Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles
We demonstrate amyloid fibril (AF) decomposition induced by NIR-active upconversion nanoparticles complexed with photosensitisers. The process is triggered by upconversion, which initiates a photochemical reaction cascade that culminates in the generation of the highly reactive singlet-oxygen produc...
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| Veröffentlicht in: | Photochemical & photobiological sciences 2020-01, Vol.19 (1), p.29-33 |
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| container_title | Photochemical & photobiological sciences |
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| creator | Harada, Takunori Matsuzaki, Hiraku Oyama, Ryohei Takeuchi, Takuma Takei, Tomoaki Ninomiya, Taisuke Takami, Kouta Inoue, Takanori Nishiguchi, Hiroyasu Hifumi, Emi Shinto, Hiroyuki Takahashi, Hiromi Umemura, Kazuo |
| description | We demonstrate amyloid fibril (AF) decomposition induced by NIR-active upconversion nanoparticles complexed with photosensitisers. The process is triggered by upconversion, which initiates a photochemical reaction cascade that culminates in the generation of the highly reactive singlet-oxygen product
1
O
2
close to the amyloid superstructures, resulting in AF decomposition.
Proposed energy-transfer mechanisms showing the amyloid fibril decomposition process
via
upconversion trigged by NIR excitation. |
| doi_str_mv | 10.1039/c9pp00356h |
| format | Article |
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1
O
2
close to the amyloid superstructures, resulting in AF decomposition.
Proposed energy-transfer mechanisms showing the amyloid fibril decomposition process
via
upconversion trigged by NIR excitation.</description><identifier>ISSN: 1474-905X</identifier><identifier>EISSN: 1474-9092</identifier><identifier>DOI: 10.1039/c9pp00356h</identifier><identifier>PMID: 31932832</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Amyloid - antagonists & inhibitors ; Amyloid - metabolism ; Biochemistry ; Biomaterials ; Chemistry ; Communication ; Decomposition ; Fibrils ; Humans ; Infrared Rays ; Nanoparticles ; Nanoparticles - chemistry ; Photochemical reactions ; Photochemicals ; Photosensitizing Agents - pharmacology ; Physical Chemistry ; Plant Sciences ; Superstructures ; Upconversion</subject><ispartof>Photochemical & photobiological sciences, 2020-01, Vol.19 (1), p.29-33</ispartof><rights>The Royal Society of Chemistry and Owner Societies 2020</rights><rights>Copyright Royal Society of Chemistry 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-3a1cda325a1aba28364c98e2c9f02929683242dffda7d38b68e5eaa679473ee23</citedby><cites>FETCH-LOGICAL-c517t-3a1cda325a1aba28364c98e2c9f02929683242dffda7d38b68e5eaa679473ee23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1039/c9pp00356h$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1039/c9pp00356h$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31932832$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harada, Takunori</creatorcontrib><creatorcontrib>Matsuzaki, Hiraku</creatorcontrib><creatorcontrib>Oyama, Ryohei</creatorcontrib><creatorcontrib>Takeuchi, Takuma</creatorcontrib><creatorcontrib>Takei, Tomoaki</creatorcontrib><creatorcontrib>Ninomiya, Taisuke</creatorcontrib><creatorcontrib>Takami, Kouta</creatorcontrib><creatorcontrib>Inoue, Takanori</creatorcontrib><creatorcontrib>Nishiguchi, Hiroyasu</creatorcontrib><creatorcontrib>Hifumi, Emi</creatorcontrib><creatorcontrib>Shinto, Hiroyuki</creatorcontrib><creatorcontrib>Takahashi, Hiromi</creatorcontrib><creatorcontrib>Umemura, Kazuo</creatorcontrib><title>Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles</title><title>Photochemical & photobiological sciences</title><addtitle>Photochem Photobiol Sci</addtitle><addtitle>Photochem Photobiol Sci</addtitle><description>We demonstrate amyloid fibril (AF) decomposition induced by NIR-active upconversion nanoparticles complexed with photosensitisers. The process is triggered by upconversion, which initiates a photochemical reaction cascade that culminates in the generation of the highly reactive singlet-oxygen product
1
O
2
close to the amyloid superstructures, resulting in AF decomposition.
Proposed energy-transfer mechanisms showing the amyloid fibril decomposition process
via
upconversion trigged by NIR excitation.</description><subject>Amyloid - antagonists & inhibitors</subject><subject>Amyloid - metabolism</subject><subject>Biochemistry</subject><subject>Biomaterials</subject><subject>Chemistry</subject><subject>Communication</subject><subject>Decomposition</subject><subject>Fibrils</subject><subject>Humans</subject><subject>Infrared Rays</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Photochemical reactions</subject><subject>Photochemicals</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Physical Chemistry</subject><subject>Plant Sciences</subject><subject>Superstructures</subject><subject>Upconversion</subject><issn>1474-905X</issn><issn>1474-9092</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9LwzAcxYMobk4v3pWCN6Wan21zlPlrMBREwVtJ01Qz2iYm7WD_vRmdmwdP3y-8D-89HgCnCF4jSPiN5NZCSFjytQfGiKY05pDj_e3PPkbgyPsFhIjRJD0EI4I4wRnBYzC7U9I01njdadNGpopEs6qNLqNKF07XPipW0fPsNRay00sV9VaadqmcX9OtaI0VrtOyVv4YHFSi9upkcyfg_eH-bfoUz18eZ9PbeSwZSruYCCRLQTATSBQilEio5JnCklcQc8yTUIvisqpKkZYkK5JMMSVEknKaEqUwmYCLwdc6890r3-UL07s2ROaYUEwJgwwF6nKgpDPeO1Xl1ulGuFWOYL5eLd-tFuDzjWVfNKrcor8zBeBqAHyQ2k_ldpn_2p0NtPNy6_VH_wHvJoCx</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Harada, Takunori</creator><creator>Matsuzaki, Hiraku</creator><creator>Oyama, Ryohei</creator><creator>Takeuchi, Takuma</creator><creator>Takei, Tomoaki</creator><creator>Ninomiya, Taisuke</creator><creator>Takami, Kouta</creator><creator>Inoue, Takanori</creator><creator>Nishiguchi, Hiroyasu</creator><creator>Hifumi, Emi</creator><creator>Shinto, Hiroyuki</creator><creator>Takahashi, Hiromi</creator><creator>Umemura, Kazuo</creator><general>Springer International Publishing</general><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20200101</creationdate><title>Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles</title><author>Harada, Takunori ; Matsuzaki, Hiraku ; Oyama, Ryohei ; Takeuchi, Takuma ; Takei, Tomoaki ; Ninomiya, Taisuke ; Takami, Kouta ; Inoue, Takanori ; Nishiguchi, Hiroyasu ; Hifumi, Emi ; Shinto, Hiroyuki ; Takahashi, Hiromi ; Umemura, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-3a1cda325a1aba28364c98e2c9f02929683242dffda7d38b68e5eaa679473ee23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amyloid - antagonists & inhibitors</topic><topic>Amyloid - metabolism</topic><topic>Biochemistry</topic><topic>Biomaterials</topic><topic>Chemistry</topic><topic>Communication</topic><topic>Decomposition</topic><topic>Fibrils</topic><topic>Humans</topic><topic>Infrared Rays</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Photochemical reactions</topic><topic>Photochemicals</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Physical Chemistry</topic><topic>Plant Sciences</topic><topic>Superstructures</topic><topic>Upconversion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harada, Takunori</creatorcontrib><creatorcontrib>Matsuzaki, Hiraku</creatorcontrib><creatorcontrib>Oyama, Ryohei</creatorcontrib><creatorcontrib>Takeuchi, Takuma</creatorcontrib><creatorcontrib>Takei, Tomoaki</creatorcontrib><creatorcontrib>Ninomiya, Taisuke</creatorcontrib><creatorcontrib>Takami, Kouta</creatorcontrib><creatorcontrib>Inoue, Takanori</creatorcontrib><creatorcontrib>Nishiguchi, Hiroyasu</creatorcontrib><creatorcontrib>Hifumi, Emi</creatorcontrib><creatorcontrib>Shinto, Hiroyuki</creatorcontrib><creatorcontrib>Takahashi, Hiromi</creatorcontrib><creatorcontrib>Umemura, Kazuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Photochemical & photobiological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harada, Takunori</au><au>Matsuzaki, Hiraku</au><au>Oyama, Ryohei</au><au>Takeuchi, Takuma</au><au>Takei, Tomoaki</au><au>Ninomiya, Taisuke</au><au>Takami, Kouta</au><au>Inoue, Takanori</au><au>Nishiguchi, Hiroyasu</au><au>Hifumi, Emi</au><au>Shinto, Hiroyuki</au><au>Takahashi, Hiromi</au><au>Umemura, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles</atitle><jtitle>Photochemical & photobiological sciences</jtitle><stitle>Photochem Photobiol Sci</stitle><addtitle>Photochem Photobiol Sci</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>19</volume><issue>1</issue><spage>29</spage><epage>33</epage><pages>29-33</pages><issn>1474-905X</issn><eissn>1474-9092</eissn><abstract>We demonstrate amyloid fibril (AF) decomposition induced by NIR-active upconversion nanoparticles complexed with photosensitisers. The process is triggered by upconversion, which initiates a photochemical reaction cascade that culminates in the generation of the highly reactive singlet-oxygen product
1
O
2
close to the amyloid superstructures, resulting in AF decomposition.
Proposed energy-transfer mechanisms showing the amyloid fibril decomposition process
via
upconversion trigged by NIR excitation.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31932832</pmid><doi>10.1039/c9pp00356h</doi><tpages>5</tpages></addata></record> |
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| subjects | Amyloid - antagonists & inhibitors Amyloid - metabolism Biochemistry Biomaterials Chemistry Communication Decomposition Fibrils Humans Infrared Rays Nanoparticles Nanoparticles - chemistry Photochemical reactions Photochemicals Photosensitizing Agents - pharmacology Physical Chemistry Plant Sciences Superstructures Upconversion |
| title | Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles |
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