Tacrolimus blood concentration increase depends on administration route when combined with voriconazole in pediatric stem cell transplant recipients

Background Understanding of TAC pharmacokinetics is required to avoid both overdosing and underdosing. VRCZ is known to increase the TAC blood concentration by inhibiting CYP3A4; however, detailed, practical information on pediatric cases is still scarce. Herein, we investigated the association betw...

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Veröffentlicht in:	Pediatric transplantation 2020-02, Vol.24 (1), p.e13619-n/a
Hauptverfasser:	Utano, Tomoyuki, Kato, Motohiro, Osumi, Tomoo, Shioda, Yoko, Kiyotani, Chikako, Terashima, Keita, Tomizawa, Daisuke, Matsumoto, Kimikazu, Yamatani, Akimasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Antifungal agents Blood levels Child Child, Preschool Children Dosage Dose-Response Relationship, Drug Drug Administration Schedule drug interaction Drug Therapy, Combination Female Graft Rejection - prevention & control Hematopoietic Stem Cell Transplantation Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - blood Immunosuppressive Agents - pharmacokinetics Immunosuppressive Agents - therapeutic use Infant Infusions, Intravenous Intravenous administration Linear Models Male Oral administration Patients Pediatrics Pharmacokinetics Retrospective Studies Stem cell transplantation Stem cells Tacrolimus Tacrolimus - administration & dosage Tacrolimus - blood Tacrolimus - pharmacokinetics Tacrolimus - therapeutic use Transplants & implants Voriconazole Voriconazole - administration & dosage Voriconazole - blood Voriconazole - pharmacokinetics Voriconazole - therapeutic use
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