APPLICATION OF NANOCLUSTER IRON–MOLYBDENE POLYOXOMETALATES FOR CORRECTION OF EXPERIMENTAL POSTHEMORRHAGIC ANEMIA
The widespread occurrence of anemia and the presence of side-effects of existing iron-containing drugs require the search for new drugs. In an experiment on male rats of the Wistar strain, posthemorrhagic anemia is simulated by collecting blood from the tail vein in an amount of 1.5% of body weight....
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| Veröffentlicht in: | Nanotechnologies in Russia 2019-03, Vol.14 (3-4), p.159-164 |
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| container_title | Nanotechnologies in Russia |
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| creator | Ostroushko, A. A. Gette, I. F. Brilliant, S. A. Danilova, I. G. |
| description | The widespread occurrence of anemia and the presence of side-effects of existing iron-containing drugs require the search for new drugs. In an experiment on male rats of the Wistar strain, posthemorrhagic anemia is simulated by collecting blood from the tail vein in an amount of 1.5% of body weight. Intramuscular administration of iron–molybdenum polyoxometallates in an amount of 1.5 mg/kg to rats with anemia results in a faster restoration of the content of red blood cells and hemoglobin, the hematocrit value in the blood, the concentration of iron in the blood plasma, and the content of erythrocyte precursors in the bone marrow, which recover one to seven days earlier than the parameters measured in a control group of untreated animals. |
| doi_str_mv | 10.1134/S1995078019020101 |
| format | Article |
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| identifier | ISSN: 1995-0780 |
| ispartof | Nanotechnologies in Russia, 2019-03, Vol.14 (3-4), p.159-164 |
| issn | 1995-0780 1995-0799 |
| language | eng |
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| source | SpringerNature Journals |
| subjects | Anemia Blood plasma Body weight Bone marrow Chemistry and Materials Science Drugs Erythrocytes Hematocrit Hemoglobin Industrial and Production Engineering Iron Machines Manufacturing Materials Science Nanobiomedicine and Nanopharmaceuticals Nanoclusters Nanotechnology Polyoxometallates Processes Restoration Rodents |
| title | APPLICATION OF NANOCLUSTER IRON–MOLYBDENE POLYOXOMETALATES FOR CORRECTION OF EXPERIMENTAL POSTHEMORRHAGIC ANEMIA |
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