Semicarbazide-Sensitive Amine Oxidase Increases in Calcific Aortic Valve Stenosis and Contributes to Valvular Interstitial Cell Calcification

Introduction. Calcific aortic valve stenosis (CAVS) is a common disease associated with aging. Oxidative stress participates in the valve calcification process in CAVS. Semicarbazide-sensitive amine oxidase (SSAO), also referred to as vascular adhesion protein 1 (VAP-1), transforms primary amines in...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2020, Vol.2020 (2020), p.1-9, Article 5197376
Hauptverfasser:	Bäck, Magnus, Wollensack, Bastien, Persson, Oscar, Carracedo, Miguel, Pirault, John, Pawelzik, Sven-Christian, Mercier, Nathalie, Franco-Cereceda, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	Amine Oxidase (Copper-Containing) - antagonists & inhibitors Amine Oxidase (Copper-Containing) - genetics Amine Oxidase (Copper-Containing) - metabolism Analysis Aortic Valve - enzymology Aortic Valve - pathology Aortic valve stenosis Aortic Valve Stenosis - enzymology Aortic Valve Stenosis - genetics Aortic Valve Stenosis - pathology Calcification Calcinosis - enzymology Calcinosis - genetics Calcinosis - pathology Cell Biology Diabetes Mellitus - enzymology Diabetes Mellitus - genetics Enzymes Gene expression Humans Hydrogen peroxide Immunohistochemistry Laboratories Life Sciences & Biomedicine Medicin och hälsovetenskap Obesity - enzymology Obesity - genetics Oxidases Oxidative Stress Proteins Risk factors RNA RNA, Messenger - genetics RNA, Messenger - metabolism Science & Technology Scientific equipment and supplies industry Smoking - adverse effects Type 2 diabetes
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