Upregulation of PPAR-gamma activity inhibits cyclooxygenase 2 expression in cortical neurons with N-methyl-d-aspartic acid induced excitatory neurotoxicity

This study aimed to investigate the effect of upregulated peroxisome proliferator-activated receptor-gamma (PPAR-γ) activity on cyclooxygenase 2 (COX-2) expression and N-methyl-d-aspartic acid (NMDA)-induced excitatory neurotoxicity in primary cultured cortical neurons. Rat cortical neurons were cul...

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Veröffentlicht in:	Biotechnology, biotechnological equipment biotechnological equipment, 2019-01, Vol.33 (1), p.1018-1023
Hauptverfasser:	Weng, Qi-Fang, Chen, Guo-Bin, Xu, Min-Guang, Long, Ru-Tao, Wang, Han, Wang, Xiao-Ying, Jiang, Chao-Na, Yi, Xi-Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspartic acid ca2+ concentrations Calcium (intracellular) Calcium ions Cell viability Cholecystokinin concentrations COX-2 Cyclooxygenase-2 Dizocilpine excitatory neurotoxicity Flow cytometry Glutamic acid receptors Glutamic acid receptors (ionotropic) N-Methyl-D-aspartic acid receptors Neurons Neurotoxicity NMDA Peroxisome proliferator-activated receptors PPAR-γ Protein expression Proteins Rosiglitazone Up-regulation
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