Synthesis of carboxy‐polyethylene glycol‐amine (CA (PEG)n) and [1‐14C]‐CA (PEG)n via oxa‐Michael addition of amino‐polyethylene glycols to propiolates vs to acrylates

Synthesis of carboxy‐polyethylene glycol‐amine (CA (PEG)n) via oxa‐Michael addition of amino‐polyethylene glycols to either acrylates or propiolates was investigated. Compared with the oxa‐Michael addition to acrylates, the corresponding addition to propiolates was found to proceed under mild reacti...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 2020-01, Vol.63 (1), p.15-24
Hauptverfasser:	Song, Fengbin, Chen, Lu, Lin, Ronghui, Salter, Rhys
Format:	Artikel
Sprache:	eng
Schlagworte:	[1‐14C]‐propiolate Acrylates Acrylates - chemistry Adducts Amines - chemistry bifunctional crosslinker Carbon Radioisotopes - chemistry carbon‐14 carboxy‐polyethylene glycol‐amine Chemical industry Chemistry Techniques, Synthetic oxa‐Michael addition Polyethylene glycol Polyethylene Glycols - chemistry radiolabeling Substrates Synthesis
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