cGMP favors the interaction between APP and BACE1 by inhibiting Rab5 GTPase activity

We previously demonstrated that cyclic guanosine monophosphate (cGMP) stimulates amyloid precursor protein (APP) and beta-secretase (BACE1) approximation in neuronal endo-lysosomal compartments, thus boosting the production of amyloid-β (Aβ) peptides and enhancing synaptic plasticity and memory. Her...

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Veröffentlicht in:	Scientific reports 2020-01, Vol.10 (1), p.1358-1358, Article 1358
Hauptverfasser:	Caudano, Francesca, Montalto, Giulia, Passalacqua, Mario, Pronzato, Maria A., Fedele, Ernesto, Ricciarelli, Roberta
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 14/19 38/70 631/378/340 631/378/87 82/80 96 96/35 Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Amyloid precursor protein Amyloid Precursor Protein Secretases - genetics Amyloid Precursor Protein Secretases - metabolism Animals Approximation Aspartic Acid Endopeptidases - genetics Aspartic Acid Endopeptidases - metabolism Cell Line Cell Membrane - genetics Cell Membrane - metabolism Cell Membrane - pathology Cyclic GMP Endosomes Endosomes - genetics Endosomes - metabolism Endosomes - pathology Extracellular levels GTP-binding protein Guanosine Guanosine triphosphatases Humanities and Social Sciences Localization Mice Mimicry multidisciplinary Multidisciplinary Sciences Mutants Neurodegenerative diseases Peptides Plasmids Proteins rab5 GTP-Binding Proteins - genetics rab5 GTP-Binding Proteins - metabolism Rab5 protein Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Second Messenger Systems Secretase Synaptic plasticity β-Site APP-cleaving enzyme 1
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