Environmental determinants associated with acute otitis media in children: a longitudinal study
Background Acute otitis media (AOM) is a common pediatric disease and frequent reason for antibiotic treatment. We aimed to identify environmental and host factors associated with AOM and assess which determinants were associated with AOM at specific ages. Methods This study among 7863 children was...
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| Veröffentlicht in: | Pediatric research 2020-01, Vol.87 (1), p.163-168 |
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| creator | van Ingen, Gijs le Clercq, Carlijn M. P. Touw, Carolina E. Duijts, Liebeth Moll, Henriette A. Jaddoe, Vincent W. V. Raat, Hein Baatenburg de Jong, Robert J. van der Schroeff, Marc P. |
| description | Background
Acute otitis media (AOM) is a common pediatric disease and frequent reason for antibiotic treatment. We aimed to identify environmental and host factors associated with AOM and assess which determinants were associated with AOM at specific ages.
Methods
This study among 7863 children was embedded in the Generation R Study: a population-based prospective cohort study from fetal life onwards. Data on outcome and possible determinants were collected using questionnaires until 6 years. We used generalized estimating equation models to examine associations with AOM with longitudinal odds at different ages, considering correlations between repeated measurements.
Results
Male gender increased odds of AOM in children at 2, 3, and 4 years but not at other ages. Postnatal household smoking, presence of siblings, and pet birds increased odds of AOM. Breastfeeding decreased AOM odds, most notably in the first 2 months of life. No association was found for season of birth, maternal age, ethnicity, aberrant birth weight for gestational age, prenatal smoking, furry pets, and daycare attendance.
Conclusions
Risk of childhood AOM varies with age. Significant association with AOM was found for gender and breastfeeding at specific ages and for household smoking, presence of siblings, and pet birds at all the studied ages. |
| doi_str_mv | 10.1038/s41390-019-0540-3 |
| format | Article |
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Acute otitis media (AOM) is a common pediatric disease and frequent reason for antibiotic treatment. We aimed to identify environmental and host factors associated with AOM and assess which determinants were associated with AOM at specific ages.
Methods
This study among 7863 children was embedded in the Generation R Study: a population-based prospective cohort study from fetal life onwards. Data on outcome and possible determinants were collected using questionnaires until 6 years. We used generalized estimating equation models to examine associations with AOM with longitudinal odds at different ages, considering correlations between repeated measurements.
Results
Male gender increased odds of AOM in children at 2, 3, and 4 years but not at other ages. Postnatal household smoking, presence of siblings, and pet birds increased odds of AOM. Breastfeeding decreased AOM odds, most notably in the first 2 months of life. No association was found for season of birth, maternal age, ethnicity, aberrant birth weight for gestational age, prenatal smoking, furry pets, and daycare attendance.
Conclusions
Risk of childhood AOM varies with age. Significant association with AOM was found for gender and breastfeeding at specific ages and for household smoking, presence of siblings, and pet birds at all the studied ages.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-019-0540-3</identifier><identifier>PMID: 31421634</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Acute Disease ; Animals ; Birds ; Breast Feeding ; Breastfeeding & lactation ; Child ; Child, Preschool ; Ear diseases ; Environment ; Environmental Exposure - adverse effects ; Female ; Humans ; Infant ; Infant, Newborn ; Longitudinal Studies ; Male ; Medicine ; Medicine & Public Health ; Netherlands - epidemiology ; Otitis Media - diagnosis ; Otitis Media - epidemiology ; Pediatric Surgery ; Pediatrics ; Pets ; Population Study Article ; Prospective Studies ; Risk Assessment ; Risk Factors ; Sex Factors ; Siblings ; Tobacco Smoke Pollution - adverse effects</subject><ispartof>Pediatric research, 2020-01, Vol.87 (1), p.163-168</ispartof><rights>International Pediatric Research Foundation, Inc 2019</rights><rights>2019© International Pediatric Research Foundation, Inc 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-8d87923396ec7272506d66fe032470a43f805ac0ef8c90a4bf30efe5401194e73</citedby><cites>FETCH-LOGICAL-c372t-8d87923396ec7272506d66fe032470a43f805ac0ef8c90a4bf30efe5401194e73</cites><orcidid>0000-0002-8883-862X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31421634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Ingen, Gijs</creatorcontrib><creatorcontrib>le Clercq, Carlijn M. P.</creatorcontrib><creatorcontrib>Touw, Carolina E.</creatorcontrib><creatorcontrib>Duijts, Liebeth</creatorcontrib><creatorcontrib>Moll, Henriette A.</creatorcontrib><creatorcontrib>Jaddoe, Vincent W. V.</creatorcontrib><creatorcontrib>Raat, Hein</creatorcontrib><creatorcontrib>Baatenburg de Jong, Robert J.</creatorcontrib><creatorcontrib>van der Schroeff, Marc P.</creatorcontrib><title>Environmental determinants associated with acute otitis media in children: a longitudinal study</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
Acute otitis media (AOM) is a common pediatric disease and frequent reason for antibiotic treatment. We aimed to identify environmental and host factors associated with AOM and assess which determinants were associated with AOM at specific ages.
Methods
This study among 7863 children was embedded in the Generation R Study: a population-based prospective cohort study from fetal life onwards. Data on outcome and possible determinants were collected using questionnaires until 6 years. We used generalized estimating equation models to examine associations with AOM with longitudinal odds at different ages, considering correlations between repeated measurements.
Results
Male gender increased odds of AOM in children at 2, 3, and 4 years but not at other ages. Postnatal household smoking, presence of siblings, and pet birds increased odds of AOM. Breastfeeding decreased AOM odds, most notably in the first 2 months of life. No association was found for season of birth, maternal age, ethnicity, aberrant birth weight for gestational age, prenatal smoking, furry pets, and daycare attendance.
Conclusions
Risk of childhood AOM varies with age. Significant association with AOM was found for gender and breastfeeding at specific ages and for household smoking, presence of siblings, and pet birds at all the studied ages.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Birds</subject><subject>Breast Feeding</subject><subject>Breastfeeding & lactation</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Ear diseases</subject><subject>Environment</subject><subject>Environmental Exposure - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Netherlands - epidemiology</subject><subject>Otitis Media - diagnosis</subject><subject>Otitis Media - epidemiology</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Pets</subject><subject>Population Study Article</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Siblings</subject><subject>Tobacco Smoke Pollution - adverse effects</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kEtPAyEUhYnR2Fr9AW4MietR4DIP3JmmPpImbnRNKMO0NDNMBUbTfy_N-Fi54sI993DPh9AlJTeUQHUbOAVBMkJFRnJOMjhCU5pDeuG8PEZTQoBmIEQ1QWchbAmhPK_4KZoA5YwWwKdILtyH9b3rjIuqxbWJxnfWKRcDViH02qpoavxp4wYrPUSD-2ijDbgztVXYOqw3tq29cXdY4bZ3axuHOhm0OKRif45OGtUGc_F9ztDbw-J1_pQtXx6f5_fLTEPJYlbVVSkYgCiMLlnJclLURdEYAoyXRHFoKpIrTUxTaZHuqwZSbVJoSgU3JczQ9ei78_37YEKU237waY0gGXAGgqfMSUVHlfZ9CN40cudtp_xeUiIPSOWIVCak8oBUQpq5-nYeVin078QPwyRgoyCkllsb__f1_65fNraBaw</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>van Ingen, Gijs</creator><creator>le Clercq, Carlijn M. P.</creator><creator>Touw, Carolina E.</creator><creator>Duijts, Liebeth</creator><creator>Moll, Henriette A.</creator><creator>Jaddoe, Vincent W. V.</creator><creator>Raat, Hein</creator><creator>Baatenburg de Jong, Robert J.</creator><creator>van der Schroeff, Marc P.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-8883-862X</orcidid></search><sort><creationdate>20200101</creationdate><title>Environmental determinants associated with acute otitis media in children: a longitudinal study</title><author>van Ingen, Gijs ; le Clercq, Carlijn M. P. ; Touw, Carolina E. ; Duijts, Liebeth ; Moll, Henriette A. ; Jaddoe, Vincent W. V. ; Raat, Hein ; Baatenburg de Jong, Robert J. ; van der Schroeff, Marc P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-8d87923396ec7272506d66fe032470a43f805ac0ef8c90a4bf30efe5401194e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Birds</topic><topic>Breast Feeding</topic><topic>Breastfeeding & lactation</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Ear diseases</topic><topic>Environment</topic><topic>Environmental Exposure - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Netherlands - epidemiology</topic><topic>Otitis Media - diagnosis</topic><topic>Otitis Media - epidemiology</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Pets</topic><topic>Population Study Article</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Siblings</topic><topic>Tobacco Smoke Pollution - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Ingen, Gijs</creatorcontrib><creatorcontrib>le Clercq, Carlijn M. P.</creatorcontrib><creatorcontrib>Touw, Carolina E.</creatorcontrib><creatorcontrib>Duijts, Liebeth</creatorcontrib><creatorcontrib>Moll, Henriette A.</creatorcontrib><creatorcontrib>Jaddoe, Vincent W. V.</creatorcontrib><creatorcontrib>Raat, Hein</creatorcontrib><creatorcontrib>Baatenburg de Jong, Robert J.</creatorcontrib><creatorcontrib>van der Schroeff, Marc P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Ingen, Gijs</au><au>le Clercq, Carlijn M. P.</au><au>Touw, Carolina E.</au><au>Duijts, Liebeth</au><au>Moll, Henriette A.</au><au>Jaddoe, Vincent W. V.</au><au>Raat, Hein</au><au>Baatenburg de Jong, Robert J.</au><au>van der Schroeff, Marc P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental determinants associated with acute otitis media in children: a longitudinal study</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>87</volume><issue>1</issue><spage>163</spage><epage>168</epage><pages>163-168</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
Acute otitis media (AOM) is a common pediatric disease and frequent reason for antibiotic treatment. We aimed to identify environmental and host factors associated with AOM and assess which determinants were associated with AOM at specific ages.
Methods
This study among 7863 children was embedded in the Generation R Study: a population-based prospective cohort study from fetal life onwards. Data on outcome and possible determinants were collected using questionnaires until 6 years. We used generalized estimating equation models to examine associations with AOM with longitudinal odds at different ages, considering correlations between repeated measurements.
Results
Male gender increased odds of AOM in children at 2, 3, and 4 years but not at other ages. Postnatal household smoking, presence of siblings, and pet birds increased odds of AOM. Breastfeeding decreased AOM odds, most notably in the first 2 months of life. No association was found for season of birth, maternal age, ethnicity, aberrant birth weight for gestational age, prenatal smoking, furry pets, and daycare attendance.
Conclusions
Risk of childhood AOM varies with age. Significant association with AOM was found for gender and breastfeeding at specific ages and for household smoking, presence of siblings, and pet birds at all the studied ages.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>31421634</pmid><doi>10.1038/s41390-019-0540-3</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8883-862X</orcidid></addata></record> |
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| subjects | Acute Disease Animals Birds Breast Feeding Breastfeeding & lactation Child Child, Preschool Ear diseases Environment Environmental Exposure - adverse effects Female Humans Infant Infant, Newborn Longitudinal Studies Male Medicine Medicine & Public Health Netherlands - epidemiology Otitis Media - diagnosis Otitis Media - epidemiology Pediatric Surgery Pediatrics Pets Population Study Article Prospective Studies Risk Assessment Risk Factors Sex Factors Siblings Tobacco Smoke Pollution - adverse effects |
| title | Environmental determinants associated with acute otitis media in children: a longitudinal study |
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