Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles

We demonstrate amyloid fibril (AF) decomposition induced by NIR-active upconversion nanoparticles complexed with photosensitisers. The process is triggered by upconversion, which initiates a photochemical reaction cascade that culminates in the generation of the highly reactive singlet-oxygen produc...

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Veröffentlicht in:	Photochemical & photobiological sciences 2020-01, Vol.19 (1), p.29-33
Hauptverfasser:	Harada, Takunori, Matsuzaki, Hiraku, Oyama, Ryohei, Takeuchi, Takuma, Takei, Tomoaki, Ninomiya, Taisuke, Takami, Kouta, Inoue, Takanori, Nishiguchi, Hiroyasu, Hifumi, Emi, Shinto, Hiroyuki, Takahashi, Hiromi, Umemura, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - antagonists & inhibitors Amyloid - metabolism Biochemistry Biomaterials Chemistry Communication Decomposition Fibrils Humans Infrared Rays Nanoparticles Nanoparticles - chemistry Photochemical reactions Photochemicals Photosensitizing Agents - pharmacology Physical Chemistry Plant Sciences Superstructures Upconversion
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