A case of diffuse midline glioma, H3 K27M mutant mimicking a hemispheric malignant glioma in an elderly patient
Diffuse midline glioma, H3 K27M mutant arises from midline structures of the central nervous system and predominately affects pediatric patients. However, this disease entity was only recently established, and the clinical phenotypic spectrum remains largely unclear. We herein report a rare case of...
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| Veröffentlicht in: | Neuropathology 2020-02, Vol.40 (1), p.99-103 |
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| container_title | Neuropathology |
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| creator | Fujioka, Yutaka Hata, Nobuhiro Hatae, Ryusuke Suzuki, Satoshi O. Sangatsuda, Yuhei Nakahara, Yukiko Mizoguchi, Masahiro Iihara, Koji |
| description | Diffuse midline glioma, H3 K27M mutant arises from midline structures of the central nervous system and predominately affects pediatric patients. However, this disease entity was only recently established, and the clinical phenotypic spectrum remains largely unclear. We herein report a rare case of diffuse midline glioma, H3 K27M mutant with an unusual distribution in an elderly woman who presented with a diffuse glioma that invaded both sides of the thalami, and left hippocampus and frontoparietal lobes, thus mimicking a hemispheric malignant glioma. A biopsy of the lobular lesion led to a molecular diagnostic confirmation of diffuse midline glioma, H3 K27M mutant. The patient received concurrent bevacizumab and temozolomide therapy with radiation therapy and survived for 30 months. This case highlights the possibility that a glioma with cerebral hemispheric spread in an elderly patient may harbor the H3 K27M mutation. |
| doi_str_mv | 10.1111/neup.12609 |
| format | Article |
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However, this disease entity was only recently established, and the clinical phenotypic spectrum remains largely unclear. We herein report a rare case of diffuse midline glioma, H3 K27M mutant with an unusual distribution in an elderly woman who presented with a diffuse glioma that invaded both sides of the thalami, and left hippocampus and frontoparietal lobes, thus mimicking a hemispheric malignant glioma. A biopsy of the lobular lesion led to a molecular diagnostic confirmation of diffuse midline glioma, H3 K27M mutant. The patient received concurrent bevacizumab and temozolomide therapy with radiation therapy and survived for 30 months. This case highlights the possibility that a glioma with cerebral hemispheric spread in an elderly patient may harbor the H3 K27M mutation.</description><identifier>ISSN: 0919-6544</identifier><identifier>EISSN: 1440-1789</identifier><identifier>DOI: 10.1111/neup.12609</identifier><identifier>PMID: 31762138</identifier><language>eng</language><publisher>Melbourne: John Wiley & Sons Australia, Ltd</publisher><subject>aged patient ; Bevacizumab ; Biopsy ; brain ; Central nervous system ; diffuse midline glioma H3 K27M mutant ; Geriatrics ; Glioma ; Mimicry ; Monoclonal antibodies ; Mutants ; Older people ; Patients ; Pediatrics ; Radiation therapy ; Temozolomide</subject><ispartof>Neuropathology, 2020-02, Vol.40 (1), p.99-103</ispartof><rights>2019 Japanese Society of Neuropathology</rights><rights>2019 Japanese Society of Neuropathology.</rights><rights>2020 Japanese Society of Neuropathology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4149-58edb555591637763d1e83f3c4dba8ef33c537de77568f79d9dfc707dffc1a263</citedby><cites>FETCH-LOGICAL-c4149-58edb555591637763d1e83f3c4dba8ef33c537de77568f79d9dfc707dffc1a263</cites><orcidid>0000-0002-5523-7166</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fneup.12609$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fneup.12609$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31762138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujioka, Yutaka</creatorcontrib><creatorcontrib>Hata, Nobuhiro</creatorcontrib><creatorcontrib>Hatae, Ryusuke</creatorcontrib><creatorcontrib>Suzuki, Satoshi O.</creatorcontrib><creatorcontrib>Sangatsuda, Yuhei</creatorcontrib><creatorcontrib>Nakahara, Yukiko</creatorcontrib><creatorcontrib>Mizoguchi, Masahiro</creatorcontrib><creatorcontrib>Iihara, Koji</creatorcontrib><title>A case of diffuse midline glioma, H3 K27M mutant mimicking a hemispheric malignant glioma in an elderly patient</title><title>Neuropathology</title><addtitle>Neuropathology</addtitle><description>Diffuse midline glioma, H3 K27M mutant arises from midline structures of the central nervous system and predominately affects pediatric patients. However, this disease entity was only recently established, and the clinical phenotypic spectrum remains largely unclear. We herein report a rare case of diffuse midline glioma, H3 K27M mutant with an unusual distribution in an elderly woman who presented with a diffuse glioma that invaded both sides of the thalami, and left hippocampus and frontoparietal lobes, thus mimicking a hemispheric malignant glioma. A biopsy of the lobular lesion led to a molecular diagnostic confirmation of diffuse midline glioma, H3 K27M mutant. The patient received concurrent bevacizumab and temozolomide therapy with radiation therapy and survived for 30 months. This case highlights the possibility that a glioma with cerebral hemispheric spread in an elderly patient may harbor the H3 K27M mutation.</description><subject>aged patient</subject><subject>Bevacizumab</subject><subject>Biopsy</subject><subject>brain</subject><subject>Central nervous system</subject><subject>diffuse midline glioma H3 K27M mutant</subject><subject>Geriatrics</subject><subject>Glioma</subject><subject>Mimicry</subject><subject>Monoclonal antibodies</subject><subject>Mutants</subject><subject>Older people</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Radiation therapy</subject><subject>Temozolomide</subject><issn>0919-6544</issn><issn>1440-1789</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EoqWw4QOQJXaIgCdO4nhZVeUhymMB68i1x61L4oQ8hPr3pARYMpsZac7ckQ4hp8CuoK9rj111BWHC5B4ZQxSxAEQq98mYSZBBEkfRiBw1zYYxEDJMD8mIg0hC4OmYlFOqVYO0tNQ4a7t-LJzJnUe6yl1ZqEt6x-lDKB5p0bXKt_26cPrd-RVVdI2Fa6o11k7TQuVu5XfEcEidp8pTzA3W-ZZWqnXo22NyYFXe4MlPn5C3m_nr7C5YPN_ez6aLQEcQySBO0SzjviQkXIiEG8CUW64js1QpWs51zIVBIeIktUIaaawWTBhrNagw4RNyPuRWdfnRYdNmm7Krff8yC3nMgDNIw566GChdl01To82q2hWq3mbAsp3bbOc2-3bbw2c_kd2yQPOH_srsARiAT5fj9p-o7Gn-9jKEfgEXgoPT</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Fujioka, Yutaka</creator><creator>Hata, Nobuhiro</creator><creator>Hatae, Ryusuke</creator><creator>Suzuki, Satoshi O.</creator><creator>Sangatsuda, Yuhei</creator><creator>Nakahara, Yukiko</creator><creator>Mizoguchi, Masahiro</creator><creator>Iihara, Koji</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-5523-7166</orcidid></search><sort><creationdate>202002</creationdate><title>A case of diffuse midline glioma, H3 K27M mutant mimicking a hemispheric malignant glioma in an elderly patient</title><author>Fujioka, Yutaka ; Hata, Nobuhiro ; Hatae, Ryusuke ; Suzuki, Satoshi O. ; Sangatsuda, Yuhei ; Nakahara, Yukiko ; Mizoguchi, Masahiro ; Iihara, Koji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4149-58edb555591637763d1e83f3c4dba8ef33c537de77568f79d9dfc707dffc1a263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>aged patient</topic><topic>Bevacizumab</topic><topic>Biopsy</topic><topic>brain</topic><topic>Central nervous system</topic><topic>diffuse midline glioma H3 K27M mutant</topic><topic>Geriatrics</topic><topic>Glioma</topic><topic>Mimicry</topic><topic>Monoclonal antibodies</topic><topic>Mutants</topic><topic>Older people</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Radiation therapy</topic><topic>Temozolomide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujioka, Yutaka</creatorcontrib><creatorcontrib>Hata, Nobuhiro</creatorcontrib><creatorcontrib>Hatae, Ryusuke</creatorcontrib><creatorcontrib>Suzuki, Satoshi O.</creatorcontrib><creatorcontrib>Sangatsuda, Yuhei</creatorcontrib><creatorcontrib>Nakahara, Yukiko</creatorcontrib><creatorcontrib>Mizoguchi, Masahiro</creatorcontrib><creatorcontrib>Iihara, Koji</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Neuropathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujioka, Yutaka</au><au>Hata, Nobuhiro</au><au>Hatae, Ryusuke</au><au>Suzuki, Satoshi O.</au><au>Sangatsuda, Yuhei</au><au>Nakahara, Yukiko</au><au>Mizoguchi, Masahiro</au><au>Iihara, Koji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of diffuse midline glioma, H3 K27M mutant mimicking a hemispheric malignant glioma in an elderly patient</atitle><jtitle>Neuropathology</jtitle><addtitle>Neuropathology</addtitle><date>2020-02</date><risdate>2020</risdate><volume>40</volume><issue>1</issue><spage>99</spage><epage>103</epage><pages>99-103</pages><issn>0919-6544</issn><eissn>1440-1789</eissn><abstract>Diffuse midline glioma, H3 K27M mutant arises from midline structures of the central nervous system and predominately affects pediatric patients. However, this disease entity was only recently established, and the clinical phenotypic spectrum remains largely unclear. We herein report a rare case of diffuse midline glioma, H3 K27M mutant with an unusual distribution in an elderly woman who presented with a diffuse glioma that invaded both sides of the thalami, and left hippocampus and frontoparietal lobes, thus mimicking a hemispheric malignant glioma. A biopsy of the lobular lesion led to a molecular diagnostic confirmation of diffuse midline glioma, H3 K27M mutant. The patient received concurrent bevacizumab and temozolomide therapy with radiation therapy and survived for 30 months. This case highlights the possibility that a glioma with cerebral hemispheric spread in an elderly patient may harbor the H3 K27M mutation.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>31762138</pmid><doi>10.1111/neup.12609</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-5523-7166</orcidid></addata></record> |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | aged patient Bevacizumab Biopsy brain Central nervous system diffuse midline glioma H3 K27M mutant Geriatrics Glioma Mimicry Monoclonal antibodies Mutants Older people Patients Pediatrics Radiation therapy Temozolomide |
| title | A case of diffuse midline glioma, H3 K27M mutant mimicking a hemispheric malignant glioma in an elderly patient |
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