Cardiovascular Magnetic Resonance Relaxometry in Early Detection of Anthracycline Cardiotoxicity
Purpose of the Review To provide an overview of the published data on the value of cardiovascular magnetic resonance (CMR) based T1 and T2 and extracellular volume (ECV) fraction quantification to identify myocardial abnormalities related to anthracycline treatment in patients with cancer. Recent Fi...
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| Veröffentlicht in: | Current cardiovascular imaging reports 2020, Vol.13 (1), Article 2 |
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| creator | Urzua Fresno, Camila Shalmon, Tamar Calvillo Argüelles, Oscar Wintersperger, Bernd J. Thavendiranathan, Paaladinesh |
| description | Purpose of the Review
To provide an overview of the published data on the value of cardiovascular magnetic resonance (CMR) based T1 and T2 and extracellular volume (ECV) fraction quantification to identify myocardial abnormalities related to anthracycline treatment in patients with cancer.
Recent Findings
In animal models of anthracycline cardiotoxicity, elevations in myocardial T1 and T2 values appear to occur early during treatment followed by ventricular remodeling, persistent elevation in T1, and increase in ECV. These findings suggest early myocardial inflammation/edema followed by myocardial fibrosis and ventricular dysfunction. Similarly in patients receiving cancer therapy, T1 and ECV values increase early after anthracycline therapy. The value of T2 mapping in this setting has not been established. Likewise, adult cancer survivors with or without LV dysfunction have increased ECV values which may be associated with worse diastolic parameters. The value of ECV to identify subclinical cardiomyopathy in pediatric cancer survivors remains controversial.
Summary
Quantitative CMR tissue characterization techniques may have a unique role in identifying the pathophysiology of anthracycline-induced cardiomyopathy and for early detection of myocardial injury. In cancer survivors, these techniques have a potential role in identifying early and subclinical myocardial injury. However, the overall literature on quantitative CMR tissue characterization techniques to detect anthracycline cardiotoxicity is limited. |
| doi_str_mv | 10.1007/s12410-019-9524-2 |
| format | Article |
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To provide an overview of the published data on the value of cardiovascular magnetic resonance (CMR) based T1 and T2 and extracellular volume (ECV) fraction quantification to identify myocardial abnormalities related to anthracycline treatment in patients with cancer.
Recent Findings
In animal models of anthracycline cardiotoxicity, elevations in myocardial T1 and T2 values appear to occur early during treatment followed by ventricular remodeling, persistent elevation in T1, and increase in ECV. These findings suggest early myocardial inflammation/edema followed by myocardial fibrosis and ventricular dysfunction. Similarly in patients receiving cancer therapy, T1 and ECV values increase early after anthracycline therapy. The value of T2 mapping in this setting has not been established. Likewise, adult cancer survivors with or without LV dysfunction have increased ECV values which may be associated with worse diastolic parameters. The value of ECV to identify subclinical cardiomyopathy in pediatric cancer survivors remains controversial.
Summary
Quantitative CMR tissue characterization techniques may have a unique role in identifying the pathophysiology of anthracycline-induced cardiomyopathy and for early detection of myocardial injury. In cancer survivors, these techniques have a potential role in identifying early and subclinical myocardial injury. However, the overall literature on quantitative CMR tissue characterization techniques to detect anthracycline cardiotoxicity is limited.</description><identifier>ISSN: 1941-9066</identifier><identifier>EISSN: 1941-9074</identifier><identifier>DOI: 10.1007/s12410-019-9524-2</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abnormalities ; Cancer ; Cardio-Oncology (J Mitchell ; Cardiology ; Cardiomyopathy ; Diagnostic Radiology ; Edema ; Fibrosis ; Imaging ; Interventional Radiology ; Magnetic resonance ; Mapping ; Medicine ; Medicine & Public Health ; Nuclear Medicine ; Parameter identification ; Radiology ; Section Editor ; Survival ; Therapy ; Topical Collection on Cardio-Oncology ; Ultrasound</subject><ispartof>Current cardiovascular imaging reports, 2020, Vol.13 (1), Article 2</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>2020© Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-1c495fa6b92b800638d58afc8a3148fc6cdad3612380320242e47d73aef3f1d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12410-019-9524-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12410-019-9524-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Urzua Fresno, Camila</creatorcontrib><creatorcontrib>Shalmon, Tamar</creatorcontrib><creatorcontrib>Calvillo Argüelles, Oscar</creatorcontrib><creatorcontrib>Wintersperger, Bernd J.</creatorcontrib><creatorcontrib>Thavendiranathan, Paaladinesh</creatorcontrib><title>Cardiovascular Magnetic Resonance Relaxometry in Early Detection of Anthracycline Cardiotoxicity</title><title>Current cardiovascular imaging reports</title><addtitle>Curr Cardiovasc Imaging Rep</addtitle><description>Purpose of the Review
To provide an overview of the published data on the value of cardiovascular magnetic resonance (CMR) based T1 and T2 and extracellular volume (ECV) fraction quantification to identify myocardial abnormalities related to anthracycline treatment in patients with cancer.
Recent Findings
In animal models of anthracycline cardiotoxicity, elevations in myocardial T1 and T2 values appear to occur early during treatment followed by ventricular remodeling, persistent elevation in T1, and increase in ECV. These findings suggest early myocardial inflammation/edema followed by myocardial fibrosis and ventricular dysfunction. Similarly in patients receiving cancer therapy, T1 and ECV values increase early after anthracycline therapy. The value of T2 mapping in this setting has not been established. Likewise, adult cancer survivors with or without LV dysfunction have increased ECV values which may be associated with worse diastolic parameters. The value of ECV to identify subclinical cardiomyopathy in pediatric cancer survivors remains controversial.
Summary
Quantitative CMR tissue characterization techniques may have a unique role in identifying the pathophysiology of anthracycline-induced cardiomyopathy and for early detection of myocardial injury. In cancer survivors, these techniques have a potential role in identifying early and subclinical myocardial injury. However, the overall literature on quantitative CMR tissue characterization techniques to detect anthracycline cardiotoxicity is limited.</description><subject>Abnormalities</subject><subject>Cancer</subject><subject>Cardio-Oncology (J Mitchell</subject><subject>Cardiology</subject><subject>Cardiomyopathy</subject><subject>Diagnostic Radiology</subject><subject>Edema</subject><subject>Fibrosis</subject><subject>Imaging</subject><subject>Interventional Radiology</subject><subject>Magnetic resonance</subject><subject>Mapping</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nuclear Medicine</subject><subject>Parameter identification</subject><subject>Radiology</subject><subject>Section Editor</subject><subject>Survival</subject><subject>Therapy</subject><subject>Topical Collection on Cardio-Oncology</subject><subject>Ultrasound</subject><issn>1941-9066</issn><issn>1941-9074</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKAzEUhoMoWKsP4C7gejS3zmSWpdYLVATRdTzNJDVlmtQklc7bO2VEV67Ov_gvhw-hS0quKSHVTaJMUFIQWhf1hImCHaERrQUtalKJ419dlqfoLKU1ISVnEzZC7zOIjQtfkPSuhYifYOVNdhq_mBQ8eG161cI-bEyOHXYezyG2Hb412ejsgsfB4qnPHxF0p1vnDR4ac9g77XJ3jk4stMlc_Nwxerubv84eisXz_eNsuig0K2UuqBb1xEK5rNlSHr6TzUSC1RI4FdLqUjfQ8JIyLglnhAlmRNVUHIzlljacj9HV0LuN4XNnUlbrsIu-n1SMC84qSWrau-jg0jGkFI1V2-g2EDtFiTqAVANI1YNUB5B9eIzYkEm9169M_Gv-P_QNFAF2uQ</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Urzua Fresno, Camila</creator><creator>Shalmon, Tamar</creator><creator>Calvillo Argüelles, Oscar</creator><creator>Wintersperger, Bernd J.</creator><creator>Thavendiranathan, Paaladinesh</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2020</creationdate><title>Cardiovascular Magnetic Resonance Relaxometry in Early Detection of Anthracycline Cardiotoxicity</title><author>Urzua Fresno, Camila ; Shalmon, Tamar ; Calvillo Argüelles, Oscar ; Wintersperger, Bernd J. ; Thavendiranathan, Paaladinesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-1c495fa6b92b800638d58afc8a3148fc6cdad3612380320242e47d73aef3f1d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abnormalities</topic><topic>Cancer</topic><topic>Cardio-Oncology (J Mitchell</topic><topic>Cardiology</topic><topic>Cardiomyopathy</topic><topic>Diagnostic Radiology</topic><topic>Edema</topic><topic>Fibrosis</topic><topic>Imaging</topic><topic>Interventional Radiology</topic><topic>Magnetic resonance</topic><topic>Mapping</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nuclear Medicine</topic><topic>Parameter identification</topic><topic>Radiology</topic><topic>Section Editor</topic><topic>Survival</topic><topic>Therapy</topic><topic>Topical Collection on Cardio-Oncology</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Urzua Fresno, Camila</creatorcontrib><creatorcontrib>Shalmon, Tamar</creatorcontrib><creatorcontrib>Calvillo Argüelles, Oscar</creatorcontrib><creatorcontrib>Wintersperger, Bernd J.</creatorcontrib><creatorcontrib>Thavendiranathan, Paaladinesh</creatorcontrib><collection>CrossRef</collection><jtitle>Current cardiovascular imaging reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Urzua Fresno, Camila</au><au>Shalmon, Tamar</au><au>Calvillo Argüelles, Oscar</au><au>Wintersperger, Bernd J.</au><au>Thavendiranathan, Paaladinesh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular Magnetic Resonance Relaxometry in Early Detection of Anthracycline Cardiotoxicity</atitle><jtitle>Current cardiovascular imaging reports</jtitle><stitle>Curr Cardiovasc Imaging Rep</stitle><date>2020</date><risdate>2020</risdate><volume>13</volume><issue>1</issue><artnum>2</artnum><issn>1941-9066</issn><eissn>1941-9074</eissn><abstract>Purpose of the Review
To provide an overview of the published data on the value of cardiovascular magnetic resonance (CMR) based T1 and T2 and extracellular volume (ECV) fraction quantification to identify myocardial abnormalities related to anthracycline treatment in patients with cancer.
Recent Findings
In animal models of anthracycline cardiotoxicity, elevations in myocardial T1 and T2 values appear to occur early during treatment followed by ventricular remodeling, persistent elevation in T1, and increase in ECV. These findings suggest early myocardial inflammation/edema followed by myocardial fibrosis and ventricular dysfunction. Similarly in patients receiving cancer therapy, T1 and ECV values increase early after anthracycline therapy. The value of T2 mapping in this setting has not been established. Likewise, adult cancer survivors with or without LV dysfunction have increased ECV values which may be associated with worse diastolic parameters. The value of ECV to identify subclinical cardiomyopathy in pediatric cancer survivors remains controversial.
Summary
Quantitative CMR tissue characterization techniques may have a unique role in identifying the pathophysiology of anthracycline-induced cardiomyopathy and for early detection of myocardial injury. In cancer survivors, these techniques have a potential role in identifying early and subclinical myocardial injury. However, the overall literature on quantitative CMR tissue characterization techniques to detect anthracycline cardiotoxicity is limited.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s12410-019-9524-2</doi></addata></record> |
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| subjects | Abnormalities Cancer Cardio-Oncology (J Mitchell Cardiology Cardiomyopathy Diagnostic Radiology Edema Fibrosis Imaging Interventional Radiology Magnetic resonance Mapping Medicine Medicine & Public Health Nuclear Medicine Parameter identification Radiology Section Editor Survival Therapy Topical Collection on Cardio-Oncology Ultrasound |
| title | Cardiovascular Magnetic Resonance Relaxometry in Early Detection of Anthracycline Cardiotoxicity |
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