Transition-metal-free synthesis of CMe2CF3-containing chroman-4-ones via decarboxylative trifluoroalkylation

(NH4)2S2O8-mediated decarboxylative trifluoroalkylation of alkenes with 3,3,3-trifluoro-2,2-dimethylpropanoic acid under metal-free conditions has been described. This approach provides a new pathway to directly synthesize a series of CMe2CF3-containing chroman-4-ones from simple chemical feedstocks...

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Veröffentlicht in:	Organic chemistry frontiers an international journal of organic chemistry 2020-02, Vol.7 (3), p.487-491
Hauptverfasser:	Miao-Chang, Liu, Liu, Wei, Hua-Yue, Wu, Yun-Bing, Zhou, Ding, Qiuping, Peng, Yiyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes Capsaicin receptors Crystallography Organic chemistry Transition metals
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creator	Miao-Chang, Liu Liu, Wei Hua-Yue, Wu Yun-Bing, Zhou Ding, Qiuping Peng, Yiyuan
description	(NH4)2S2O8-mediated decarboxylative trifluoroalkylation of alkenes with 3,3,3-trifluoro-2,2-dimethylpropanoic acid under metal-free conditions has been described. This approach provides a new pathway to directly synthesize a series of CMe2CF3-containing chroman-4-ones from simple chemical feedstocks. Particularly, the utility of the method was demonstrated by its application in the synthesis of CMe2CF3-derived TRPV1 precursors.
doi_str_mv	10.1039/c9qo01283d
format	Article
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subjects	Alkenes Capsaicin receptors Crystallography Organic chemistry Transition metals
title	Transition-metal-free synthesis of CMe2CF3-containing chroman-4-ones via decarboxylative trifluoroalkylation
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