BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells
Blood–brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N -...
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| Veröffentlicht in: | Journal of natural medicines 2020, Vol.74 (1), p.212-218 |
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| creator | Yano, Mamiko Nakashima, Souichi Oda, Yoshimi Nakamura, Seikou Matsuda, Hisashi |
| description | Blood–brain barrier (BBB)-permeable components in the methanolic extract of
Nelumbo nucifera
flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from
N. nucifera
flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine,
N
-methylasimilobine, and pronuciferine, showed accelerative effects. Lirinidine,
N
-methylasimilobine, and an alkaloid-rich diethyl ether fraction at low concentrations increased the expression of mRNAs coding for TrkA, Vav3, and Rac1. In addition, good permeability of asimilobine and
N
-methylasimilobine was confirmed using an in vitro BBB model. Asimilobine and
N
-methylasimilobine are considered to be suitable as seed compounds of drugs for Alzheimer’s disease, because of their activity and BBB permeability. |
| doi_str_mv | 10.1007/s11418-019-01368-7 |
| format | Article |
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Nelumbo nucifera
flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from
N. nucifera
flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine,
N
-methylasimilobine, and pronuciferine, showed accelerative effects. Lirinidine,
N
-methylasimilobine, and an alkaloid-rich diethyl ether fraction at low concentrations increased the expression of mRNAs coding for TrkA, Vav3, and Rac1. In addition, good permeability of asimilobine and
N
-methylasimilobine was confirmed using an in vitro BBB model. Asimilobine and
N
-methylasimilobine are considered to be suitable as seed compounds of drugs for Alzheimer’s disease, because of their activity and BBB permeability.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-019-01368-7</identifier><identifier>PMID: 31707550</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Alkaloids ; Alkaloids - pharmacology ; Alzheimer Disease - drug therapy ; Alzheimer's disease ; Animals ; Aporphines - pharmacology ; Axonogenesis ; Biomedical and Life Sciences ; Biomedicine ; Blood-brain barrier ; Blood-Brain Barrier - drug effects ; Cell Line, Tumor ; Complementary & Alternative Medicine ; Flowers ; Flowers - chemistry ; Medicinal Chemistry ; Membrane permeability ; Methanol ; Nelumbo - chemistry ; Nelumbo nucifera ; Neural coding ; Neurites - metabolism ; Neurodegenerative diseases ; Neuronal Outgrowth - drug effects ; Original Paper ; PC12 Cells ; Permeability ; Pharmacology/Toxicology ; Pharmacy ; Phytochemicals ; Plant Extracts - pharmacology ; Plant Sciences ; Rac1 protein ; Rats ; Spiro Compounds - pharmacology ; TrkA protein</subject><ispartof>Journal of natural medicines, 2020, Vol.74 (1), p.212-218</ispartof><rights>The Japanese Society of Pharmacognosy 2019</rights><rights>2019© The Japanese Society of Pharmacognosy 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-9f2e309ad0b8707f3a60077b9c05d38b29ccb1a8701a817b5b75ab0808f49fcc3</citedby><cites>FETCH-LOGICAL-c399t-9f2e309ad0b8707f3a60077b9c05d38b29ccb1a8701a817b5b75ab0808f49fcc3</cites><orcidid>0000-0003-4217-065X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-019-01368-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-019-01368-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31707550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yano, Mamiko</creatorcontrib><creatorcontrib>Nakashima, Souichi</creatorcontrib><creatorcontrib>Oda, Yoshimi</creatorcontrib><creatorcontrib>Nakamura, Seikou</creatorcontrib><creatorcontrib>Matsuda, Hisashi</creatorcontrib><title>BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>Blood–brain barrier (BBB)-permeable components in the methanolic extract of
Nelumbo nucifera
flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from
N. nucifera
flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine,
N
-methylasimilobine, and pronuciferine, showed accelerative effects. Lirinidine,
N
-methylasimilobine, and an alkaloid-rich diethyl ether fraction at low concentrations increased the expression of mRNAs coding for TrkA, Vav3, and Rac1. In addition, good permeability of asimilobine and
N
-methylasimilobine was confirmed using an in vitro BBB model. Asimilobine and
N
-methylasimilobine are considered to be suitable as seed compounds of drugs for Alzheimer’s disease, because of their activity and BBB permeability.</description><subject>Alkaloids</subject><subject>Alkaloids - pharmacology</subject><subject>Alzheimer Disease - drug therapy</subject><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Aporphines - pharmacology</subject><subject>Axonogenesis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood-brain barrier</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Complementary & Alternative Medicine</subject><subject>Flowers</subject><subject>Flowers - chemistry</subject><subject>Medicinal Chemistry</subject><subject>Membrane permeability</subject><subject>Methanol</subject><subject>Nelumbo - chemistry</subject><subject>Nelumbo nucifera</subject><subject>Neural coding</subject><subject>Neurites - metabolism</subject><subject>Neurodegenerative diseases</subject><subject>Neuronal Outgrowth - drug effects</subject><subject>Original Paper</subject><subject>PC12 Cells</subject><subject>Permeability</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Phytochemicals</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Sciences</subject><subject>Rac1 protein</subject><subject>Rats</subject><subject>Spiro Compounds - pharmacology</subject><subject>TrkA protein</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v3CAQhlGVqvlo_0APEVLOJOCx13DsrvolRW0P7RkBO-w68RoH7K721p_eaTdpbj0AA_O-76CHsbdKXisp25uiVK20kMrQgoUW7Qt2pvRCCVkZOKEaaimgruGUnZdyJ2VdAahX7BRUK9umkWfs13K5FCPmHTrfI3djyuO2G1BMh5Gu_b3rU7cuvBv4F-znnU98mEMXMTse-7THXPi-m7bchYA9vU7dT-QYI4ap8DTwAefcTcjTPG1y2pOSor6thKo4Gfrymr2Mri_45vG8YD8-vP---iRuv378vHp3KwIYMwkTKwRp3Fp6TX-P4BaEoPUmyGYN2lcmBK8c9WhTrW982zgvtdSxNjEEuGBXx9wxp4cZy2Tv0pwHGmkrqKHSSoMmVXVUhZxKyRjtmLudywerpP0D3R6hW4Ju_0K3LZkuH6Nnv8P1P8sTZRLAUVCoNWwwP8_-T-xvSZ-N1Q</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Yano, Mamiko</creator><creator>Nakashima, Souichi</creator><creator>Oda, Yoshimi</creator><creator>Nakamura, Seikou</creator><creator>Matsuda, Hisashi</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0003-4217-065X</orcidid></search><sort><creationdate>2020</creationdate><title>BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells</title><author>Yano, Mamiko ; Nakashima, Souichi ; Oda, Yoshimi ; Nakamura, Seikou ; Matsuda, Hisashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-9f2e309ad0b8707f3a60077b9c05d38b29ccb1a8701a817b5b75ab0808f49fcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alkaloids</topic><topic>Alkaloids - pharmacology</topic><topic>Alzheimer Disease - drug therapy</topic><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Aporphines - pharmacology</topic><topic>Axonogenesis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood-brain barrier</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Complementary & Alternative Medicine</topic><topic>Flowers</topic><topic>Flowers - chemistry</topic><topic>Medicinal Chemistry</topic><topic>Membrane permeability</topic><topic>Methanol</topic><topic>Nelumbo - chemistry</topic><topic>Nelumbo nucifera</topic><topic>Neural coding</topic><topic>Neurites - metabolism</topic><topic>Neurodegenerative diseases</topic><topic>Neuronal Outgrowth - drug effects</topic><topic>Original Paper</topic><topic>PC12 Cells</topic><topic>Permeability</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Phytochemicals</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Sciences</topic><topic>Rac1 protein</topic><topic>Rats</topic><topic>Spiro Compounds - pharmacology</topic><topic>TrkA protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yano, Mamiko</creatorcontrib><creatorcontrib>Nakashima, Souichi</creatorcontrib><creatorcontrib>Oda, Yoshimi</creatorcontrib><creatorcontrib>Nakamura, Seikou</creatorcontrib><creatorcontrib>Matsuda, Hisashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yano, Mamiko</au><au>Nakashima, Souichi</au><au>Oda, Yoshimi</au><au>Nakamura, Seikou</au><au>Matsuda, Hisashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2020</date><risdate>2020</risdate><volume>74</volume><issue>1</issue><spage>212</spage><epage>218</epage><pages>212-218</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>Blood–brain barrier (BBB)-permeable components in the methanolic extract of
Nelumbo nucifera
flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from
N. nucifera
flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine,
N
-methylasimilobine, and pronuciferine, showed accelerative effects. Lirinidine,
N
-methylasimilobine, and an alkaloid-rich diethyl ether fraction at low concentrations increased the expression of mRNAs coding for TrkA, Vav3, and Rac1. In addition, good permeability of asimilobine and
N
-methylasimilobine was confirmed using an in vitro BBB model. Asimilobine and
N
-methylasimilobine are considered to be suitable as seed compounds of drugs for Alzheimer’s disease, because of their activity and BBB permeability.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>31707550</pmid><doi>10.1007/s11418-019-01368-7</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4217-065X</orcidid></addata></record> |
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| subjects | Alkaloids Alkaloids - pharmacology Alzheimer Disease - drug therapy Alzheimer's disease Animals Aporphines - pharmacology Axonogenesis Biomedical and Life Sciences Biomedicine Blood-brain barrier Blood-Brain Barrier - drug effects Cell Line, Tumor Complementary & Alternative Medicine Flowers Flowers - chemistry Medicinal Chemistry Membrane permeability Methanol Nelumbo - chemistry Nelumbo nucifera Neural coding Neurites - metabolism Neurodegenerative diseases Neuronal Outgrowth - drug effects Original Paper PC12 Cells Permeability Pharmacology/Toxicology Pharmacy Phytochemicals Plant Extracts - pharmacology Plant Sciences Rac1 protein Rats Spiro Compounds - pharmacology TrkA protein |
| title | BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells |
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