Thimerosal-containing vaccines and deficit in child development: Population-based study in southern Brazil
The discussion on the safety of thimerosal-containing vaccines (TCVs) and their impact on child development it́s very relevant. Methods: This is a cohort study with mother-child dyads who received prenatal care in the Unified Health System. The domains of motor, cognitive and language development we...
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| Veröffentlicht in: | Vaccine 2020-02, Vol.38 (9), p.2216-2220 |
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| creator | da Cunha, Gabriela Kurz de Matos, Mariana Bonati Trettim, Jéssica Puchalski Rubin, Bárbara Borges de Avila Quevedo, Luciana Pinheiro, Karen Amaral Tavares da Cunha Coelho, Fabio Monteiro Pinheiro, Ricardo Tavares |
| description | The discussion on the safety of thimerosal-containing vaccines (TCVs) and their impact on child development it́s very relevant. Methods: This is a cohort study with mother-child dyads who received prenatal care in the Unified Health System. The domains of motor, cognitive and language development were evaluated in children between 24 and 36 months of age. Data on vaccination were obtained through the child's immunization record. A linear regression analysis was carried out considering possible confounders. Results: In bivariate analyses, motor and language development were associated with TCVs (p 0.05). These results indicate that the use of TCVs is not associated with child development. The importance of this study is summarized in transmitting relevant information regarding public health, based on reliable data. |
| doi_str_mv | 10.1016/j.vaccine.2019.12.044 |
| format | Article |
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Methods: This is a cohort study with mother-child dyads who received prenatal care in the Unified Health System. The domains of motor, cognitive and language development were evaluated in children between 24 and 36 months of age. Data on vaccination were obtained through the child's immunization record. A linear regression analysis was carried out considering possible confounders. Results: In bivariate analyses, motor and language development were associated with TCVs (p < 0.05). However, in the multivariate analysis, this association was not maintained (p > 0.05). These results indicate that the use of TCVs is not associated with child development. The importance of this study is summarized in transmitting relevant information regarding public health, based on reliable data.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2019.12.044</identifier><identifier>PMID: 32014269</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Age ; Anxiety ; Bivariate analysis ; Brazil ; Breastfeeding & lactation ; Child development ; Child Development - drug effects ; Child, Preschool ; Children & youth ; Cognitive ability ; Cognitive development ; Cohort Studies ; Hepatitis ; Humans ; Immunization ; Language ; Mothers ; Multivariate analysis ; Population studies ; Population-based studies ; Preservatives, Pharmaceutical - adverse effects ; Public health ; Regression analysis ; Statistical analysis ; Thimerosal ; Thimerosal - adverse effects ; Vaccination ; Vaccines ; Vaccines - adverse effects ; Variables</subject><ispartof>Vaccine, 2020-02, Vol.38 (9), p.2216-2220</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. 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Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-f8c60c2c3e3c80e9092693d45297777c79ec476483a5617dda752c718875ea0a3</citedby><cites>FETCH-LOGICAL-c393t-f8c60c2c3e3c80e9092693d45297777c79ec476483a5617dda752c718875ea0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2352601074?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32014269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Cunha, Gabriela Kurz</creatorcontrib><creatorcontrib>de Matos, Mariana Bonati</creatorcontrib><creatorcontrib>Trettim, Jéssica Puchalski</creatorcontrib><creatorcontrib>Rubin, Bárbara Borges</creatorcontrib><creatorcontrib>de Avila Quevedo, Luciana</creatorcontrib><creatorcontrib>Pinheiro, Karen Amaral Tavares</creatorcontrib><creatorcontrib>da Cunha Coelho, Fabio Monteiro</creatorcontrib><creatorcontrib>Pinheiro, Ricardo Tavares</creatorcontrib><title>Thimerosal-containing vaccines and deficit in child development: Population-based study in southern Brazil</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>The discussion on the safety of thimerosal-containing vaccines (TCVs) and their impact on child development it́s very relevant. 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The importance of this study is summarized in transmitting relevant information regarding public health, based on reliable data.</description><subject>Age</subject><subject>Anxiety</subject><subject>Bivariate analysis</subject><subject>Brazil</subject><subject>Breastfeeding & lactation</subject><subject>Child development</subject><subject>Child Development - drug effects</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Cognitive ability</subject><subject>Cognitive development</subject><subject>Cohort Studies</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Immunization</subject><subject>Language</subject><subject>Mothers</subject><subject>Multivariate analysis</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Preservatives, Pharmaceutical - adverse effects</subject><subject>Public health</subject><subject>Regression analysis</subject><subject>Statistical 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Brazil</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2020-02-24</date><risdate>2020</risdate><volume>38</volume><issue>9</issue><spage>2216</spage><epage>2220</epage><pages>2216-2220</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>The discussion on the safety of thimerosal-containing vaccines (TCVs) and their impact on child development it́s very relevant. Methods: This is a cohort study with mother-child dyads who received prenatal care in the Unified Health System. The domains of motor, cognitive and language development were evaluated in children between 24 and 36 months of age. Data on vaccination were obtained through the child's immunization record. A linear regression analysis was carried out considering possible confounders. Results: In bivariate analyses, motor and language development were associated with TCVs (p < 0.05). However, in the multivariate analysis, this association was not maintained (p > 0.05). These results indicate that the use of TCVs is not associated with child development. The importance of this study is summarized in transmitting relevant information regarding public health, based on reliable data.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>32014269</pmid><doi>10.1016/j.vaccine.2019.12.044</doi><tpages>5</tpages></addata></record> |
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| subjects | Age Anxiety Bivariate analysis Brazil Breastfeeding & lactation Child development Child Development - drug effects Child, Preschool Children & youth Cognitive ability Cognitive development Cohort Studies Hepatitis Humans Immunization Language Mothers Multivariate analysis Population studies Population-based studies Preservatives, Pharmaceutical - adverse effects Public health Regression analysis Statistical analysis Thimerosal Thimerosal - adverse effects Vaccination Vaccines Vaccines - adverse effects Variables |
| title | Thimerosal-containing vaccines and deficit in child development: Population-based study in southern Brazil |
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