The protective role of microRNA-133b in restricting hippocampal neurons apoptosis and inflammatory injury in rats with depression by suppressing CTGF

Objective Increasing evidence has proved the functions of microRNAs (miRNAs) in human diseases, our research was designed to explore the effects of miR-133b on the progression of depression with the involvement of connective tissue growth factor (CTGF). Methods Depression rat models were established...

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Veröffentlicht in:	International immunopharmacology 2020-01, Vol.78, p.1
Hauptverfasser:	Pei, Gaoyou, Xu, Liguo, Huang, Wenhao, Yin, Jianjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Apoptosis BAX protein Bcl-2 protein Brain-derived neurotrophic factor Connective tissue growth factor Connective tissues Ethology Glial fibrillary acidic protein Growth factors Hippocampus IL-1β Inflammation Injuries Interleukin 6 MicroRNAs miRNA Neuronal-glial interactions Neurons Neurotransmitters Ribonucleic acid RNA Tissues Tumor necrosis factor-TNF Tumor necrosis factor-α
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