The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter

The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter

The uncontrolled production of reactive oxygen species during photodynamic therapy (PDT) induces oxidative stress. The full potential of PDT is accomplished by delivery of a pi-extended porphyrin-type photosensitizer into mitochondria of tumor cells using a MITO-Porter, a mitochondrial targeting nan...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-01, Vol.56 (7), p.1145-1148
Hauptverfasser: Satrialdi, Munechika, Reina, Biju, Vasudevanpillai, Takano, Yuta, Harashima, Hideyoshi, Yamada, Yuma
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Chemistry
Chemistry, Multidisciplinary
Mitochondria
Nanotechnology devices
Optimization
Oxidation
Photodynamic therapy
Physical Sciences
Science & Technology
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Zusammenfassung:The uncontrolled production of reactive oxygen species during photodynamic therapy (PDT) induces oxidative stress. The full potential of PDT is accomplished by delivery of a pi-extended porphyrin-type photosensitizer into mitochondria of tumor cells using a MITO-Porter, a mitochondrial targeting nanodevice. This strategy can be implemented for innovative cancer therapy. The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc08563g