Chordate PIAS proteins act as conserved repressors of the TRAF6 self-polyubiquitination

In mammals, PIAS proteins are important SUMO E3 ligases and act as versatile regulators of over sixty different proteins, including components from the NF-κB pathways. But the PIAS functions are not well-understood due to complicated molecular mechanisms and multiple gene paralogs with overlapping r...

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Veröffentlicht in:	Developmental and comparative immunology 2020-03, Vol.104, p.103554, Article 103554
Hauptverfasser:	Fu, Xianan, Wang, Ruihua, Li, Mingshi, Yan, Xinyu, Huang, Huiqing, Li, Jin, Chen, Shenghui, Yue, Zirui, Chen, Shangwu, Li, Yingqiu, Dong, Meiling, Xu, Anlong, Huang, Shengfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Amphioxus Cephalochordata Immunoregulation Mammalian cells Mammals Molecular modelling Mutants NF-κB protein PIAS Proteins Regulators Repressors SUMO protein TRAF6 TRAF6 protein Ubiquitin Ubiquitin-protein ligase Ubiquitination Vertebrates
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