The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease
Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been invest...
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| Veröffentlicht in: | International Heart Journal 2020/01/31, Vol.61(1), pp.115-120 |
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| creator | Huang, Maozhi Zheng, Jianping Chen, Ziguo You, Chaoqun Huang, Qilei |
| description | Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we aimed to investigate relationship between circulating neuregulin-1 levels and CCC in stable coronary artery disease patients.Coronary artery disease patients with a stenosis of ≥ 90% as evidenced by coronary angiography were included in our study. According to the Rentrop-Cohen classification, coronary collateral degree was graded as 1 to 4. Patients with collateral degree grade 0 or 1 were enrolled in poor CCC group, whereas patients with grade 2 or 3 were enrolled in good CCC group.Plasma neuregulin-1 level was significantly increased in good collateral group and positively related to Rentrop grade (P < 0.01). Multivariate regression analysis and ROC (receiver operating characteristic curve) revealed that plasma neuregulin-1 could predict CCC status effectively.Increased plasma neuregulin-1 level was related to better CCC in patients with coronary artery disease. Neuregulin-1 was an independent and reliable predictor for good coronary collateral development and provided a potential therapeutic strategy to reduce myocardial ischemia injury. |
| doi_str_mv | 10.1536/ihj.19-277 |
| format | Article |
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Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we aimed to investigate relationship between circulating neuregulin-1 levels and CCC in stable coronary artery disease patients.Coronary artery disease patients with a stenosis of ≥ 90% as evidenced by coronary angiography were included in our study. According to the Rentrop-Cohen classification, coronary collateral degree was graded as 1 to 4. Patients with collateral degree grade 0 or 1 were enrolled in poor CCC group, whereas patients with grade 2 or 3 were enrolled in good CCC group.Plasma neuregulin-1 level was significantly increased in good collateral group and positively related to Rentrop grade (P < 0.01). Multivariate regression analysis and ROC (receiver operating characteristic curve) revealed that plasma neuregulin-1 could predict CCC status effectively.Increased plasma neuregulin-1 level was related to better CCC in patients with coronary artery disease. Neuregulin-1 was an independent and reliable predictor for good coronary collateral development and provided a potential therapeutic strategy to reduce myocardial ischemia injury.</description><identifier>ISSN: 1349-2365</identifier><identifier>EISSN: 1349-3299</identifier><identifier>DOI: 10.1536/ihj.19-277</identifier><identifier>PMID: 31956140</identifier><language>eng</language><publisher>Japan: International Heart Journal Association</publisher><subject>Aged ; Angiogenesis ; Angiography ; Biomarker ; Biomarkers - blood ; Cardiomyopathy ; Cardiovascular disease ; Collateral Circulation ; Coronary Angiography ; Coronary artery ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - metabolism ; Coronary Circulation ; Coronary vessels ; Diabetes mellitus ; Electrocardiography ; Female ; Heart diseases ; Humans ; Ischemia ; Male ; Middle Aged ; Multivariate Analysis ; Myocardial ischemia ; Myocardium ; Neuregulin ; Neuregulin 1 ; Neuregulin-1 - blood ; ROC Curve ; Stenosis ; Up-Regulation</subject><ispartof>International Heart Journal, 2020/01/31, Vol.61(1), pp.115-120</ispartof><rights>2020 by the International Heart Journal Association</rights><rights>Copyright Japan Science and Technology Agency 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-2f6364c534076ef70bced35997f3410587f1ec489692a3d78ff0b32110857ab63</citedby><cites>FETCH-LOGICAL-c498t-2f6364c534076ef70bced35997f3410587f1ec489692a3d78ff0b32110857ab63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31956140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Maozhi</creatorcontrib><creatorcontrib>Zheng, Jianping</creatorcontrib><creatorcontrib>Chen, Ziguo</creatorcontrib><creatorcontrib>You, Chaoqun</creatorcontrib><creatorcontrib>Huang, Qilei</creatorcontrib><title>The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease</title><title>International Heart Journal</title><addtitle>Int. Heart J.</addtitle><description>Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we aimed to investigate relationship between circulating neuregulin-1 levels and CCC in stable coronary artery disease patients.Coronary artery disease patients with a stenosis of ≥ 90% as evidenced by coronary angiography were included in our study. According to the Rentrop-Cohen classification, coronary collateral degree was graded as 1 to 4. Patients with collateral degree grade 0 or 1 were enrolled in poor CCC group, whereas patients with grade 2 or 3 were enrolled in good CCC group.Plasma neuregulin-1 level was significantly increased in good collateral group and positively related to Rentrop grade (P < 0.01). Multivariate regression analysis and ROC (receiver operating characteristic curve) revealed that plasma neuregulin-1 could predict CCC status effectively.Increased plasma neuregulin-1 level was related to better CCC in patients with coronary artery disease. Neuregulin-1 was an independent and reliable predictor for good coronary collateral development and provided a potential therapeutic strategy to reduce myocardial ischemia injury.</description><subject>Aged</subject><subject>Angiogenesis</subject><subject>Angiography</subject><subject>Biomarker</subject><subject>Biomarkers - blood</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular disease</subject><subject>Collateral Circulation</subject><subject>Coronary Angiography</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - metabolism</subject><subject>Coronary Circulation</subject><subject>Coronary vessels</subject><subject>Diabetes mellitus</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Myocardial ischemia</subject><subject>Myocardium</subject><subject>Neuregulin</subject><subject>Neuregulin 1</subject><subject>Neuregulin-1 - blood</subject><subject>ROC Curve</subject><subject>Stenosis</subject><subject>Up-Regulation</subject><issn>1349-2365</issn><issn>1349-3299</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPAyEYRYnR-Khu_AGGxJ3JKK-BYafWZ9KoMbomdPpNh2ZkKsykceNvF9taN3AD57uQg9AxJec05_LC1bNzqjOm1Bbap1zojDOtt9eZcZnvoYMYZ4QImhO1i_Y41bmkguyj77ca8Cs0tnOtj7Wb42voFgAeD10o-99zP8VP0AeY9o3zGcXWT_CwDa234SuFJjEQbPM_0HrsPH5JCXwX8cJ19f_AVUj0F75xEWyEQ7RT2SbC0XofoPe727fhQzZ6vn8cXo2yUuiiy1gluRRlzgVREipFxiVMeK61qrigJC9URaEUhZaaWT5RRVWRMWeUkiJXdiz5AJ2ueueh_ewhdmbW9sGnJw1LkgrFBGOJOltRZWhjDFCZeXAf6deGEvOr2iTVhmqTVCf4ZF3Zjz9gskH_3CbgcgXMYmensAFs6FzZwLJLUkOXy7Jzc1XWNhjw_Aced5F7</recordid><startdate>20200131</startdate><enddate>20200131</enddate><creator>Huang, Maozhi</creator><creator>Zheng, Jianping</creator><creator>Chen, Ziguo</creator><creator>You, Chaoqun</creator><creator>Huang, Qilei</creator><general>International Heart Journal Association</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope></search><sort><creationdate>20200131</creationdate><title>The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease</title><author>Huang, Maozhi ; Zheng, Jianping ; Chen, Ziguo ; You, Chaoqun ; Huang, Qilei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-2f6364c534076ef70bced35997f3410587f1ec489692a3d78ff0b32110857ab63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Angiogenesis</topic><topic>Angiography</topic><topic>Biomarker</topic><topic>Biomarkers - blood</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular disease</topic><topic>Collateral Circulation</topic><topic>Coronary Angiography</topic><topic>Coronary artery</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - metabolism</topic><topic>Coronary Circulation</topic><topic>Coronary vessels</topic><topic>Diabetes mellitus</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Myocardial ischemia</topic><topic>Myocardium</topic><topic>Neuregulin</topic><topic>Neuregulin 1</topic><topic>Neuregulin-1 - blood</topic><topic>ROC Curve</topic><topic>Stenosis</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Maozhi</creatorcontrib><creatorcontrib>Zheng, Jianping</creatorcontrib><creatorcontrib>Chen, Ziguo</creatorcontrib><creatorcontrib>You, Chaoqun</creatorcontrib><creatorcontrib>Huang, Qilei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>International Heart Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Maozhi</au><au>Zheng, Jianping</au><au>Chen, Ziguo</au><au>You, Chaoqun</au><au>Huang, Qilei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease</atitle><jtitle>International Heart Journal</jtitle><addtitle>Int. Heart J.</addtitle><date>2020-01-31</date><risdate>2020</risdate><volume>61</volume><issue>1</issue><spage>115</spage><epage>120</epage><pages>115-120</pages><issn>1349-2365</issn><eissn>1349-3299</eissn><abstract>Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we aimed to investigate relationship between circulating neuregulin-1 levels and CCC in stable coronary artery disease patients.Coronary artery disease patients with a stenosis of ≥ 90% as evidenced by coronary angiography were included in our study. According to the Rentrop-Cohen classification, coronary collateral degree was graded as 1 to 4. Patients with collateral degree grade 0 or 1 were enrolled in poor CCC group, whereas patients with grade 2 or 3 were enrolled in good CCC group.Plasma neuregulin-1 level was significantly increased in good collateral group and positively related to Rentrop grade (P < 0.01). Multivariate regression analysis and ROC (receiver operating characteristic curve) revealed that plasma neuregulin-1 could predict CCC status effectively.Increased plasma neuregulin-1 level was related to better CCC in patients with coronary artery disease. Neuregulin-1 was an independent and reliable predictor for good coronary collateral development and provided a potential therapeutic strategy to reduce myocardial ischemia injury.</abstract><cop>Japan</cop><pub>International Heart Journal Association</pub><pmid>31956140</pmid><doi>10.1536/ihj.19-277</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Angiogenesis Angiography Biomarker Biomarkers - blood Cardiomyopathy Cardiovascular disease Collateral Circulation Coronary Angiography Coronary artery Coronary Artery Disease - blood Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - metabolism Coronary Circulation Coronary vessels Diabetes mellitus Electrocardiography Female Heart diseases Humans Ischemia Male Middle Aged Multivariate Analysis Myocardial ischemia Myocardium Neuregulin Neuregulin 1 Neuregulin-1 - blood ROC Curve Stenosis Up-Regulation |
| title | The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease |
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