MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/β-catenin signaling pathway

Glioma stem cells (GSCs) decrease T cells cognition and evade systemic immunosurveillance via downregulations or defects of major histocompatibility complex class I (MHC-I) molecule and antigen-processing machinery (APM) components. Improvement of tumor surface antigens of GSCs may be effective stra...

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Veröffentlicht in:	Oncogene 2020-01, Vol.39 (5), p.1098-1111
Hauptverfasser:	Yang, Wei, Li, Yanyan, Gao, Ruoling, Xiu, Zenghe, Sun, Ting
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/31 14 38 631/250/251 631/67/580/1884 631/67/71 Adaptive immunity Animals Antigen (tumor-associated) Antigen Presentation - immunology Antigen processing Antigens Apoptosis Brain tumors Carcinogenesis Cell activation Cell Biology Cell Line, Tumor Cognition Cytotoxicity Gene Knockdown Techniques Glioma Glioma - immunology Glioma - metabolism Glioma - pathology Glioma cells Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism Histone deacetylase Human Genetics Humans Immunosurveillance Immunotherapy Internal Medicine Kinases Lymphocytes Lymphocytes T Major histocompatibility complex Medicine Medicine & Public Health Mice Neoplastic Stem Cells - immunology Neoplastic Stem Cells - pathology Oncology Proto-Oncogene Proteins c-myc - metabolism Signal transduction Stem cells Surface antigens T-Lymphocytes, Cytotoxic - immunology Wnt protein Wnt Signaling Pathway - immunology β-Catenin
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