Synthesis and characterization of one impurity in esomeprazole, an antiulcerative drug
During drug synthesis, control of impurities is very important to get high-qualified drugs. A number of studies have devoted to synthesize the impurities and study the structures to support the method of purification. In this paper, we first synthesize one impurity in esomeprazole, rel-2-[[(3,5-dime...
Gespeichert in:
| Veröffentlicht in: | Chemical papers 2020-03, Vol.74 (3), p.867-877 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 877 |
|---|---|
| container_issue | 3 |
| container_start_page | 867 |
| container_title | Chemical papers |
| container_volume | 74 |
| creator | Liu, Zhen-Tao Meng, Xia Fang, Shi-Min Wang, Li-Zhen Wang, Zhen-Zheng Yang, Geng Duan, Hong-Dong Hao, Ai-You |
| description | During drug synthesis, control of impurities is very important to get high-qualified drugs. A number of studies have devoted to synthesize the impurities and study the structures to support the method of purification. In this paper, we first synthesize one impurity in esomeprazole, rel-2-[[(3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-6-methoxy-1
H
-benzimidazole, with readily available raw materials, simple operation procedures and relatively mild reaction. Besides, we characterized its structure by MS, IR,
1
H-NMR and HPLC analyses. The purity of target compound is as high as 99.58%, which can be used as the reference substance of the impurities of esomeprazole. |
| doi_str_mv | 10.1007/s11696-019-00918-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2350937168</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2350937168</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-e7225b0af3d1b7e5dae087dda17b5f210845abb2afe824836d1e1389e6234113</originalsourceid><addsrcrecordid>eNp9kEtLAzEUhYMoWGr_gKuAW6N5TB6zlOILCi4sbkNm5k4baSdjMiO0v97oCO6EC2dzvnPhQ-iS0RtGqb5NjKlSEcpKQmnJDBEnaMaEUKSkWp6iGZdGEs1Leo4WKfmKFoUW3Cg9Q2-vh27YQvIJu67B9dZFVw8Q_dENPnQ4tDh0gP2-H6MfDth3GFLYQx_dMezgOlP5Bj_uaogZ-QTcxHFzgc5at0uw-M05Wj_cr5dPZPXy-Ly8W5FaSDUQ0JzLirpWNKzSIBsH1OimcUxXsuWMmkK6quKuBcMLI1TDgAlTguKiYEzM0dU028fwMUIa7HsYY5c_Wi4kLYVmyuQWn1p1DClFaG0f_d7Fg2XUfhu0k0GbDdofg1ZkSExQyuVuA_Fv-h_qCzFwdKc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2350937168</pqid></control><display><type>article</type><title>Synthesis and characterization of one impurity in esomeprazole, an antiulcerative drug</title><source>SpringerNature Journals</source><creator>Liu, Zhen-Tao ; Meng, Xia ; Fang, Shi-Min ; Wang, Li-Zhen ; Wang, Zhen-Zheng ; Yang, Geng ; Duan, Hong-Dong ; Hao, Ai-You</creator><creatorcontrib>Liu, Zhen-Tao ; Meng, Xia ; Fang, Shi-Min ; Wang, Li-Zhen ; Wang, Zhen-Zheng ; Yang, Geng ; Duan, Hong-Dong ; Hao, Ai-You</creatorcontrib><description>During drug synthesis, control of impurities is very important to get high-qualified drugs. A number of studies have devoted to synthesize the impurities and study the structures to support the method of purification. In this paper, we first synthesize one impurity in esomeprazole, rel-2-[[(3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-6-methoxy-1
H
-benzimidazole, with readily available raw materials, simple operation procedures and relatively mild reaction. Besides, we characterized its structure by MS, IR,
1
H-NMR and HPLC analyses. The purity of target compound is as high as 99.58%, which can be used as the reference substance of the impurities of esomeprazole.</description><identifier>ISSN: 2585-7290</identifier><identifier>ISSN: 0366-6352</identifier><identifier>EISSN: 1336-9075</identifier><identifier>DOI: 10.1007/s11696-019-00918-3</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Biochemistry ; Biotechnology ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Impurities ; Industrial Chemistry/Chemical Engineering ; Materials Science ; Medicinal Chemistry ; NMR ; Nuclear magnetic resonance ; Original Paper ; Raw materials ; Synthesis</subject><ispartof>Chemical papers, 2020-03, Vol.74 (3), p.867-877</ispartof><rights>Institute of Chemistry, Slovak Academy of Sciences 2019</rights><rights>2019© Institute of Chemistry, Slovak Academy of Sciences 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-e7225b0af3d1b7e5dae087dda17b5f210845abb2afe824836d1e1389e6234113</citedby><cites>FETCH-LOGICAL-c356t-e7225b0af3d1b7e5dae087dda17b5f210845abb2afe824836d1e1389e6234113</cites><orcidid>0000-0002-0731-6732</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11696-019-00918-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11696-019-00918-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Liu, Zhen-Tao</creatorcontrib><creatorcontrib>Meng, Xia</creatorcontrib><creatorcontrib>Fang, Shi-Min</creatorcontrib><creatorcontrib>Wang, Li-Zhen</creatorcontrib><creatorcontrib>Wang, Zhen-Zheng</creatorcontrib><creatorcontrib>Yang, Geng</creatorcontrib><creatorcontrib>Duan, Hong-Dong</creatorcontrib><creatorcontrib>Hao, Ai-You</creatorcontrib><title>Synthesis and characterization of one impurity in esomeprazole, an antiulcerative drug</title><title>Chemical papers</title><addtitle>Chem. Pap</addtitle><description>During drug synthesis, control of impurities is very important to get high-qualified drugs. A number of studies have devoted to synthesize the impurities and study the structures to support the method of purification. In this paper, we first synthesize one impurity in esomeprazole, rel-2-[[(3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-6-methoxy-1
H
-benzimidazole, with readily available raw materials, simple operation procedures and relatively mild reaction. Besides, we characterized its structure by MS, IR,
1
H-NMR and HPLC analyses. The purity of target compound is as high as 99.58%, which can be used as the reference substance of the impurities of esomeprazole.</description><subject>Biochemistry</subject><subject>Biotechnology</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Impurities</subject><subject>Industrial Chemistry/Chemical Engineering</subject><subject>Materials Science</subject><subject>Medicinal Chemistry</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Original Paper</subject><subject>Raw materials</subject><subject>Synthesis</subject><issn>2585-7290</issn><issn>0366-6352</issn><issn>1336-9075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLAzEUhYMoWGr_gKuAW6N5TB6zlOILCi4sbkNm5k4baSdjMiO0v97oCO6EC2dzvnPhQ-iS0RtGqb5NjKlSEcpKQmnJDBEnaMaEUKSkWp6iGZdGEs1Leo4WKfmKFoUW3Cg9Q2-vh27YQvIJu67B9dZFVw8Q_dENPnQ4tDh0gP2-H6MfDth3GFLYQx_dMezgOlP5Bj_uaogZ-QTcxHFzgc5at0uw-M05Wj_cr5dPZPXy-Ly8W5FaSDUQ0JzLirpWNKzSIBsH1OimcUxXsuWMmkK6quKuBcMLI1TDgAlTguKiYEzM0dU028fwMUIa7HsYY5c_Wi4kLYVmyuQWn1p1DClFaG0f_d7Fg2XUfhu0k0GbDdofg1ZkSExQyuVuA_Fv-h_qCzFwdKc</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Liu, Zhen-Tao</creator><creator>Meng, Xia</creator><creator>Fang, Shi-Min</creator><creator>Wang, Li-Zhen</creator><creator>Wang, Zhen-Zheng</creator><creator>Yang, Geng</creator><creator>Duan, Hong-Dong</creator><creator>Hao, Ai-You</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-0731-6732</orcidid></search><sort><creationdate>20200301</creationdate><title>Synthesis and characterization of one impurity in esomeprazole, an antiulcerative drug</title><author>Liu, Zhen-Tao ; Meng, Xia ; Fang, Shi-Min ; Wang, Li-Zhen ; Wang, Zhen-Zheng ; Yang, Geng ; Duan, Hong-Dong ; Hao, Ai-You</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-e7225b0af3d1b7e5dae087dda17b5f210845abb2afe824836d1e1389e6234113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biochemistry</topic><topic>Biotechnology</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Impurities</topic><topic>Industrial Chemistry/Chemical Engineering</topic><topic>Materials Science</topic><topic>Medicinal Chemistry</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Original Paper</topic><topic>Raw materials</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Zhen-Tao</creatorcontrib><creatorcontrib>Meng, Xia</creatorcontrib><creatorcontrib>Fang, Shi-Min</creatorcontrib><creatorcontrib>Wang, Li-Zhen</creatorcontrib><creatorcontrib>Wang, Zhen-Zheng</creatorcontrib><creatorcontrib>Yang, Geng</creatorcontrib><creatorcontrib>Duan, Hong-Dong</creatorcontrib><creatorcontrib>Hao, Ai-You</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical papers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Zhen-Tao</au><au>Meng, Xia</au><au>Fang, Shi-Min</au><au>Wang, Li-Zhen</au><au>Wang, Zhen-Zheng</au><au>Yang, Geng</au><au>Duan, Hong-Dong</au><au>Hao, Ai-You</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and characterization of one impurity in esomeprazole, an antiulcerative drug</atitle><jtitle>Chemical papers</jtitle><stitle>Chem. Pap</stitle><date>2020-03-01</date><risdate>2020</risdate><volume>74</volume><issue>3</issue><spage>867</spage><epage>877</epage><pages>867-877</pages><issn>2585-7290</issn><issn>0366-6352</issn><eissn>1336-9075</eissn><abstract>During drug synthesis, control of impurities is very important to get high-qualified drugs. A number of studies have devoted to synthesize the impurities and study the structures to support the method of purification. In this paper, we first synthesize one impurity in esomeprazole, rel-2-[[(3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-6-methoxy-1
H
-benzimidazole, with readily available raw materials, simple operation procedures and relatively mild reaction. Besides, we characterized its structure by MS, IR,
1
H-NMR and HPLC analyses. The purity of target compound is as high as 99.58%, which can be used as the reference substance of the impurities of esomeprazole.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s11696-019-00918-3</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0731-6732</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2585-7290 |
| ispartof | Chemical papers, 2020-03, Vol.74 (3), p.867-877 |
| issn | 2585-7290 0366-6352 1336-9075 |
| language | eng |
| recordid | cdi_proquest_journals_2350937168 |
| source | SpringerNature Journals |
| subjects | Biochemistry Biotechnology Chemistry Chemistry and Materials Science Chemistry/Food Science Impurities Industrial Chemistry/Chemical Engineering Materials Science Medicinal Chemistry NMR Nuclear magnetic resonance Original Paper Raw materials Synthesis |
| title | Synthesis and characterization of one impurity in esomeprazole, an antiulcerative drug |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T04%3A01%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20and%20characterization%20of%20one%20impurity%20in%20esomeprazole,%20an%20antiulcerative%20drug&rft.jtitle=Chemical%20papers&rft.au=Liu,%20Zhen-Tao&rft.date=2020-03-01&rft.volume=74&rft.issue=3&rft.spage=867&rft.epage=877&rft.pages=867-877&rft.issn=2585-7290&rft.eissn=1336-9075&rft_id=info:doi/10.1007/s11696-019-00918-3&rft_dat=%3Cproquest_cross%3E2350937168%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2350937168&rft_id=info:pmid/&rfr_iscdi=true |