Stability of ten psychotropic drugs in formalin-fixed porcine liver homogenates

•Porcine liver homogenates (PLHs) added with psychotropic drugs were formalin-fixed.•Drug concentrations after formalin fixation were analyzed periodically for 6 months.•Residual ratios of all drugs except for estazolam were >10 % after 4 weeks.•Residual ratios of 5 out of 10 drugs were >25 %...

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Veröffentlicht in:	Forensic science international 2020-02, Vol.307, p.110136, Article 110136
Hauptverfasser:	Asano, Migiwa, Yoshioka, Naoki, Kuse, Azumi, Kuwahara, Natsumi, Nakabayashi, Yuki, Takahashi, Motonori, Kondo, Takeshi, Morichika, Mai, Nakagawa, Kanako, Sakurada, Makoto, Ueno, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amitriptyline Animals Benzodiazepines Chemicals Chromatography Chromatography, Liquid Degradation Diazepam Diphenhydramine Drug metabolism Drug Stability Drugs Fixation Fixatives Forensic science Forensic sciences Forensic toxicology Forensic Toxicology - methods Formaldehyde Formalin-fixed tissues Human tissues LC–MS/MS Liquid chromatography Liver Liver - chemistry Mass spectrometry Mass spectroscopy Microwaves Organ Preservation Paroxetine Preservation Psychotropic drugs Psychotropic Drugs - analysis Psychotropic Drugs - chemistry Quetiapine Room temperature Solvents Specimen Handling Stability Swine Tandem Mass Spectrometry Time dependence Tissues Toxicology Triazolam Vortices
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