Gold nano particles synthesized from Strychni semen and its anticancer activity in cholangiocarcinoma cell (KMCH-1)
Nanotechnology has been materialized as a proficient technology for the development of anticancer nanoparticles all the way through an environment-friendly approach. Conventionally, nanoparticles have been assembled by dissimilar methods, but regrettably rely on the negative impact on the natural en...
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| Veröffentlicht in: | Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2019-12, Vol.47 (1), p.1610-1616 |
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| container_title | Artificial cells, nanomedicine, and biotechnology |
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| creator | Li, Yuehua Ke, Yang Zou, Hao Wang, Kun Huang, Songquan Rengarajan, Thamaraiselvan Wang, Lin |
| description | Nanotechnology has been materialized as a proficient technology for the development of anticancer nanoparticles all the way through an environment-friendly approach. Conventionally, nanoparticles have been assembled by dissimilar methods, but regrettably rely on the negative impact on the natural environment. Amalgamation of nanoparticles by means of plant extract is alternate conservative methods. In the present study, we equipped gold nanoparticles (AuNPs) from Strychni semen; displayed as a less toxic and environment-friendly. Integration of AuNPs was famed by UV-absorbance which displays peak values. Moreover, high-resolution transmission electron microscopy (HR-TEM), energy dispersive X-ray analysis (EDX) and atomic force microscopy (AFM) substantiate the shape of the AuNPs in the combined materials. FTIR results exhibit the active molecules positioned in the flat surface of the AuNPs. Similarly, the anticancer effectiveness of AuNPs is considered in KMCH-1 cells. Also, AuNPs successfully aggravate cytotoxicity and apoptosis by conjugating apoptotic gene expressions in KMCH-1 cells. Eventually, our results confirm the synthesis of AuNPs from Strychni Semen shows anticancer effects with environment-friendly manner. |
| doi_str_mv | 10.1080/21691401.2019.1594860 |
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Conventionally, nanoparticles have been assembled by dissimilar methods, but regrettably rely on the negative impact on the natural environment. Amalgamation of nanoparticles by means of plant extract is alternate conservative methods. In the present study, we equipped gold nanoparticles (AuNPs) from Strychni semen; displayed as a less toxic and environment-friendly. Integration of AuNPs was famed by UV-absorbance which displays peak values. Moreover, high-resolution transmission electron microscopy (HR-TEM), energy dispersive X-ray analysis (EDX) and atomic force microscopy (AFM) substantiate the shape of the AuNPs in the combined materials. FTIR results exhibit the active molecules positioned in the flat surface of the AuNPs. Similarly, the anticancer effectiveness of AuNPs is considered in KMCH-1 cells. Also, AuNPs successfully aggravate cytotoxicity and apoptosis by conjugating apoptotic gene expressions in KMCH-1 cells. Eventually, our results confirm the synthesis of AuNPs from Strychni Semen shows anticancer effects with environment-friendly manner.</description><identifier>ISSN: 2169-1401</identifier><identifier>EISSN: 2169-141X</identifier><identifier>DOI: 10.1080/21691401.2019.1594860</identifier><identifier>PMID: 31072209</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Anticancer properties ; Antitumor activity ; Apoptosis ; Atomic force microscopy ; AuNPs ; Cancer ; Cholangiocarcinoma ; cholangiocarcinoma cell ; Cytotoxicity ; Environmental impact ; Flat surfaces ; Gold ; KMCH-1 cells ; Microscopy ; Nanoparticles ; Nanotechnology ; Plant extracts ; Semen ; Strychni Semen ; Toxicity ; Transmission electron microscopy ; X ray analysis</subject><ispartof>Artificial cells, nanomedicine, and biotechnology, 2019-12, Vol.47 (1), p.1610-1616</ispartof><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2019</rights><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Conventionally, nanoparticles have been assembled by dissimilar methods, but regrettably rely on the negative impact on the natural environment. Amalgamation of nanoparticles by means of plant extract is alternate conservative methods. In the present study, we equipped gold nanoparticles (AuNPs) from Strychni semen; displayed as a less toxic and environment-friendly. Integration of AuNPs was famed by UV-absorbance which displays peak values. Moreover, high-resolution transmission electron microscopy (HR-TEM), energy dispersive X-ray analysis (EDX) and atomic force microscopy (AFM) substantiate the shape of the AuNPs in the combined materials. FTIR results exhibit the active molecules positioned in the flat surface of the AuNPs. Similarly, the anticancer effectiveness of AuNPs is considered in KMCH-1 cells. Also, AuNPs successfully aggravate cytotoxicity and apoptosis by conjugating apoptotic gene expressions in KMCH-1 cells. Eventually, our results confirm the synthesis of AuNPs from Strychni Semen shows anticancer effects with environment-friendly manner.</description><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Apoptosis</subject><subject>Atomic force microscopy</subject><subject>AuNPs</subject><subject>Cancer</subject><subject>Cholangiocarcinoma</subject><subject>cholangiocarcinoma cell</subject><subject>Cytotoxicity</subject><subject>Environmental impact</subject><subject>Flat surfaces</subject><subject>Gold</subject><subject>KMCH-1 cells</subject><subject>Microscopy</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Plant extracts</subject><subject>Semen</subject><subject>Strychni Semen</subject><subject>Toxicity</subject><subject>Transmission electron microscopy</subject><subject>X ray analysis</subject><issn>2169-1401</issn><issn>2169-141X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>DOA</sourceid><recordid>eNp9UctuFDEQHCEQiUI-AWSJSzjs4vZjxr6BIggRQRwAiZvl8SPr1Yy92LOg4evxsJs9cMCXttpV1V2upnkOeA1Y4NcEWgkMw5pgkGvgkokWP2rOl_4KGHx_fLpjOGsuS9niegS0HWdPmzMKuCMEy_Om3KTBoqhjQjudp2AGV1CZ47RxJfx2FvmcRvRlyrPZxICKG11EOloUplJrJehoXEbaTOFnmGYUIjKbNOh4H5LR2YSYRo2MGwZ09fHT9YcVvHrWPPF6KO7yWC-ab-_ffa1Pd59vbq_f3q0Mx9208s47aqSmgjMKFHNrMKHea0EwIR6AMEmEph4MIeC8FEz31PgWekaZofSiuT3o2qS3apfDqPOskg7qbyPle3W0rHrrhXHQ995ixlnfS8w51ta3HJzgfdW6Omjtcvqxd2VSYyiLKx1d2hdFCAVZf5h0FfryH-g27XOsThWhnFAhabcsxw8ok1Mp2fnTgoDVErJ6CFktIatjyJX34qi-70dnT6yHSCvgzQEQok951L9SHqya9Dyk7HNNK5QF_L8ZfwALM7U-</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Li, Yuehua</creator><creator>Ke, Yang</creator><creator>Zou, Hao</creator><creator>Wang, Kun</creator><creator>Huang, Songquan</creator><creator>Rengarajan, Thamaraiselvan</creator><creator>Wang, Lin</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>201912</creationdate><title>Gold nano particles synthesized from Strychni semen and its anticancer activity in cholangiocarcinoma cell (KMCH-1)</title><author>Li, Yuehua ; Ke, Yang ; Zou, Hao ; Wang, Kun ; Huang, Songquan ; Rengarajan, Thamaraiselvan ; Wang, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-fefe3c9a385431305dc023ffa82022f1124928a3f1c221ef984ab3cf61b434c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anticancer properties</topic><topic>Antitumor activity</topic><topic>Apoptosis</topic><topic>Atomic force microscopy</topic><topic>AuNPs</topic><topic>Cancer</topic><topic>Cholangiocarcinoma</topic><topic>cholangiocarcinoma cell</topic><topic>Cytotoxicity</topic><topic>Environmental impact</topic><topic>Flat surfaces</topic><topic>Gold</topic><topic>KMCH-1 cells</topic><topic>Microscopy</topic><topic>Nanoparticles</topic><topic>Nanotechnology</topic><topic>Plant extracts</topic><topic>Semen</topic><topic>Strychni Semen</topic><topic>Toxicity</topic><topic>Transmission electron microscopy</topic><topic>X ray analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yuehua</creatorcontrib><creatorcontrib>Ke, Yang</creatorcontrib><creatorcontrib>Zou, Hao</creatorcontrib><creatorcontrib>Wang, Kun</creatorcontrib><creatorcontrib>Huang, Songquan</creatorcontrib><creatorcontrib>Rengarajan, Thamaraiselvan</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yuehua</au><au>Ke, Yang</au><au>Zou, Hao</au><au>Wang, Kun</au><au>Huang, Songquan</au><au>Rengarajan, Thamaraiselvan</au><au>Wang, Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gold nano particles synthesized from Strychni semen and its anticancer activity in cholangiocarcinoma cell (KMCH-1)</atitle><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle><addtitle>Artif Cells Nanomed Biotechnol</addtitle><date>2019-12</date><risdate>2019</risdate><volume>47</volume><issue>1</issue><spage>1610</spage><epage>1616</epage><pages>1610-1616</pages><issn>2169-1401</issn><eissn>2169-141X</eissn><abstract>Nanotechnology has been materialized as a proficient technology for the development of anticancer nanoparticles all the way through an environment-friendly approach. Conventionally, nanoparticles have been assembled by dissimilar methods, but regrettably rely on the negative impact on the natural environment. Amalgamation of nanoparticles by means of plant extract is alternate conservative methods. In the present study, we equipped gold nanoparticles (AuNPs) from Strychni semen; displayed as a less toxic and environment-friendly. Integration of AuNPs was famed by UV-absorbance which displays peak values. Moreover, high-resolution transmission electron microscopy (HR-TEM), energy dispersive X-ray analysis (EDX) and atomic force microscopy (AFM) substantiate the shape of the AuNPs in the combined materials. FTIR results exhibit the active molecules positioned in the flat surface of the AuNPs. Similarly, the anticancer effectiveness of AuNPs is considered in KMCH-1 cells. Also, AuNPs successfully aggravate cytotoxicity and apoptosis by conjugating apoptotic gene expressions in KMCH-1 cells. 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| subjects | Anticancer properties Antitumor activity Apoptosis Atomic force microscopy AuNPs Cancer Cholangiocarcinoma cholangiocarcinoma cell Cytotoxicity Environmental impact Flat surfaces Gold KMCH-1 cells Microscopy Nanoparticles Nanotechnology Plant extracts Semen Strychni Semen Toxicity Transmission electron microscopy X ray analysis |
| title | Gold nano particles synthesized from Strychni semen and its anticancer activity in cholangiocarcinoma cell (KMCH-1) |
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