Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate
The aim of drug delivery is to increase therapeutic efficacy. Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of an anticancer agent from sonosensitive liposomes (SL). To re...
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| Veröffentlicht in: | Drug delivery 2019-01, Vol.26 (1), p.724-731 |
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| creator | Lin, Wen Ma, Xiaoxing Zhou, Chaopei Yang, Hong Yang, Yang Xie, Xiangyang Yang, Chunrong Han, Cuiyan |
| description | The aim of drug delivery is to increase therapeutic efficacy. Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of an anticancer agent from sonosensitive liposomes (SL). To realize the ultrasound-triggered drug release, a lipophilic sonosensitizer, hematoporphyrin monomethyl ether (HMME) was incorporated into the lipid bilayer of liposomes. Once irradiated by the ultrasound in tumor tissues, the sonodynamic effect generated by HMME could lead to an efficient disruption of the lipid bilayer in the SL. After encapsulating vincristine bitartrate (VIN) as the model drug, the ultrasound-triggered lipid bilayer breakdown can trigger the instant release of VIN, enabling ultrasound-controlled chemotherapy with great specificity. In the in vitro and in vivo studies, by integrating tumor-specific targeting and stimuli-responsive controlled release into one system, VIN-loaded SL showed excellent antitumor efficacy. The SL could potentially produce viable clinical strategies for improved targeting efficiency of VIN for the treatment of related cancer. More importantly, this report provides an example of controlled release by means of a novel class of ultrasound triggering system. |
| doi_str_mv | 10.1080/10717544.2019.1639845 |
| format | Article |
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Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of an anticancer agent from sonosensitive liposomes (SL). To realize the ultrasound-triggered drug release, a lipophilic sonosensitizer, hematoporphyrin monomethyl ether (HMME) was incorporated into the lipid bilayer of liposomes. Once irradiated by the ultrasound in tumor tissues, the sonodynamic effect generated by HMME could lead to an efficient disruption of the lipid bilayer in the SL. After encapsulating vincristine bitartrate (VIN) as the model drug, the ultrasound-triggered lipid bilayer breakdown can trigger the instant release of VIN, enabling ultrasound-controlled chemotherapy with great specificity. In the in vitro and in vivo studies, by integrating tumor-specific targeting and stimuli-responsive controlled release into one system, VIN-loaded SL showed excellent antitumor efficacy. The SL could potentially produce viable clinical strategies for improved targeting efficiency of VIN for the treatment of related cancer. More importantly, this report provides an example of controlled release by means of a novel class of ultrasound triggering system.</description><identifier>ISSN: 1071-7544</identifier><identifier>EISSN: 1521-0464</identifier><identifier>DOI: 10.1080/10717544.2019.1639845</identifier><identifier>PMID: 31293182</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; Antineoplastic Agents, Phytogenic - administration & dosage ; Antineoplastic Agents, Phytogenic - pharmacokinetics ; Cancer therapies ; Chemotherapy ; control release ; drug delivery system ; Drug Delivery Systems ; Drug Liberation ; Drugs ; Female ; Hematoporphyrins - administration & dosage ; Humans ; Laboratory animals ; Light ; Lipids ; Liposomes - administration & dosage ; Liposomes - chemistry ; MCF-7 Cells ; Mice ; Mice, Inbred BALB C ; Pharmacy ; Phase transitions ; Physiology ; Rats ; Rats, Sprague-Dawley ; sonodynamic effect ; sonosensitizer ; Tumors ; Ultrasonic imaging ; Ultrasonography ; Ultrasound sensitivity ; Vincristine - administration & dosage ; Vincristine - pharmacokinetics ; Vincristine - pharmacology ; Xenograft Model Antitumor Assays</subject><ispartof>Drug delivery, 2019-01, Vol.26 (1), p.724-731</ispartof><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2019</rights><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2019 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-4e01821e90a7c149f0663d8e39e12c2db1db3ce4cb2b256e786d262d08d677f23</citedby><cites>FETCH-LOGICAL-c562t-4e01821e90a7c149f0663d8e39e12c2db1db3ce4cb2b256e786d262d08d677f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691763/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691763/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31293182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Wen</creatorcontrib><creatorcontrib>Ma, Xiaoxing</creatorcontrib><creatorcontrib>Zhou, Chaopei</creatorcontrib><creatorcontrib>Yang, Hong</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Xie, Xiangyang</creatorcontrib><creatorcontrib>Yang, Chunrong</creatorcontrib><creatorcontrib>Han, Cuiyan</creatorcontrib><title>Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate</title><title>Drug delivery</title><addtitle>Drug Deliv</addtitle><description>The aim of drug delivery is to increase therapeutic efficacy. Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of an anticancer agent from sonosensitive liposomes (SL). To realize the ultrasound-triggered drug release, a lipophilic sonosensitizer, hematoporphyrin monomethyl ether (HMME) was incorporated into the lipid bilayer of liposomes. Once irradiated by the ultrasound in tumor tissues, the sonodynamic effect generated by HMME could lead to an efficient disruption of the lipid bilayer in the SL. After encapsulating vincristine bitartrate (VIN) as the model drug, the ultrasound-triggered lipid bilayer breakdown can trigger the instant release of VIN, enabling ultrasound-controlled chemotherapy with great specificity. In the in vitro and in vivo studies, by integrating tumor-specific targeting and stimuli-responsive controlled release into one system, VIN-loaded SL showed excellent antitumor efficacy. The SL could potentially produce viable clinical strategies for improved targeting efficiency of VIN for the treatment of related cancer. More importantly, this report provides an example of controlled release by means of a novel class of ultrasound triggering system.</description><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - administration & dosage</subject><subject>Antineoplastic Agents, Phytogenic - pharmacokinetics</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>control release</subject><subject>drug delivery system</subject><subject>Drug Delivery Systems</subject><subject>Drug Liberation</subject><subject>Drugs</subject><subject>Female</subject><subject>Hematoporphyrins - administration & dosage</subject><subject>Humans</subject><subject>Laboratory animals</subject><subject>Light</subject><subject>Lipids</subject><subject>Liposomes - administration & dosage</subject><subject>Liposomes - chemistry</subject><subject>MCF-7 Cells</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Pharmacy</subject><subject>Phase transitions</subject><subject>Physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>sonodynamic effect</subject><subject>sonosensitizer</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Ultrasound sensitivity</subject><subject>Vincristine - administration & dosage</subject><subject>Vincristine - pharmacokinetics</subject><subject>Vincristine - pharmacology</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1071-7544</issn><issn>1521-0464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp9kctuFDEQRVsIRB7wCSBLrHvw2-4NAgUCkSKxgRULy21XJx5124PtGZS_x5OZRGTDypbr1K3rul33huAVwRq_J1gRJThfUUyGFZFs0Fw8606JoKTHXPLn7d6Yfg-ddGelrDHGmlDxsjthhA6MaHra_foMO5jTZoFYkY0euVubrauQQ6nBFZQmFFNDUEkxFYgl1LADNIdNKmmBgqaU0S5Ed98QAY2h2lyzrfCqezHZucDr43ne_bz88uPiW3_9_evVxafr3glJa88BNysEBmyVI3yYsJTMa2ADEOqoH4kfmQPuRjpSIUFp6amkHmsvlZooO--uDro-2bXZ5LDYfGeSDeb-IeUb0xwFN4PBig0SsFOWaD4wq2FSwDQIgZ1gXDWtDwetzXZcwLu2lmznJ6JPKzHcmpu0M1IOREnWBN4dBXL6vYVSzTptc2z_N5QJgpluy2-UOFAup1IyTI8TCDb7fM1Dvmafrznm2_re_mvvsesh0AZ8PAAhtmAW-yfl2Ztq7-aUp2yjC6XB_53xFyxFtlU</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Lin, Wen</creator><creator>Ma, Xiaoxing</creator><creator>Zhou, Chaopei</creator><creator>Yang, Hong</creator><creator>Yang, Yang</creator><creator>Xie, Xiangyang</creator><creator>Yang, Chunrong</creator><creator>Han, Cuiyan</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20190101</creationdate><title>Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate</title><author>Lin, Wen ; 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Externally triggered drug delivery systems enable site-specific and time-controlled drug release. To achieve this goal, our strategy was based on ultrasound-triggered release of an anticancer agent from sonosensitive liposomes (SL). To realize the ultrasound-triggered drug release, a lipophilic sonosensitizer, hematoporphyrin monomethyl ether (HMME) was incorporated into the lipid bilayer of liposomes. Once irradiated by the ultrasound in tumor tissues, the sonodynamic effect generated by HMME could lead to an efficient disruption of the lipid bilayer in the SL. After encapsulating vincristine bitartrate (VIN) as the model drug, the ultrasound-triggered lipid bilayer breakdown can trigger the instant release of VIN, enabling ultrasound-controlled chemotherapy with great specificity. In the in vitro and in vivo studies, by integrating tumor-specific targeting and stimuli-responsive controlled release into one system, VIN-loaded SL showed excellent antitumor efficacy. The SL could potentially produce viable clinical strategies for improved targeting efficiency of VIN for the treatment of related cancer. More importantly, this report provides an example of controlled release by means of a novel class of ultrasound triggering system.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>31293182</pmid><doi>10.1080/10717544.2019.1639845</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacokinetics Cancer therapies Chemotherapy control release drug delivery system Drug Delivery Systems Drug Liberation Drugs Female Hematoporphyrins - administration & dosage Humans Laboratory animals Light Lipids Liposomes - administration & dosage Liposomes - chemistry MCF-7 Cells Mice Mice, Inbred BALB C Pharmacy Phase transitions Physiology Rats Rats, Sprague-Dawley sonodynamic effect sonosensitizer Tumors Ultrasonic imaging Ultrasonography Ultrasound sensitivity Vincristine - administration & dosage Vincristine - pharmacokinetics Vincristine - pharmacology Xenograft Model Antitumor Assays |
| title | Development and characteristics of novel sonosensitive liposomes for vincristine bitartrate |
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