Crystal engineering as a scientific basis for modification of physicochemical properties of bioflavonoids
Flavonoids are of interest for pharmacy and medicinal chemistry due to a wide range of biological activities. The major goal for the design of new drugs based on flavonoids is to increase bioavailability of pharmaceutical substances. Crystal engineering is a useful tool for this purpose. This review...
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| Veröffentlicht in: | Russian chemical bulletin 2019-12, Vol.68 (12), p.2155-2162 |
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| container_title | Russian chemical bulletin |
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| creator | Selivanova, I. A. Terekhov, R. P. |
| description | Flavonoids are of interest for pharmacy and medicinal chemistry due to a wide range of biological activities. The major goal for the design of new drugs based on flavonoids is to increase bioavailability of pharmaceutical substances. Crystal engineering is a useful tool for this purpose. This review presents a systematic analysis of the publications on crystal engineering of flavonoids published between 2000 and 2019. The data on objects, methods of supramolecular synthesis, analysis, and preclinical studies of its products are summarized. The trends in crystal engineering of flavonoids are considered and promising areas for further research are identified. The review may be of interest for researchers engaged in the design of drugs with low bioavailability, including bioflavonoids. |
| doi_str_mv | 10.1007/s11172-019-2684-z |
| format | Article |
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A.</creatorcontrib><creatorcontrib>Terekhov, R. P.</creatorcontrib><title>Crystal engineering as a scientific basis for modification of physicochemical properties of bioflavonoids</title><title>Russian chemical bulletin</title><addtitle>Russ Chem Bull</addtitle><description>Flavonoids are of interest for pharmacy and medicinal chemistry due to a wide range of biological activities. The major goal for the design of new drugs based on flavonoids is to increase bioavailability of pharmaceutical substances. Crystal engineering is a useful tool for this purpose. This review presents a systematic analysis of the publications on crystal engineering of flavonoids published between 2000 and 2019. The data on objects, methods of supramolecular synthesis, analysis, and preclinical studies of its products are summarized. The trends in crystal engineering of flavonoids are considered and promising areas for further research are identified. The review may be of interest for researchers engaged in the design of drugs with low bioavailability, including bioflavonoids.</description><subject>Bioavailability</subject><subject>Bioflavonoids</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Crystals</subject><subject>Drugs</subject><subject>Engineering</subject><subject>Flavonoids</subject><subject>Inorganic Chemistry</subject><subject>Organic Chemistry</subject><subject>Reviews</subject><issn>1066-5285</issn><issn>1573-9171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKAzEUhoMoWKsP4C7gOppLc5mlFG9QcKPrkMmlTWknYzIV2qc3wwiuXJ3r_5_DB8AtwfcEY_lQCCGSIkwaRIVaoNMZmBEuGWqIJOc1x0IgThW_BFelbDHGVCk1A3GZj2UwO-i7dey8z7FbQ1OggcVG3w0xRAtbU2KBIWW4T27smCGmDqYA-82xRJvsxu9rdwf7nHqfh-jLOG1jCjvznboUXbkGF8Hsir_5jXPw-fz0sXxFq_eXt-XjCllGxIACoW3jrGpVoEKYhjeuZV7UygW8kM2ixUoqzpljznLhWLAtZpx54xSTXrE5uJt86y9fB18GvU2H3NWTmjJOOG-YpHWLTFs2p1KyD7rPcW_yUROsR6J6IqorUT0S1aeqoZOm9CMmn_-c_xf9AEsLe84</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Selivanova, I. 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P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-f12b9dc8b8f266a959db3e68f2df04794b0878553d3dc56d3fcb0353ead837e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bioavailability</topic><topic>Bioflavonoids</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Crystals</topic><topic>Drugs</topic><topic>Engineering</topic><topic>Flavonoids</topic><topic>Inorganic Chemistry</topic><topic>Organic Chemistry</topic><topic>Reviews</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Selivanova, I. A.</creatorcontrib><creatorcontrib>Terekhov, R. 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| subjects | Bioavailability Bioflavonoids Chemistry Chemistry and Materials Science Chemistry/Food Science Crystals Drugs Engineering Flavonoids Inorganic Chemistry Organic Chemistry Reviews |
| title | Crystal engineering as a scientific basis for modification of physicochemical properties of bioflavonoids |
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