Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles

Despite the fact that small-sized lipid nanoparticles (LNPs) are important for improved tissue penetration and efficient drug delivery, their poor stability and intracellular trafficking significantly hinders their use as potent small-sized LNPs. It has been reported that both the diffusion of lipid...

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Veröffentlicht in:Acta biomaterialia 2020-01, Vol.102, p.341-350
Hauptverfasser: Sato, Yusuke, Okabe, Nana, Note, Yusuke, Hashiba, Kazuki, Maeki, Masatoshi, Tokeshi, Manabu, Harashima, Hideyoshi
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Sprache:eng
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