Performance Evaluation of a Novel Preclinical Micro-CT System In Vitro and In Vivo
Purpose With the advent of innovation in the preclinical studies, micro-CT provides optimized resolution by high-power X-ray output tube and flat-panel detector with ultra-short scanning time. The aim of this study was to evaluate the performance of a novel preclinical micro-CT with different parame...
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| Veröffentlicht in: | Journal of medical and biological engineering 2020-02, Vol.40 (1), p.24-34 |
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| creator | Lo, Yi-Wen Ke, Chien-Chih Lee, Jhih-Shain Chiu, Hsien-Chih Lu, Cheng-Hsu Chen, Sih-Yu Yang, Wen-Chieh Hu, Ming-Chin Yang, Bang-Hung Huang, Wen-Sheng Liu, Ren-Shyan |
| description | Purpose
With the advent of innovation in the preclinical studies, micro-CT provides optimized resolution by high-power X-ray output tube and flat-panel detector with ultra-short scanning time. The aim of this study was to evaluate the performance of a novel preclinical micro-CT with different parameters and protocols.
Methods
Imaging quality was evaluated by micro-CT HA and wire phantom. The high power output X-ray tube provides tube voltage from 40 to 90 kV with tube current, 10 to 800 μA. The detector with 1536 × 1944 pixels was implemented by three different binning modes (1 × 1, 2 × 2 and 4 × 4). The GPU-based reconstruction was applied with Feldkamp’s algorithm. The maximum reconstruction volume was 1944 × 1944 × 4536 per scan. The phantom images were acquired by four modes with pixel sizes of 44.9, 22.5,15 and 9 μm. In the animal study, ovariectomy mice were imaged followed by analysis of bone mineral density (BMD) and BV/TV ratio (bone volume/total bone volume).
Results
Linearity (R
2
) measured in all imaging settings were > 0.9 and was 0.99962 at setting of 0.2 mm Cu filter, 90 kV tube voltage and 556 μA tube current. The spatial resolution as measured by full width half-maximum amplitude (FWHM) was 24 µm in the mode ultra-high resolution. The bone analysis results show the operated cohort has high significant (p |
| doi_str_mv | 10.1007/s40846-019-00487-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2343276044</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2343276044</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-4e2a4a4af65bca6ddd559d7c79bfe17f4c04abc984909c87dbd5ef72b876f9fc3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMoWGr_gKeA52iym4_NUUrVQtWi1WvIZhPZsk1qslvovze6gjdnDsMw7zszPABcEnxNMBY3ieKKcoSJRBjTSiB-AiYFkRJRwcQpmBCO80hW7BzMUtriHKXknFQT8LK20YW4095YuDjobtB9GzwMDmr4FA62g-toTdf61ugOPrYmBjTfwNdj6u0OLj18b_sYoPbN2BzCBThzukt29lun4O1usZk_oNXz_XJ-u0KmZLxH1Baa5nSc1UbzpmkYk40wQtbOEuGowVTXRlZUYmkq0dQNs04UdSW4k86UU3A17t3H8DnY1KttGKLPJ1VR0rIQHFOaVcWoyo-nFK1T-9judDwqgtU3PjXiUxmf-sGneDaVoyllsf-w8W_1P64vwDFyew</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2343276044</pqid></control><display><type>article</type><title>Performance Evaluation of a Novel Preclinical Micro-CT System In Vitro and In Vivo</title><source>SpringerLink Journals</source><creator>Lo, Yi-Wen ; Ke, Chien-Chih ; Lee, Jhih-Shain ; Chiu, Hsien-Chih ; Lu, Cheng-Hsu ; Chen, Sih-Yu ; Yang, Wen-Chieh ; Hu, Ming-Chin ; Yang, Bang-Hung ; Huang, Wen-Sheng ; Liu, Ren-Shyan</creator><creatorcontrib>Lo, Yi-Wen ; Ke, Chien-Chih ; Lee, Jhih-Shain ; Chiu, Hsien-Chih ; Lu, Cheng-Hsu ; Chen, Sih-Yu ; Yang, Wen-Chieh ; Hu, Ming-Chin ; Yang, Bang-Hung ; Huang, Wen-Sheng ; Liu, Ren-Shyan</creatorcontrib><description>Purpose
With the advent of innovation in the preclinical studies, micro-CT provides optimized resolution by high-power X-ray output tube and flat-panel detector with ultra-short scanning time. The aim of this study was to evaluate the performance of a novel preclinical micro-CT with different parameters and protocols.
Methods
Imaging quality was evaluated by micro-CT HA and wire phantom. The high power output X-ray tube provides tube voltage from 40 to 90 kV with tube current, 10 to 800 μA. The detector with 1536 × 1944 pixels was implemented by three different binning modes (1 × 1, 2 × 2 and 4 × 4). The GPU-based reconstruction was applied with Feldkamp’s algorithm. The maximum reconstruction volume was 1944 × 1944 × 4536 per scan. The phantom images were acquired by four modes with pixel sizes of 44.9, 22.5,15 and 9 μm. In the animal study, ovariectomy mice were imaged followed by analysis of bone mineral density (BMD) and BV/TV ratio (bone volume/total bone volume).
Results
Linearity (R
2
) measured in all imaging settings were > 0.9 and was 0.99962 at setting of 0.2 mm Cu filter, 90 kV tube voltage and 556 μA tube current. The spatial resolution as measured by full width half-maximum amplitude (FWHM) was 24 µm in the mode ultra-high resolution. The bone analysis results show the operated cohort has high significant (p < 0.05), whereas the control cohort revealed insignificant either in the BMD.
Conclusion
In summary, this novel micro-CT system demonstrated the flexible capability and high spatial resolution with ultra-short acquisition time, and a feasible quantitative BMD software.</description><identifier>ISSN: 1609-0985</identifier><identifier>EISSN: 2199-4757</identifier><identifier>DOI: 10.1007/s40846-019-00487-6</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Algorithms ; Biomedical Engineering and Bioengineering ; Bone imaging ; Bone mineral density ; Cell Biology ; Computed tomography ; Electric potential ; Engineering ; High resolution ; Image acquisition ; Image reconstruction ; Imaging ; In vivo methods and tests ; Linearity ; Original Article ; Ovariectomy ; Performance evaluation ; Pixels ; Radiology ; Spatial discrimination ; Spatial resolution ; Voltage ; X ray tubes</subject><ispartof>Journal of medical and biological engineering, 2020-02, Vol.40 (1), p.24-34</ispartof><rights>Taiwanese Society of Biomedical Engineering 2019</rights><rights>2019© Taiwanese Society of Biomedical Engineering 2019</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-4e2a4a4af65bca6ddd559d7c79bfe17f4c04abc984909c87dbd5ef72b876f9fc3</citedby><cites>FETCH-LOGICAL-c356t-4e2a4a4af65bca6ddd559d7c79bfe17f4c04abc984909c87dbd5ef72b876f9fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40846-019-00487-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40846-019-00487-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Lo, Yi-Wen</creatorcontrib><creatorcontrib>Ke, Chien-Chih</creatorcontrib><creatorcontrib>Lee, Jhih-Shain</creatorcontrib><creatorcontrib>Chiu, Hsien-Chih</creatorcontrib><creatorcontrib>Lu, Cheng-Hsu</creatorcontrib><creatorcontrib>Chen, Sih-Yu</creatorcontrib><creatorcontrib>Yang, Wen-Chieh</creatorcontrib><creatorcontrib>Hu, Ming-Chin</creatorcontrib><creatorcontrib>Yang, Bang-Hung</creatorcontrib><creatorcontrib>Huang, Wen-Sheng</creatorcontrib><creatorcontrib>Liu, Ren-Shyan</creatorcontrib><title>Performance Evaluation of a Novel Preclinical Micro-CT System In Vitro and In Vivo</title><title>Journal of medical and biological engineering</title><addtitle>J. Med. Biol. Eng</addtitle><description>Purpose
With the advent of innovation in the preclinical studies, micro-CT provides optimized resolution by high-power X-ray output tube and flat-panel detector with ultra-short scanning time. The aim of this study was to evaluate the performance of a novel preclinical micro-CT with different parameters and protocols.
Methods
Imaging quality was evaluated by micro-CT HA and wire phantom. The high power output X-ray tube provides tube voltage from 40 to 90 kV with tube current, 10 to 800 μA. The detector with 1536 × 1944 pixels was implemented by three different binning modes (1 × 1, 2 × 2 and 4 × 4). The GPU-based reconstruction was applied with Feldkamp’s algorithm. The maximum reconstruction volume was 1944 × 1944 × 4536 per scan. The phantom images were acquired by four modes with pixel sizes of 44.9, 22.5,15 and 9 μm. In the animal study, ovariectomy mice were imaged followed by analysis of bone mineral density (BMD) and BV/TV ratio (bone volume/total bone volume).
Results
Linearity (R
2
) measured in all imaging settings were > 0.9 and was 0.99962 at setting of 0.2 mm Cu filter, 90 kV tube voltage and 556 μA tube current. The spatial resolution as measured by full width half-maximum amplitude (FWHM) was 24 µm in the mode ultra-high resolution. The bone analysis results show the operated cohort has high significant (p < 0.05), whereas the control cohort revealed insignificant either in the BMD.
Conclusion
In summary, this novel micro-CT system demonstrated the flexible capability and high spatial resolution with ultra-short acquisition time, and a feasible quantitative BMD software.</description><subject>Algorithms</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Bone imaging</subject><subject>Bone mineral density</subject><subject>Cell Biology</subject><subject>Computed tomography</subject><subject>Electric potential</subject><subject>Engineering</subject><subject>High resolution</subject><subject>Image acquisition</subject><subject>Image reconstruction</subject><subject>Imaging</subject><subject>In vivo methods and tests</subject><subject>Linearity</subject><subject>Original Article</subject><subject>Ovariectomy</subject><subject>Performance evaluation</subject><subject>Pixels</subject><subject>Radiology</subject><subject>Spatial discrimination</subject><subject>Spatial resolution</subject><subject>Voltage</subject><subject>X ray tubes</subject><issn>1609-0985</issn><issn>2199-4757</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoWGr_gKeA52iym4_NUUrVQtWi1WvIZhPZsk1qslvovze6gjdnDsMw7zszPABcEnxNMBY3ieKKcoSJRBjTSiB-AiYFkRJRwcQpmBCO80hW7BzMUtriHKXknFQT8LK20YW4095YuDjobtB9GzwMDmr4FA62g-toTdf61ugOPrYmBjTfwNdj6u0OLj18b_sYoPbN2BzCBThzukt29lun4O1usZk_oNXz_XJ-u0KmZLxH1Baa5nSc1UbzpmkYk40wQtbOEuGowVTXRlZUYmkq0dQNs04UdSW4k86UU3A17t3H8DnY1KttGKLPJ1VR0rIQHFOaVcWoyo-nFK1T-9judDwqgtU3PjXiUxmf-sGneDaVoyllsf-w8W_1P64vwDFyew</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Lo, Yi-Wen</creator><creator>Ke, Chien-Chih</creator><creator>Lee, Jhih-Shain</creator><creator>Chiu, Hsien-Chih</creator><creator>Lu, Cheng-Hsu</creator><creator>Chen, Sih-Yu</creator><creator>Yang, Wen-Chieh</creator><creator>Hu, Ming-Chin</creator><creator>Yang, Bang-Hung</creator><creator>Huang, Wen-Sheng</creator><creator>Liu, Ren-Shyan</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>20200201</creationdate><title>Performance Evaluation of a Novel Preclinical Micro-CT System In Vitro and In Vivo</title><author>Lo, Yi-Wen ; Ke, Chien-Chih ; Lee, Jhih-Shain ; Chiu, Hsien-Chih ; Lu, Cheng-Hsu ; Chen, Sih-Yu ; Yang, Wen-Chieh ; Hu, Ming-Chin ; Yang, Bang-Hung ; Huang, Wen-Sheng ; Liu, Ren-Shyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-4e2a4a4af65bca6ddd559d7c79bfe17f4c04abc984909c87dbd5ef72b876f9fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Algorithms</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Bone imaging</topic><topic>Bone mineral density</topic><topic>Cell Biology</topic><topic>Computed tomography</topic><topic>Electric potential</topic><topic>Engineering</topic><topic>High resolution</topic><topic>Image acquisition</topic><topic>Image reconstruction</topic><topic>Imaging</topic><topic>In vivo methods and tests</topic><topic>Linearity</topic><topic>Original Article</topic><topic>Ovariectomy</topic><topic>Performance evaluation</topic><topic>Pixels</topic><topic>Radiology</topic><topic>Spatial discrimination</topic><topic>Spatial resolution</topic><topic>Voltage</topic><topic>X ray tubes</topic><toplevel>online_resources</toplevel><creatorcontrib>Lo, Yi-Wen</creatorcontrib><creatorcontrib>Ke, Chien-Chih</creatorcontrib><creatorcontrib>Lee, Jhih-Shain</creatorcontrib><creatorcontrib>Chiu, Hsien-Chih</creatorcontrib><creatorcontrib>Lu, Cheng-Hsu</creatorcontrib><creatorcontrib>Chen, Sih-Yu</creatorcontrib><creatorcontrib>Yang, Wen-Chieh</creatorcontrib><creatorcontrib>Hu, Ming-Chin</creatorcontrib><creatorcontrib>Yang, Bang-Hung</creatorcontrib><creatorcontrib>Huang, Wen-Sheng</creatorcontrib><creatorcontrib>Liu, Ren-Shyan</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of medical and biological engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lo, Yi-Wen</au><au>Ke, Chien-Chih</au><au>Lee, Jhih-Shain</au><au>Chiu, Hsien-Chih</au><au>Lu, Cheng-Hsu</au><au>Chen, Sih-Yu</au><au>Yang, Wen-Chieh</au><au>Hu, Ming-Chin</au><au>Yang, Bang-Hung</au><au>Huang, Wen-Sheng</au><au>Liu, Ren-Shyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Performance Evaluation of a Novel Preclinical Micro-CT System In Vitro and In Vivo</atitle><jtitle>Journal of medical and biological engineering</jtitle><stitle>J. Med. Biol. Eng</stitle><date>2020-02-01</date><risdate>2020</risdate><volume>40</volume><issue>1</issue><spage>24</spage><epage>34</epage><pages>24-34</pages><issn>1609-0985</issn><eissn>2199-4757</eissn><abstract>Purpose
With the advent of innovation in the preclinical studies, micro-CT provides optimized resolution by high-power X-ray output tube and flat-panel detector with ultra-short scanning time. The aim of this study was to evaluate the performance of a novel preclinical micro-CT with different parameters and protocols.
Methods
Imaging quality was evaluated by micro-CT HA and wire phantom. The high power output X-ray tube provides tube voltage from 40 to 90 kV with tube current, 10 to 800 μA. The detector with 1536 × 1944 pixels was implemented by three different binning modes (1 × 1, 2 × 2 and 4 × 4). The GPU-based reconstruction was applied with Feldkamp’s algorithm. The maximum reconstruction volume was 1944 × 1944 × 4536 per scan. The phantom images were acquired by four modes with pixel sizes of 44.9, 22.5,15 and 9 μm. In the animal study, ovariectomy mice were imaged followed by analysis of bone mineral density (BMD) and BV/TV ratio (bone volume/total bone volume).
Results
Linearity (R
2
) measured in all imaging settings were > 0.9 and was 0.99962 at setting of 0.2 mm Cu filter, 90 kV tube voltage and 556 μA tube current. The spatial resolution as measured by full width half-maximum amplitude (FWHM) was 24 µm in the mode ultra-high resolution. The bone analysis results show the operated cohort has high significant (p < 0.05), whereas the control cohort revealed insignificant either in the BMD.
Conclusion
In summary, this novel micro-CT system demonstrated the flexible capability and high spatial resolution with ultra-short acquisition time, and a feasible quantitative BMD software.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s40846-019-00487-6</doi><tpages>11</tpages></addata></record> |
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| subjects | Algorithms Biomedical Engineering and Bioengineering Bone imaging Bone mineral density Cell Biology Computed tomography Electric potential Engineering High resolution Image acquisition Image reconstruction Imaging In vivo methods and tests Linearity Original Article Ovariectomy Performance evaluation Pixels Radiology Spatial discrimination Spatial resolution Voltage X ray tubes |
| title | Performance Evaluation of a Novel Preclinical Micro-CT System In Vitro and In Vivo |
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