Quantum dot conjugated saporin activates microglia and induces selective substantia nigra degeneration

•Quantum dots (QDs) were selectively taken up by microglia and activated these cells.•QDs alone had minimal effect son neurons and astrocytes.•Saporin conjugated QDs (QD-SAP) were toxic to nigral dopaminergic neurons.•QD-SAP caused marked behavioral impairment.•QD-SAP increased nigral levels of the...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2020-01, Vol.76, p.153-161
Hauptverfasser:	Landrigan, Jeffrey, Dwyer, Zach, Beauchamp, Sheryl, Rodriguez, Ruth, Fortin, Teresa, Hayley, Shawn
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animals Contaminants Degeneration Dopamine Dopaminergic Neurons - drug effects Dopaminergic Neurons - pathology Drug Carriers - toxicity Encephalitis - chemically induced Encephalitis - metabolism Fluorescence Inflammation Mice, Inbred C57BL Microglia Microglia - drug effects Microglia - pathology Movement disorders Neurodegenerative diseases Neurons Parkinson's disease Pars Compacta - drug effects Pars Compacta - pathology Quantum dot Quantum dots Quantum Dots - toxicity Saporin Saporins - toxicity Substantia nigra Toxicant Toxicants Toxicology - methods Toxins
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