resulting in an on‐demand DOX release. Moreover, BSN‐DOX show better tumor inhibition and lower side effects in vivo compared with free drug.
A novel redox dual‐responsive amphiphilic block copolymer that consists of a hydrophilic poly (ethylene oxide) block and a hydrophobic block bearing disulfide linked phenylboronic ester group as pendant is synthesized for DOX delivery. A controlled DOX release that is triggered sequentially by extracellular reactive oxygen species and intracellular glutathione of cancer cells, and the selective toxicity to tumor cells are obtained.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31856396</pmid><doi>10.1002/mabi.201900331</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4431-4434</orcidid></addata></record> |
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| subjects | Animals Block copolymers cancer Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics Delayed-Action Preparations - pharmacology Disulfide bonds DOX Doxorubicin - chemistry Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug Carriers - pharmacology Drug delivery Drug delivery systems dual‐responsive Ethylene oxide Female Glutathione Glutathione - metabolism HeLa Cells Humans Hydrogen peroxide Hydrogen Peroxide - metabolism Hydrophobicity Mice Nanoparticles Nanoparticles - chemistry Nanoparticles - therapeutic use Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Oxidation-Reduction Polymers Reactive oxygen species Side effects Xenograft Model Antitumor Assays |
| title | Hydrogen Peroxide and Glutathione Dual Redox‐Responsive Nanoparticles for Controlled DOX Release |
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