Encapsulin carrier proteins for enhanced expression of antimicrobial peptides

Antimicrobial peptides (AMPs) are regarded as attractive alternatives to conventional antibiotics, but their production in microbes remains challenging due to their inherent bactericidal nature. To address these limitations, we have developed a novel AMP fusion protein system based on an encapsulin...

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Veröffentlicht in:	Biotechnology and bioengineering 2020-03, Vol.117 (3), p.603-613
Hauptverfasser:	Lee, Tek‐Hyung, Carpenter, Timothy S., D'haeseleer, Patrik, Savage, David F., Yung, Mimi C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antiinfectives and antibacterials antimicrobial peptide Antimicrobial peptides Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism E coli Encapsulation encapsulin Endopeptidases - genetics Escherichia coli - drug effects Escherichia coli - genetics Fusion protein Gram-negative bacteria HBCM2 Minimum inhibitory concentration Models, Molecular nanocompartment Peptides Pore Forming Cytotoxic Proteins - chemistry Pore Forming Cytotoxic Proteins - genetics Pore Forming Cytotoxic Proteins - metabolism Pore Forming Cytotoxic Proteins - pharmacology Protease protein cage Proteinase Proteins Proteolysis Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Therapeutic applications toxic peptide production
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