Co-occurring genetic alterations and primary EGFR T790M mutations detected by NGS in pre-TKI-treated NSCLCs

Introduction Next-generation sequencing (NGS)-based assays to understand various mutations and co-occurrence of genomic alterations in non-small cell lung cancer (NSCLC) have enabled understanding of treatment impact on clinical outcomes. Methods This retrospective study was conducted in 1353 formal...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2020-02, Vol.146 (2), p.407-416
Hauptverfasser:	Tang, Yuan, Che, Nanying, Yu, Yang, Gao, Yun, Shi, Huaiyin, Feng, Qin, Wei, Bing, Ma, Liheng, Gao, Min, Ma, Jie, Lin, Dongmei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Cancer Research Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - genetics Colon Colon cancer Deoxyribonucleic acid DNA DNA sequencing DNA, Neoplasm - genetics Epidermal growth factor receptors ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics Female Hematology High-Throughput Nucleotide Sequencing Humans Internal Medicine Life Sciences & Biomedicine Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Lung Neoplasms - genetics Male Medical research Medicine Medicine & Public Health Middle Aged Mutation Next-generation sequencing Non-small cell lung carcinoma Oncology Original Article – Clinical Oncology p53 Protein Paraffin Patients Protein Kinase Inhibitors - administration & dosage Retrospective Studies Ribonucleic acid RNA RNA, Neoplasm - genetics Science & Technology Small cell lung carcinoma Young Adult
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