Fabrication of folate functionalized polyoxometalate nanoparticle to simultaneously detect H2O2 and sarcosine in colorimetry

[Display omitted] •FA-PMo4V8 is used in colorimetric assay of H2O2 with detection limit as 0.012 μM.•FA-PMo4V8 catalyzes sarcosine in O2 to generate H2O2 without sarcosine oxidase.•FA-PMo4V8 showed high selectivity and detection limit of 0.311 μM for sarcosine.•Sarcosine in urine is detected with re...

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Veröffentlicht in:Sensors and actuators. B, Chemical Chemical, 2020-02, Vol.304, p.127429, Article 127429
Hauptverfasser: Mbage, Bawa, Li, Yiming, Si, Haipei, Zhang, Xueyan, Li, Yue, Wang, Xiaohong, Salah, Abdulwahab, Zhang, Kaizhi
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container_start_page 127429
container_title Sensors and actuators. B, Chemical
container_volume 304
creator Mbage, Bawa
Li, Yiming
Si, Haipei
Zhang, Xueyan
Li, Yue
Wang, Xiaohong
Salah, Abdulwahab
Zhang, Kaizhi
description [Display omitted] •FA-PMo4V8 is used in colorimetric assay of H2O2 with detection limit as 0.012 μM.•FA-PMo4V8 catalyzes sarcosine in O2 to generate H2O2 without sarcosine oxidase.•FA-PMo4V8 showed high selectivity and detection limit of 0.311 μM for sarcosine.•Sarcosine in urine is detected with recoveries range 97.8–104.3 % with CV < 7 %.•Sarcosine is detected in prostate cancer urine by FA-PMo4V8. The colorimetric detection of sarcosine, a possible biomarker of prostate cancer (PCa), is long-standing research interest and challenge. Folate functionalized polyoxometalate (FA-PMo4V8) was designed and found to detect H2O2 and sarcosine without using peroxidase and sarcosine oxidase (SOD) in 3,3,5,5-tetramethylbezidine (TMB) colorimetric reaction. At optimal condition, FA-PMo4V8 exhibited excellent peroxidase-like activity and catalyzed the oxidation of TMB during detection of H2O2 concentrations in the linear range of 0.007 to 4 μM at limit of detection of 0.012 μM. Also, FA-PMo4V8 was found to mimic SOD by reacting with sarcosine in the presence of oxygen to generate H2O2, glycine and formaldehyde. Sarcosine concentrations were indirectly detected by FA-PMo4V8 with the linear range of 0.2–500 μM at limit of detection of 0.311 μM. FA-PMo4V8 was easily fabricated and exhibited good selectivity, reproducible and sensitivity for detecting H2O2 and sarcosine in broader pH range. FA-PMo4V8 further discriminated PCa patients and healthy persons based on urinary sarcosine concentrations. This study demonstrated that FA-PMo4V8 is simply designed and accurate in colorimetric detection of urinary sarcosine, which could be useful for clinical applications.
doi_str_mv 10.1016/j.snb.2019.127429
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The colorimetric detection of sarcosine, a possible biomarker of prostate cancer (PCa), is long-standing research interest and challenge. Folate functionalized polyoxometalate (FA-PMo4V8) was designed and found to detect H2O2 and sarcosine without using peroxidase and sarcosine oxidase (SOD) in 3,3,5,5-tetramethylbezidine (TMB) colorimetric reaction. At optimal condition, FA-PMo4V8 exhibited excellent peroxidase-like activity and catalyzed the oxidation of TMB during detection of H2O2 concentrations in the linear range of 0.007 to 4 μM at limit of detection of 0.012 μM. Also, FA-PMo4V8 was found to mimic SOD by reacting with sarcosine in the presence of oxygen to generate H2O2, glycine and formaldehyde. Sarcosine concentrations were indirectly detected by FA-PMo4V8 with the linear range of 0.2–500 μM at limit of detection of 0.311 μM. FA-PMo4V8 was easily fabricated and exhibited good selectivity, reproducible and sensitivity for detecting H2O2 and sarcosine in broader pH range. FA-PMo4V8 further discriminated PCa patients and healthy persons based on urinary sarcosine concentrations. This study demonstrated that FA-PMo4V8 is simply designed and accurate in colorimetric detection of urinary sarcosine, which could be useful for clinical applications.</description><identifier>ISSN: 0925-4005</identifier><identifier>EISSN: 1873-3077</identifier><identifier>DOI: 10.1016/j.snb.2019.127429</identifier><language>eng</language><publisher>Lausanne: Elsevier B.V</publisher><subject>Biomarkers ; Colorimetric assay ; Colorimetry ; Folate acid functionalization ; Glycine ; H2O2 ; Hydrogen peroxide ; Nanoparticles ; Oxidation ; Peroxidase ; Polyoxometalate ; Prostate ; Sarcosine ; Selectivity</subject><ispartof>Sensors and actuators. B, Chemical, 2020-02, Vol.304, p.127429, Article 127429</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright Elsevier Science Ltd. 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B, Chemical</title><description>[Display omitted] •FA-PMo4V8 is used in colorimetric assay of H2O2 with detection limit as 0.012 μM.•FA-PMo4V8 catalyzes sarcosine in O2 to generate H2O2 without sarcosine oxidase.•FA-PMo4V8 showed high selectivity and detection limit of 0.311 μM for sarcosine.•Sarcosine in urine is detected with recoveries range 97.8–104.3 % with CV &lt; 7 %.•Sarcosine is detected in prostate cancer urine by FA-PMo4V8. The colorimetric detection of sarcosine, a possible biomarker of prostate cancer (PCa), is long-standing research interest and challenge. Folate functionalized polyoxometalate (FA-PMo4V8) was designed and found to detect H2O2 and sarcosine without using peroxidase and sarcosine oxidase (SOD) in 3,3,5,5-tetramethylbezidine (TMB) colorimetric reaction. At optimal condition, FA-PMo4V8 exhibited excellent peroxidase-like activity and catalyzed the oxidation of TMB during detection of H2O2 concentrations in the linear range of 0.007 to 4 μM at limit of detection of 0.012 μM. Also, FA-PMo4V8 was found to mimic SOD by reacting with sarcosine in the presence of oxygen to generate H2O2, glycine and formaldehyde. Sarcosine concentrations were indirectly detected by FA-PMo4V8 with the linear range of 0.2–500 μM at limit of detection of 0.311 μM. FA-PMo4V8 was easily fabricated and exhibited good selectivity, reproducible and sensitivity for detecting H2O2 and sarcosine in broader pH range. FA-PMo4V8 further discriminated PCa patients and healthy persons based on urinary sarcosine concentrations. This study demonstrated that FA-PMo4V8 is simply designed and accurate in colorimetric detection of urinary sarcosine, which could be useful for clinical applications.</description><subject>Biomarkers</subject><subject>Colorimetric assay</subject><subject>Colorimetry</subject><subject>Folate acid functionalization</subject><subject>Glycine</subject><subject>H2O2</subject><subject>Hydrogen peroxide</subject><subject>Nanoparticles</subject><subject>Oxidation</subject><subject>Peroxidase</subject><subject>Polyoxometalate</subject><subject>Prostate</subject><subject>Sarcosine</subject><subject>Selectivity</subject><issn>0925-4005</issn><issn>1873-3077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE9rGzEQxUVoIK6TD5CboOd1RiPtP3oqpq4LgVzas1CkEchsJFfSlrrkw2dd59zTwMx7j3k_xu4FbASI7uGwKfF5gyDGjcBe4XjFVmLoZSOh7z-wFYzYNgqgvWEfSzkAgJIdrNjrzjznYE0NKfLkuU-TqcT9HO15Zabwlxw_pumU_qQXqubfOZqYjibXYCfiNfESXuapmkhpLtOJO6pkK9_jE3ITHS8m21RCJB4it2lKOSxR-XTLrr2ZCt29zzX7ufv6Y7tvHp--fd9-eWyswqE2g7cDDk605y5I1ksLqjUKpTcIQHZU1HWiQ4djC4OQDpUZJGHvvPMjyDX7dMk95vRrplL1Ic15KVc0StW2CDjgohIXlc2plExeH5c_TT5pAfoMWR_0AlmfIesL5MXz-eKh5f3fgbIuNlC05EJeEGiXwn_cb7RFhtM</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Mbage, Bawa</creator><creator>Li, Yiming</creator><creator>Si, Haipei</creator><creator>Zhang, Xueyan</creator><creator>Li, Yue</creator><creator>Wang, Xiaohong</creator><creator>Salah, Abdulwahab</creator><creator>Zhang, Kaizhi</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20200201</creationdate><title>Fabrication of folate functionalized polyoxometalate nanoparticle to simultaneously detect H2O2 and sarcosine in colorimetry</title><author>Mbage, Bawa ; Li, Yiming ; Si, Haipei ; Zhang, Xueyan ; Li, Yue ; Wang, Xiaohong ; Salah, Abdulwahab ; Zhang, Kaizhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-8fc828d1530772ecf3c045a423fa200ec94e66162d2950813d24a83e27dfdf903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomarkers</topic><topic>Colorimetric assay</topic><topic>Colorimetry</topic><topic>Folate acid functionalization</topic><topic>Glycine</topic><topic>H2O2</topic><topic>Hydrogen peroxide</topic><topic>Nanoparticles</topic><topic>Oxidation</topic><topic>Peroxidase</topic><topic>Polyoxometalate</topic><topic>Prostate</topic><topic>Sarcosine</topic><topic>Selectivity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mbage, Bawa</creatorcontrib><creatorcontrib>Li, Yiming</creatorcontrib><creatorcontrib>Si, Haipei</creatorcontrib><creatorcontrib>Zhang, Xueyan</creatorcontrib><creatorcontrib>Li, Yue</creatorcontrib><creatorcontrib>Wang, Xiaohong</creatorcontrib><creatorcontrib>Salah, Abdulwahab</creatorcontrib><creatorcontrib>Zhang, Kaizhi</creatorcontrib><collection>CrossRef</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Sensors and actuators. B, Chemical</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mbage, Bawa</au><au>Li, Yiming</au><au>Si, Haipei</au><au>Zhang, Xueyan</au><au>Li, Yue</au><au>Wang, Xiaohong</au><au>Salah, Abdulwahab</au><au>Zhang, Kaizhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fabrication of folate functionalized polyoxometalate nanoparticle to simultaneously detect H2O2 and sarcosine in colorimetry</atitle><jtitle>Sensors and actuators. B, Chemical</jtitle><date>2020-02-01</date><risdate>2020</risdate><volume>304</volume><spage>127429</spage><pages>127429-</pages><artnum>127429</artnum><issn>0925-4005</issn><eissn>1873-3077</eissn><abstract>[Display omitted] •FA-PMo4V8 is used in colorimetric assay of H2O2 with detection limit as 0.012 μM.•FA-PMo4V8 catalyzes sarcosine in O2 to generate H2O2 without sarcosine oxidase.•FA-PMo4V8 showed high selectivity and detection limit of 0.311 μM for sarcosine.•Sarcosine in urine is detected with recoveries range 97.8–104.3 % with CV &lt; 7 %.•Sarcosine is detected in prostate cancer urine by FA-PMo4V8. The colorimetric detection of sarcosine, a possible biomarker of prostate cancer (PCa), is long-standing research interest and challenge. Folate functionalized polyoxometalate (FA-PMo4V8) was designed and found to detect H2O2 and sarcosine without using peroxidase and sarcosine oxidase (SOD) in 3,3,5,5-tetramethylbezidine (TMB) colorimetric reaction. At optimal condition, FA-PMo4V8 exhibited excellent peroxidase-like activity and catalyzed the oxidation of TMB during detection of H2O2 concentrations in the linear range of 0.007 to 4 μM at limit of detection of 0.012 μM. Also, FA-PMo4V8 was found to mimic SOD by reacting with sarcosine in the presence of oxygen to generate H2O2, glycine and formaldehyde. Sarcosine concentrations were indirectly detected by FA-PMo4V8 with the linear range of 0.2–500 μM at limit of detection of 0.311 μM. FA-PMo4V8 was easily fabricated and exhibited good selectivity, reproducible and sensitivity for detecting H2O2 and sarcosine in broader pH range. FA-PMo4V8 further discriminated PCa patients and healthy persons based on urinary sarcosine concentrations. This study demonstrated that FA-PMo4V8 is simply designed and accurate in colorimetric detection of urinary sarcosine, which could be useful for clinical applications.</abstract><cop>Lausanne</cop><pub>Elsevier B.V</pub><doi>10.1016/j.snb.2019.127429</doi></addata></record>
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subjects Biomarkers
Colorimetric assay
Colorimetry
Folate acid functionalization
Glycine
H2O2
Hydrogen peroxide
Nanoparticles
Oxidation
Peroxidase
Polyoxometalate
Prostate
Sarcosine
Selectivity
title Fabrication of folate functionalized polyoxometalate nanoparticle to simultaneously detect H2O2 and sarcosine in colorimetry
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