Effects of arsenic exposure on d-serine metabolism in the hippocampus of offspring mice at different developmental stages

The main purpose of this study was to verify the hypothesis that cognitive dysfunctions induced by arsenic exposure were related to the changes of d -serine metabolism in the hippocampus of offspring mice. Mother mice and their offsprings were exposed to 0, 15, 30 or 60 mg/L sodium arsenite (NaAsO 2...

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Veröffentlicht in:	Archives of toxicology 2020, Vol.94 (1), p.77-87
Hauptverfasser:	Wang, Yan, Yang, Xiaoxia, Yu, Haiyang, Wang, Huan, Qi, Yingying, Geng, Mengyao
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amino acid oxidase Amino Acid Transport System y+ - genetics Amino Acid Transport System y+ - metabolism Amino acids Animals Arsenic Arsenic - toxicity Arsenite Biomedical and Life Sciences Biomedicine Body Weight - drug effects Cognitive ability D-Amino-acid oxidase D-Amino-Acid Oxidase - genetics D-Amino-Acid Oxidase - metabolism D-Serine Developmental stages Drinking water Environmental Health Exposure Female Gene expression Gestation Glutamic acid receptors High performance liquid chromatography Hippocampus Hippocampus - drug effects Hippocampus - growth & development Hippocampus - metabolism Inorganic Compounds Lactation Learning - drug effects Liquid chromatography Male Memory - drug effects Metabolism Mice Morris Water Maze Test mRNA N-Methyl-D-aspartic acid receptors Occupational Medicine/Industrial Medicine Offspring Organ Size - drug effects Pharmacology/Toxicology Polymerase chain reaction Pregnancy Prenatal Exposure Delayed Effects - chemically induced Protein expression Proteins Racemases and Epimerases - genetics Racemases and Epimerases - metabolism Receptors Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Serine - metabolism Serine racemase Sodium arsenite
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