Genetic Variations in Nrf2-Keap1 Complex: A Step towards Understanding Cancer Resistance in Blind Mole Rats Cytotypes

—The Nrf2-Keap1 regulation system plays a crucial role in cytoprotection against electrophilic/oxidative stress. Previous studies have identified missense mutations in Nrf2 / Keap1 complex which abolish its activity. The amino acid corresponding to codon 212 in Keapl’s IVR domain is conserved as tyr...

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Veröffentlicht in:	Biology bulletin of the Russian Academy of Sciences 2019-11, Vol.46 (6), p.547-554
Hauptverfasser:	Dilara Fatma Akın-Balı, Teoman Kankılıç
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Biochemistry Biomedical and Life Sciences Cancer Cell Biology Ecology Genetic diversity Genetics Hypoxia Life Sciences Missense mutation Oxidative stress Species Tyrosine Zoology
Online-Zugang:	Volltext
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