Transdermal delivery of rapamycin with poor water-solubility by dissolving polymeric microneedles for anti-angiogenesis

Angiogenesis plays an important role in the occurrence and development of skin tumors and vascular anomalies (VAs). Many drugs have been adopted for the inhibition of angiogenesis, among which rapamycin (RAPA) possesses good application prospects. However, the clinical potential of RAPA for VAs is l...

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Veröffentlicht in:	Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2020-02, Vol.8 (5), p.928-934
Hauptverfasser:	Mao, Jinzhu, Wang, Hua, Xie, Ying, Fu, Yangxue, Li, Yuce, Liu, Pei, Du, Hongyao, Zhu, Jinjin, Dong, Liyun, Hussain, Mubashir, Li, Yan, Zhang, Lianbin, Zhu, Jintao, Tao, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Angiogenesis Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Anomalies Antiangiogenics Bioavailability Cell Proliferation - drug effects Cells, Cultured Cytotoxicity Drug delivery Drug Delivery Systems Drug development Endothelial cells Excavation Growth factors Humans Materials Testing Mechanical properties Needles Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Particle Size Polymers - administration & dosage Polymers - chemistry Polymers - pharmacology Polyvinylpyrrolidone Rapamycin Sirolimus - administration & dosage Sirolimus - chemistry Sirolimus - pharmacology Skin Solubility Stratum corneum Surface Properties Toxicity Transdermal medication Tumors Umbilical vein Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism Vascular Malformations - drug therapy Vascular Malformations - metabolism Vascular Malformations - pathology Water - chemistry
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