GLS2 is protumorigenic in breast cancers

Many types of cancers have a well-established dependence on glutamine metabolism to support survival and growth, a process linked to glutaminase 1 (GLS) isoforms. Conversely, GLS2 variants often have tumor-suppressing activity. Triple-negative (TN) breast cancer (testing negative for estrogen, proge...

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Veröffentlicht in:	Oncogene 2020-01, Vol.39 (3), p.690-702
Hauptverfasser:	Dias, Marilia M., Adamoski, Douglas, dos Reis, Larissa M., Ascenção, Carolline F. R., de Oliveira, Krishina R. S., Mafra, Ana Carolina Paschoalini, da Silva Bastos, Alliny Cristiny, Quintero, Melissa, de G. Cassago, Carolina, Ferreira, Igor M., Fidelis, Carlos H. V., Rocco, Silvana A., Bajgelman, Marcio Chaim, Stine, Zachary, Berindan-Neagoe, Ioana, Calin, George A., Ambrosio, Andre Luis Berteli, Dias, Sandra Martha Gomes
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 13/51 13/89 13/95 14/19 14/34 14/63 38/44 38/70 38/77 38/91 42/109 631/67/1347 631/67/322 631/80/83 64/60 Acetanilide Adult Aged Aged, 80 and over Apoptosis Benzeneacetamides - pharmacology Benzeneacetamides - therapeutic use Breast - pathology Breast - surgery Breast cancer Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - therapy Carcinogenesis - pathology Cell adhesion & migration Cell Biology Cell growth Cell Line, Tumor Cell migration Cell proliferation Clinical trials Disease-Free Survival Drug resistance ErbB-2 protein Female Gene Knockdown Techniques Glutaminase Glutaminase - antagonists & inhibitors Glutaminase - metabolism Glutamine Hormones, Sex Human Genetics Humans Internal Medicine Isoforms Lung Neoplasms - secondary Medical prognosis Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Middle Aged Mitochondria Oncology Phenotypes Physiological aspects Progesterone Prognosis Sulfides Sulfides - pharmacology Sulfides - therapeutic use Therapeutic applications Thiadiazoles - pharmacology Thiadiazoles - therapeutic use Tumor suppressor genes Vimentin
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