Effect of Triclosan on the Functioning of Liver Mitochondria and Permeability of Erythrocyte Membranes of Marsh Frog (Pelophylax ridibundus (Pallas, 1771))
The paper examines the effects of the antimicrobial agent triclosan on the functioning of the liver mitochondria of marsh frog ( Pelophylax ridibundus (Pallas, 1771)). It was established that triclosan inhibits DNP-stimulated respiration of mitochondria and decreases respiratory control ratio. In ad...
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| Veröffentlicht in: | The Journal of membrane biology 2020-02, Vol.253 (1), p.1-10 |
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| creator | Dubinin, Mikhail V. Tenkov, Kirill S. Svinin, Anton O. Samartsev, Victor N. Belosludtsev, Konstantin N. |
| description | The paper examines the effects of the antimicrobial agent triclosan on the functioning of the liver mitochondria of marsh frog (
Pelophylax ridibundus
(Pallas, 1771)). It was established that triclosan inhibits DNP-stimulated respiration of mitochondria and decreases respiratory control ratio. In addition, triclosan causes the collapse of the mitochondrial membrane potential on both types of substrates. Such an action of triclosan can be mediated by both a protonophore effect and suppression of the activity of complex II and combined activity of complexes II + III (and, to a lesser degree, the combined activity of complexes I + III) of the mitochondrial respiratory chain. It is shown that high concentrations of triclosan enhance the production of hydrogen peroxide during the oxidation of substrates of the complex I by mitochondria, and decrease it in the case of succinate oxidation. It is found that triclosan is able to induce nonspecific permeability of the liver mitochondria of these amphibians, as well as the plasma membrane of erythrocytes. The possible mechanisms of triclosan effect on marsh frog liver mitochondria and red blood cells are discussed.
Graphic Abstract |
| doi_str_mv | 10.1007/s00232-019-00099-w |
| format | Article |
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Pelophylax ridibundus
(Pallas, 1771)). It was established that triclosan inhibits DNP-stimulated respiration of mitochondria and decreases respiratory control ratio. In addition, triclosan causes the collapse of the mitochondrial membrane potential on both types of substrates. Such an action of triclosan can be mediated by both a protonophore effect and suppression of the activity of complex II and combined activity of complexes II + III (and, to a lesser degree, the combined activity of complexes I + III) of the mitochondrial respiratory chain. It is shown that high concentrations of triclosan enhance the production of hydrogen peroxide during the oxidation of substrates of the complex I by mitochondria, and decrease it in the case of succinate oxidation. It is found that triclosan is able to induce nonspecific permeability of the liver mitochondria of these amphibians, as well as the plasma membrane of erythrocytes. The possible mechanisms of triclosan effect on marsh frog liver mitochondria and red blood cells are discussed.
Graphic Abstract</description><identifier>ISSN: 0022-2631</identifier><identifier>EISSN: 1432-1424</identifier><identifier>DOI: 10.1007/s00232-019-00099-w</identifier><identifier>PMID: 31598758</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Amphibians ; Animals ; Antimicrobial agents ; Biochemistry ; Biomedical and Life Sciences ; Cell Membrane Permeability - drug effects ; Cell Respiration - drug effects ; Collapse ; Dose-Response Relationship, Drug ; Electron transport chain ; Electron Transport Chain Complex Proteins - metabolism ; Erythrocyte Membrane - metabolism ; Erythrocytes ; Human Physiology ; Hydrogen peroxide ; Hydrogen Peroxide - metabolism ; Hydrogen production ; Life Sciences ; Liver ; Membrane permeability ; Membrane potential ; Membrane Potential, Mitochondrial - drug effects ; Membranes ; Mitochondria ; Mitochondria, Liver - drug effects ; Mitochondria, Liver - metabolism ; Oxidation ; Oxidative Phosphorylation - drug effects ; Pelophylax ridibundus ; Permeability ; Ranidae ; Substrates ; Triclosan ; Triclosan - pharmacology</subject><ispartof>The Journal of membrane biology, 2020-02, Vol.253 (1), p.1-10</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>The Journal of Membrane Biology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-8b489493f7d95399b99f5829a94e95ff84cb4342c054cb43eaaf6b56949c59ed3</citedby><cites>FETCH-LOGICAL-c375t-8b489493f7d95399b99f5829a94e95ff84cb4342c054cb43eaaf6b56949c59ed3</cites><orcidid>0000-0002-7453-3390</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00232-019-00099-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00232-019-00099-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31598758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dubinin, Mikhail V.</creatorcontrib><creatorcontrib>Tenkov, Kirill S.</creatorcontrib><creatorcontrib>Svinin, Anton O.</creatorcontrib><creatorcontrib>Samartsev, Victor N.</creatorcontrib><creatorcontrib>Belosludtsev, Konstantin N.</creatorcontrib><title>Effect of Triclosan on the Functioning of Liver Mitochondria and Permeability of Erythrocyte Membranes of Marsh Frog (Pelophylax ridibundus (Pallas, 1771))</title><title>The Journal of membrane biology</title><addtitle>J Membrane Biol</addtitle><addtitle>J Membr Biol</addtitle><description>The paper examines the effects of the antimicrobial agent triclosan on the functioning of the liver mitochondria of marsh frog (
Pelophylax ridibundus
(Pallas, 1771)). It was established that triclosan inhibits DNP-stimulated respiration of mitochondria and decreases respiratory control ratio. In addition, triclosan causes the collapse of the mitochondrial membrane potential on both types of substrates. Such an action of triclosan can be mediated by both a protonophore effect and suppression of the activity of complex II and combined activity of complexes II + III (and, to a lesser degree, the combined activity of complexes I + III) of the mitochondrial respiratory chain. It is shown that high concentrations of triclosan enhance the production of hydrogen peroxide during the oxidation of substrates of the complex I by mitochondria, and decrease it in the case of succinate oxidation. It is found that triclosan is able to induce nonspecific permeability of the liver mitochondria of these amphibians, as well as the plasma membrane of erythrocytes. The possible mechanisms of triclosan effect on marsh frog liver mitochondria and red blood cells are discussed.
Graphic Abstract</description><subject>Amphibians</subject><subject>Animals</subject><subject>Antimicrobial agents</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Membrane Permeability - drug effects</subject><subject>Cell Respiration - drug effects</subject><subject>Collapse</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electron transport chain</subject><subject>Electron Transport Chain Complex Proteins - metabolism</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Erythrocytes</subject><subject>Human Physiology</subject><subject>Hydrogen peroxide</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>Hydrogen production</subject><subject>Life Sciences</subject><subject>Liver</subject><subject>Membrane permeability</subject><subject>Membrane potential</subject><subject>Membrane Potential, Mitochondrial - drug effects</subject><subject>Membranes</subject><subject>Mitochondria</subject><subject>Mitochondria, Liver - drug effects</subject><subject>Mitochondria, Liver - metabolism</subject><subject>Oxidation</subject><subject>Oxidative Phosphorylation - drug effects</subject><subject>Pelophylax ridibundus</subject><subject>Permeability</subject><subject>Ranidae</subject><subject>Substrates</subject><subject>Triclosan</subject><subject>Triclosan - pharmacology</subject><issn>0022-2631</issn><issn>1432-1424</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kctOGzEUhi1EBYH2BVhUltiA1Gl9zYyXCCVtpURlQdeWx2NnjCZ2anug8yx9WRwC7a4rW-e_nCN9AFxg9BkjVH9JCBFKKoRFhRASono6AjPMyggzwo7BrOikInOKT8FZSg8I4bqesxNwSjEXTc2bGfizsNboDIOF99HpISTlYfAw9wYuR6-zC975zV5fuUcT4drloPvgu-gUVL6DdyZujWrd4PK0ty3ilPsY9JQNXJttG5U3aS-sVUw9XMawgVd3Zgi7fhrUbxhd59rRd2MqYzUMKn2C5U58ff0evLNqSObD63sOfi4X97ffqtWPr99vb1aVpjXPVdOyRjBBbd0JToVohbC8IUIJZgS3tmG6ZZQRjfjLzyhl5y2fl4zmwnT0HFweencx_BpNyvIhjNGXlZJQxghuhMDFRQ4uHUNK0Vi5i26r4iQxknse8sBDFh7yhYd8KqGPr9VjuzXd38gbgGKgB0Mqkt-Y-G_3f2qfAeRklu4</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Dubinin, Mikhail V.</creator><creator>Tenkov, Kirill S.</creator><creator>Svinin, Anton O.</creator><creator>Samartsev, Victor N.</creator><creator>Belosludtsev, Konstantin N.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-7453-3390</orcidid></search><sort><creationdate>20200201</creationdate><title>Effect of Triclosan on the Functioning of Liver Mitochondria and Permeability of Erythrocyte Membranes of Marsh Frog (Pelophylax ridibundus (Pallas, 1771))</title><author>Dubinin, Mikhail V. ; Tenkov, Kirill S. ; Svinin, Anton O. ; Samartsev, Victor N. ; Belosludtsev, Konstantin N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-8b489493f7d95399b99f5829a94e95ff84cb4342c054cb43eaaf6b56949c59ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amphibians</topic><topic>Animals</topic><topic>Antimicrobial agents</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Membrane Permeability - drug effects</topic><topic>Cell Respiration - drug effects</topic><topic>Collapse</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electron transport chain</topic><topic>Electron Transport Chain Complex Proteins - metabolism</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Erythrocytes</topic><topic>Human Physiology</topic><topic>Hydrogen peroxide</topic><topic>Hydrogen Peroxide - metabolism</topic><topic>Hydrogen production</topic><topic>Life Sciences</topic><topic>Liver</topic><topic>Membrane permeability</topic><topic>Membrane potential</topic><topic>Membrane Potential, Mitochondrial - drug effects</topic><topic>Membranes</topic><topic>Mitochondria</topic><topic>Mitochondria, Liver - drug effects</topic><topic>Mitochondria, Liver - metabolism</topic><topic>Oxidation</topic><topic>Oxidative Phosphorylation - drug effects</topic><topic>Pelophylax ridibundus</topic><topic>Permeability</topic><topic>Ranidae</topic><topic>Substrates</topic><topic>Triclosan</topic><topic>Triclosan - 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Pelophylax ridibundus
(Pallas, 1771)). It was established that triclosan inhibits DNP-stimulated respiration of mitochondria and decreases respiratory control ratio. In addition, triclosan causes the collapse of the mitochondrial membrane potential on both types of substrates. Such an action of triclosan can be mediated by both a protonophore effect and suppression of the activity of complex II and combined activity of complexes II + III (and, to a lesser degree, the combined activity of complexes I + III) of the mitochondrial respiratory chain. It is shown that high concentrations of triclosan enhance the production of hydrogen peroxide during the oxidation of substrates of the complex I by mitochondria, and decrease it in the case of succinate oxidation. It is found that triclosan is able to induce nonspecific permeability of the liver mitochondria of these amphibians, as well as the plasma membrane of erythrocytes. The possible mechanisms of triclosan effect on marsh frog liver mitochondria and red blood cells are discussed.
Graphic Abstract</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31598758</pmid><doi>10.1007/s00232-019-00099-w</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7453-3390</orcidid></addata></record> |
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| subjects | Amphibians Animals Antimicrobial agents Biochemistry Biomedical and Life Sciences Cell Membrane Permeability - drug effects Cell Respiration - drug effects Collapse Dose-Response Relationship, Drug Electron transport chain Electron Transport Chain Complex Proteins - metabolism Erythrocyte Membrane - metabolism Erythrocytes Human Physiology Hydrogen peroxide Hydrogen Peroxide - metabolism Hydrogen production Life Sciences Liver Membrane permeability Membrane potential Membrane Potential, Mitochondrial - drug effects Membranes Mitochondria Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Oxidation Oxidative Phosphorylation - drug effects Pelophylax ridibundus Permeability Ranidae Substrates Triclosan Triclosan - pharmacology |
| title | Effect of Triclosan on the Functioning of Liver Mitochondria and Permeability of Erythrocyte Membranes of Marsh Frog (Pelophylax ridibundus (Pallas, 1771)) |
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