Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry
Background High prevalence of arterial hypertension is known in pediatric renal transplant patients, but how blood pressure (BP) distribution and control differ between age groups and whether sex and age interact and potentially impact BP after transplantation have not been investigated. Methods Thi...
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Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2020-03, Vol.35 (3), p.415-426 |
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creator | Sugianto, Rizky I. Schmidt, Bernhard M. W. Memaran, Nima Duzova, Ali Topaloglu, Rezan Seeman, Tomas König, Sabine Dello Strologo, Luca Murer, Luisa Özçakar, Zeynep Birsin Bald, Martin Shenoy, Mohan Buescher, Anja Hoyer, Peter F. Pohl, Michael Billing, Heiko Oh, Jun Staude, Hagen Pohl, Martin Genc, Gurkan Klaus, Günter Alparslan, Caner Grenda, Ryszard Rubik, Jacek Krupka, Kai Tönshoff, Burkhard Wühl, Elke Melk, Anette |
description | Background
High prevalence of arterial hypertension is known in pediatric renal transplant patients, but how blood pressure (BP) distribution and control differ between age groups and whether sex and age interact and potentially impact BP after transplantation have not been investigated.
Methods
This retrospective analysis included 336 pediatric renal transplant recipients (62% males) from the Cooperative European Pediatric Renal Transplant Initiative Registry (CERTAIN) with complete BP measurement at discharge and 1, 2 and 3 years post-transplant.
Results
At discharge and 3 years post-transplant, arterial hypertension was highly prevalent (84% and 77%); antihypertensive drugs were used in 73% and 68% of the patients. 27% suffered from uncontrolled and 9% from untreated hypertension at 3 years post-transplant. Children transplanted at age < 5 years showed sustained high systolic BP
z
-score and received consistently less antihypertensive treatment over time. Younger age, shorter time since transplantation, male sex, higher body mass index (BMI), high cyclosporine A (CSA) trough levels, and a primary renal disease other than congenital anomalies of the kidney and urinary tract (CAKUT) were significantly associated with higher systolic BP
z
-score. Sex-stratified analysis revealed a significant association between high CSA and higher systolic BP in older girls that likely had started puberty already. An association between BP and estimated glomerular filtration rate was not detected.
Conclusions
BP control during the first 3 years was poor in this large European cohort. The description of age- and sex-specific risk profiles identified certain recipient groups that may benefit from more frequent BP monitoring (i.e. young children) or different choices of immunosuppression (i.e. older girls). |
doi_str_mv | 10.1007/s00467-019-04395-4 |
format | Article |
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High prevalence of arterial hypertension is known in pediatric renal transplant patients, but how blood pressure (BP) distribution and control differ between age groups and whether sex and age interact and potentially impact BP after transplantation have not been investigated.
Methods
This retrospective analysis included 336 pediatric renal transplant recipients (62% males) from the Cooperative European Pediatric Renal Transplant Initiative Registry (CERTAIN) with complete BP measurement at discharge and 1, 2 and 3 years post-transplant.
Results
At discharge and 3 years post-transplant, arterial hypertension was highly prevalent (84% and 77%); antihypertensive drugs were used in 73% and 68% of the patients. 27% suffered from uncontrolled and 9% from untreated hypertension at 3 years post-transplant. Children transplanted at age < 5 years showed sustained high systolic BP
z
-score and received consistently less antihypertensive treatment over time. Younger age, shorter time since transplantation, male sex, higher body mass index (BMI), high cyclosporine A (CSA) trough levels, and a primary renal disease other than congenital anomalies of the kidney and urinary tract (CAKUT) were significantly associated with higher systolic BP
z
-score. Sex-stratified analysis revealed a significant association between high CSA and higher systolic BP in older girls that likely had started puberty already. An association between BP and estimated glomerular filtration rate was not detected.
Conclusions
BP control during the first 3 years was poor in this large European cohort. The description of age- and sex-specific risk profiles identified certain recipient groups that may benefit from more frequent BP monitoring (i.e. young children) or different choices of immunosuppression (i.e. older girls).</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s00467-019-04395-4</identifier><identifier>PMID: 31811541</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject><![CDATA[Adolescent ; Age ; Age Factors ; Antihypertensives ; Blood pressure ; Blood Pressure Determination - statistics & numerical data ; Body mass index ; Cardiovascular diseases ; Child ; Child, Preschool ; Children ; Complications and side effects ; Congenital defects ; Cyclosporine - administration & dosage ; Cyclosporine - adverse effects ; Cyclosporine - pharmacokinetics ; Cyclosporins ; Diagnosis ; Europe - epidemiology ; Female ; Follow-Up Studies ; Glomerular filtration rate ; Graft Rejection - immunology ; Graft Rejection - prevention & control ; Health risk assessment ; Humans ; Hypertension ; Hypertension - diagnosis ; Hypertension - epidemiology ; Hypertension - etiology ; Immunosuppression ; Immunosuppressive agents ; Immunosuppressive Agents - administration & dosage ; Immunosuppressive Agents - adverse effects ; Immunosuppressive Agents - pharmacokinetics ; Kidney transplantation ; Kidney Transplantation - adverse effects ; Kidney transplants ; Kidneys ; Longitudinal Studies ; Male ; Medicine ; Medicine & Public Health ; Nephrology ; Original Article ; Patients ; Pediatric research ; Pediatrics ; Prevalence ; Puberty ; Registries - statistics & numerical data ; Retrospective Studies ; Risk factors ; Sex ; Sex Factors ; Tacrolimus - administration & dosage ; Tacrolimus - adverse effects ; Tacrolimus - pharmacokinetics ; Time Factors ; Transplant Recipients - statistics & numerical data ; Transplantation ; Transplants & implants ; Urinary tract ; Urology ; What’s new in Hypertension]]></subject><ispartof>Pediatric nephrology (Berlin, West), 2020-03, Vol.35 (3), p.415-426</ispartof><rights>IPNA 2019</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Pediatric Nephrology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-627ea91d5d4a745affefbdcf37ad41c5da805aeba0b5af1dbf204e0604ad8e873</citedby><cites>FETCH-LOGICAL-c511t-627ea91d5d4a745affefbdcf37ad41c5da805aeba0b5af1dbf204e0604ad8e873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00467-019-04395-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00467-019-04395-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31811541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugianto, Rizky I.</creatorcontrib><creatorcontrib>Schmidt, Bernhard M. W.</creatorcontrib><creatorcontrib>Memaran, Nima</creatorcontrib><creatorcontrib>Duzova, Ali</creatorcontrib><creatorcontrib>Topaloglu, Rezan</creatorcontrib><creatorcontrib>Seeman, Tomas</creatorcontrib><creatorcontrib>König, Sabine</creatorcontrib><creatorcontrib>Dello Strologo, Luca</creatorcontrib><creatorcontrib>Murer, Luisa</creatorcontrib><creatorcontrib>Özçakar, Zeynep Birsin</creatorcontrib><creatorcontrib>Bald, Martin</creatorcontrib><creatorcontrib>Shenoy, Mohan</creatorcontrib><creatorcontrib>Buescher, Anja</creatorcontrib><creatorcontrib>Hoyer, Peter F.</creatorcontrib><creatorcontrib>Pohl, Michael</creatorcontrib><creatorcontrib>Billing, Heiko</creatorcontrib><creatorcontrib>Oh, Jun</creatorcontrib><creatorcontrib>Staude, Hagen</creatorcontrib><creatorcontrib>Pohl, Martin</creatorcontrib><creatorcontrib>Genc, Gurkan</creatorcontrib><creatorcontrib>Klaus, Günter</creatorcontrib><creatorcontrib>Alparslan, Caner</creatorcontrib><creatorcontrib>Grenda, Ryszard</creatorcontrib><creatorcontrib>Rubik, Jacek</creatorcontrib><creatorcontrib>Krupka, Kai</creatorcontrib><creatorcontrib>Tönshoff, Burkhard</creatorcontrib><creatorcontrib>Wühl, Elke</creatorcontrib><creatorcontrib>Melk, Anette</creatorcontrib><title>Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><addtitle>Pediatr Nephrol</addtitle><description>Background
High prevalence of arterial hypertension is known in pediatric renal transplant patients, but how blood pressure (BP) distribution and control differ between age groups and whether sex and age interact and potentially impact BP after transplantation have not been investigated.
Methods
This retrospective analysis included 336 pediatric renal transplant recipients (62% males) from the Cooperative European Pediatric Renal Transplant Initiative Registry (CERTAIN) with complete BP measurement at discharge and 1, 2 and 3 years post-transplant.
Results
At discharge and 3 years post-transplant, arterial hypertension was highly prevalent (84% and 77%); antihypertensive drugs were used in 73% and 68% of the patients. 27% suffered from uncontrolled and 9% from untreated hypertension at 3 years post-transplant. Children transplanted at age < 5 years showed sustained high systolic BP
z
-score and received consistently less antihypertensive treatment over time. Younger age, shorter time since transplantation, male sex, higher body mass index (BMI), high cyclosporine A (CSA) trough levels, and a primary renal disease other than congenital anomalies of the kidney and urinary tract (CAKUT) were significantly associated with higher systolic BP
z
-score. Sex-stratified analysis revealed a significant association between high CSA and higher systolic BP in older girls that likely had started puberty already. An association between BP and estimated glomerular filtration rate was not detected.
Conclusions
BP control during the first 3 years was poor in this large European cohort. The description of age- and sex-specific risk profiles identified certain recipient groups that may benefit from more frequent BP monitoring (i.e. young children) or different choices of immunosuppression (i.e. older girls).</description><subject>Adolescent</subject><subject>Age</subject><subject>Age Factors</subject><subject>Antihypertensives</subject><subject>Blood pressure</subject><subject>Blood Pressure Determination - statistics & numerical data</subject><subject>Body mass index</subject><subject>Cardiovascular diseases</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Complications and side effects</subject><subject>Congenital defects</subject><subject>Cyclosporine - administration & dosage</subject><subject>Cyclosporine - adverse effects</subject><subject>Cyclosporine - pharmacokinetics</subject><subject>Cyclosporins</subject><subject>Diagnosis</subject><subject>Europe - epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glomerular filtration rate</subject><subject>Graft Rejection - immunology</subject><subject>Graft Rejection - prevention & control</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - diagnosis</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - etiology</subject><subject>Immunosuppression</subject><subject>Immunosuppressive agents</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Immunosuppressive Agents - pharmacokinetics</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidney transplants</subject><subject>Kidneys</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Patients</subject><subject>Pediatric research</subject><subject>Pediatrics</subject><subject>Prevalence</subject><subject>Puberty</subject><subject>Registries - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>Risk factors</subject><subject>Sex</subject><subject>Sex Factors</subject><subject>Tacrolimus - administration & dosage</subject><subject>Tacrolimus - adverse effects</subject><subject>Tacrolimus - pharmacokinetics</subject><subject>Time Factors</subject><subject>Transplant Recipients - statistics & numerical data</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>Urinary tract</subject><subject>Urology</subject><subject>What’s new in Hypertension</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kmFr1TAUhoso7m76B_wgAcFvnUmbtqnfLpc5B0NhTti3cNqctBm9SU1S2P0R_mcz73QOLhJI4Jznfck5vFn2htFTRmnzIVDK6yanrM0pL9sq58-yFeNlkbNW3DzPVrQtWWqxm6PsOIRbSqmoRP0yOyqZYKzibJX9_IZ3BKwiMCCBQBRG9FtjwcZAtPNkNMNIusk5RWaPISweibFkRmUgetMTjxYmEj3YME9Jlgq9mQ0mg48EyOTsYOKizD0F6doFE4jTJI5INmdX1-uLL-QKBxOi373KXmiYAr5-eE-y75_Orjef88uv5xeb9WXeV4zFvC4ahJapSnFoeAVao-5Ur8sGFGd9pUDQCrAD2qUmU50uKEdaUw5KoGjKk-zd3nf27seCIcpbt_j0uSCLkpdV05ZCPFIDTCiN1S5N2W9N6OW6ZqxuGi6KROUHqAEtekjDozap_IQ_PcCno3Br-oOC9_8IRoQpjsFNSzTOhqdgsQd770LwqOXszRb8TjIq7xMj94mRKTHyd2IkT6K3D6tYui2qv5I_EUlAuQdCatkB_eOu_mP7CyClzDA</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Sugianto, Rizky I.</creator><creator>Schmidt, Bernhard M. W.</creator><creator>Memaran, Nima</creator><creator>Duzova, Ali</creator><creator>Topaloglu, Rezan</creator><creator>Seeman, Tomas</creator><creator>König, Sabine</creator><creator>Dello Strologo, Luca</creator><creator>Murer, Luisa</creator><creator>Özçakar, Zeynep Birsin</creator><creator>Bald, Martin</creator><creator>Shenoy, Mohan</creator><creator>Buescher, Anja</creator><creator>Hoyer, Peter F.</creator><creator>Pohl, Michael</creator><creator>Billing, Heiko</creator><creator>Oh, Jun</creator><creator>Staude, Hagen</creator><creator>Pohl, Martin</creator><creator>Genc, Gurkan</creator><creator>Klaus, Günter</creator><creator>Alparslan, Caner</creator><creator>Grenda, Ryszard</creator><creator>Rubik, Jacek</creator><creator>Krupka, Kai</creator><creator>Tönshoff, Burkhard</creator><creator>Wühl, Elke</creator><creator>Melk, Anette</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20200301</creationdate><title>Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry</title><author>Sugianto, Rizky I. ; Schmidt, Bernhard M. W. ; Memaran, Nima ; Duzova, Ali ; Topaloglu, Rezan ; Seeman, Tomas ; König, Sabine ; Dello Strologo, Luca ; Murer, Luisa ; Özçakar, Zeynep Birsin ; Bald, Martin ; Shenoy, Mohan ; Buescher, Anja ; Hoyer, Peter F. ; Pohl, Michael ; Billing, Heiko ; Oh, Jun ; Staude, Hagen ; Pohl, Martin ; Genc, Gurkan ; Klaus, Günter ; Alparslan, Caner ; Grenda, Ryszard ; Rubik, Jacek ; Krupka, Kai ; Tönshoff, Burkhard ; Wühl, Elke ; Melk, Anette</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-627ea91d5d4a745affefbdcf37ad41c5da805aeba0b5af1dbf204e0604ad8e873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Age</topic><topic>Age Factors</topic><topic>Antihypertensives</topic><topic>Blood pressure</topic><topic>Blood Pressure Determination - statistics & numerical data</topic><topic>Body mass index</topic><topic>Cardiovascular diseases</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Complications and side effects</topic><topic>Congenital defects</topic><topic>Cyclosporine - administration & dosage</topic><topic>Cyclosporine - adverse effects</topic><topic>Cyclosporine - pharmacokinetics</topic><topic>Cyclosporins</topic><topic>Diagnosis</topic><topic>Europe - epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glomerular filtration rate</topic><topic>Graft Rejection - immunology</topic><topic>Graft Rejection - prevention & control</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - diagnosis</topic><topic>Hypertension - epidemiology</topic><topic>Hypertension - etiology</topic><topic>Immunosuppression</topic><topic>Immunosuppressive agents</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Immunosuppressive Agents - pharmacokinetics</topic><topic>Kidney transplantation</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Kidney transplants</topic><topic>Kidneys</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Patients</topic><topic>Pediatric research</topic><topic>Pediatrics</topic><topic>Prevalence</topic><topic>Puberty</topic><topic>Registries - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>Risk factors</topic><topic>Sex</topic><topic>Sex Factors</topic><topic>Tacrolimus - administration & dosage</topic><topic>Tacrolimus - adverse effects</topic><topic>Tacrolimus - pharmacokinetics</topic><topic>Time Factors</topic><topic>Transplant Recipients - statistics & numerical data</topic><topic>Transplantation</topic><topic>Transplants & implants</topic><topic>Urinary tract</topic><topic>Urology</topic><topic>What’s new in Hypertension</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sugianto, Rizky I.</creatorcontrib><creatorcontrib>Schmidt, Bernhard M. 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W.</au><au>Memaran, Nima</au><au>Duzova, Ali</au><au>Topaloglu, Rezan</au><au>Seeman, Tomas</au><au>König, Sabine</au><au>Dello Strologo, Luca</au><au>Murer, Luisa</au><au>Özçakar, Zeynep Birsin</au><au>Bald, Martin</au><au>Shenoy, Mohan</au><au>Buescher, Anja</au><au>Hoyer, Peter F.</au><au>Pohl, Michael</au><au>Billing, Heiko</au><au>Oh, Jun</au><au>Staude, Hagen</au><au>Pohl, Martin</au><au>Genc, Gurkan</au><au>Klaus, Günter</au><au>Alparslan, Caner</au><au>Grenda, Ryszard</au><au>Rubik, Jacek</au><au>Krupka, Kai</au><au>Tönshoff, Burkhard</au><au>Wühl, Elke</au><au>Melk, Anette</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><stitle>Pediatr Nephrol</stitle><addtitle>Pediatr Nephrol</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>35</volume><issue>3</issue><spage>415</spage><epage>426</epage><pages>415-426</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><abstract>Background
High prevalence of arterial hypertension is known in pediatric renal transplant patients, but how blood pressure (BP) distribution and control differ between age groups and whether sex and age interact and potentially impact BP after transplantation have not been investigated.
Methods
This retrospective analysis included 336 pediatric renal transplant recipients (62% males) from the Cooperative European Pediatric Renal Transplant Initiative Registry (CERTAIN) with complete BP measurement at discharge and 1, 2 and 3 years post-transplant.
Results
At discharge and 3 years post-transplant, arterial hypertension was highly prevalent (84% and 77%); antihypertensive drugs were used in 73% and 68% of the patients. 27% suffered from uncontrolled and 9% from untreated hypertension at 3 years post-transplant. Children transplanted at age < 5 years showed sustained high systolic BP
z
-score and received consistently less antihypertensive treatment over time. Younger age, shorter time since transplantation, male sex, higher body mass index (BMI), high cyclosporine A (CSA) trough levels, and a primary renal disease other than congenital anomalies of the kidney and urinary tract (CAKUT) were significantly associated with higher systolic BP
z
-score. Sex-stratified analysis revealed a significant association between high CSA and higher systolic BP in older girls that likely had started puberty already. An association between BP and estimated glomerular filtration rate was not detected.
Conclusions
BP control during the first 3 years was poor in this large European cohort. The description of age- and sex-specific risk profiles identified certain recipient groups that may benefit from more frequent BP monitoring (i.e. young children) or different choices of immunosuppression (i.e. older girls).</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31811541</pmid><doi>10.1007/s00467-019-04395-4</doi><tpages>12</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0931-041X |
ispartof | Pediatric nephrology (Berlin, West), 2020-03, Vol.35 (3), p.415-426 |
issn | 0931-041X 1432-198X |
language | eng |
recordid | cdi_proquest_journals_2343579388 |
source | MEDLINE; SpringerLink Journals |
subjects | Adolescent Age Age Factors Antihypertensives Blood pressure Blood Pressure Determination - statistics & numerical data Body mass index Cardiovascular diseases Child Child, Preschool Children Complications and side effects Congenital defects Cyclosporine - administration & dosage Cyclosporine - adverse effects Cyclosporine - pharmacokinetics Cyclosporins Diagnosis Europe - epidemiology Female Follow-Up Studies Glomerular filtration rate Graft Rejection - immunology Graft Rejection - prevention & control Health risk assessment Humans Hypertension Hypertension - diagnosis Hypertension - epidemiology Hypertension - etiology Immunosuppression Immunosuppressive agents Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Immunosuppressive Agents - pharmacokinetics Kidney transplantation Kidney Transplantation - adverse effects Kidney transplants Kidneys Longitudinal Studies Male Medicine Medicine & Public Health Nephrology Original Article Patients Pediatric research Pediatrics Prevalence Puberty Registries - statistics & numerical data Retrospective Studies Risk factors Sex Sex Factors Tacrolimus - administration & dosage Tacrolimus - adverse effects Tacrolimus - pharmacokinetics Time Factors Transplant Recipients - statistics & numerical data Transplantation Transplants & implants Urinary tract Urology What’s new in Hypertension |
title | Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T12%3A25%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sex%20and%20age%20as%20determinants%20for%20high%20blood%20pressure%20in%20pediatric%20renal%20transplant%20recipients:%20a%20longitudinal%20analysis%20of%20the%20CERTAIN%20Registry&rft.jtitle=Pediatric%20nephrology%20(Berlin,%20West)&rft.au=Sugianto,%20Rizky%20I.&rft.date=2020-03-01&rft.volume=35&rft.issue=3&rft.spage=415&rft.epage=426&rft.pages=415-426&rft.issn=0931-041X&rft.eissn=1432-198X&rft_id=info:doi/10.1007/s00467-019-04395-4&rft_dat=%3Cgale_proqu%3EA611677482%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2343579388&rft_id=info:pmid/31811541&rft_galeid=A611677482&rfr_iscdi=true |