Activity of a Sulfated Polysaccharide Extracted from the Red Seaweed Aghardhiella Tenera against Human Immunodeficiency Virus and Other Enveloped Viruses
A galactan sulfate (GS) was isolated from an aqueous extract of the red seaweed Aghardhiella tenera and partially purified. GS inhibited the cytopathic effect of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) in MT-4 cells at concentrations 10-fold higher than those required for the...
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| Veröffentlicht in: | Antiviral chemistry & chemotherapy 1994-10, Vol.5 (5), p.297-303 |
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| creator | Witvrouw, M. Este, J. A. Mateu, M. Q. Reymen, D. Andrei, G. Snoeck, R. Ikeda, S. Pauwels, R. Bianchini, N. V. Desmyter, J. De Clercq, E. |
| description | A galactan sulfate (GS) was isolated from an aqueous extract of the red seaweed Aghardhiella tenera and partially purified. GS inhibited the cytopathic effect of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) in MT-4 cells at concentrations 10-fold higher than those required for the inhibition by dextran sulfate (MW 5000) of the cytopathic effect of HIV-1 and HIV-2 (50% inhibitory concentrations: 0.5 and 0.05 μg ml−1, respectively). GS suppressed syncytium formation between MOLT-4 cells and persistently HIV-1- or HIV-2-infected HUT-78 cells at concentrations higher than 5 μg ml−1. Like dextran sulfate (DS) and aurintricarboxylic acid (ATA), GS inhibited the binding of HIV-1 to the cells and the binding of anti-gp120 mAb to HIV-1 gp120. Like DS and ATA, GS proved active not only against HIV-1 and HIV-2 but also against other enveloped viruses, i.e. herpes-, toga-, arena-, myxo- and rhabdoviruses. GS represents a natural polysaccharide with broad-spectrum activity against a number of important viral pathogens. |
| doi_str_mv | 10.1177/095632029400500503 |
| format | Article |
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A. ; Mateu, M. Q. ; Reymen, D. ; Andrei, G. ; Snoeck, R. ; Ikeda, S. ; Pauwels, R. ; Bianchini, N. V. ; Desmyter, J. ; De Clercq, E.</creator><creatorcontrib>Witvrouw, M. ; Este, J. A. ; Mateu, M. Q. ; Reymen, D. ; Andrei, G. ; Snoeck, R. ; Ikeda, S. ; Pauwels, R. ; Bianchini, N. V. ; Desmyter, J. ; De Clercq, E.</creatorcontrib><description>A galactan sulfate (GS) was isolated from an aqueous extract of the red seaweed Aghardhiella tenera and partially purified. GS inhibited the cytopathic effect of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) in MT-4 cells at concentrations 10-fold higher than those required for the inhibition by dextran sulfate (MW 5000) of the cytopathic effect of HIV-1 and HIV-2 (50% inhibitory concentrations: 0.5 and 0.05 μg ml−1, respectively). GS suppressed syncytium formation between MOLT-4 cells and persistently HIV-1- or HIV-2-infected HUT-78 cells at concentrations higher than 5 μg ml−1. Like dextran sulfate (DS) and aurintricarboxylic acid (ATA), GS inhibited the binding of HIV-1 to the cells and the binding of anti-gp120 mAb to HIV-1 gp120. Like DS and ATA, GS proved active not only against HIV-1 and HIV-2 but also against other enveloped viruses, i.e. herpes-, toga-, arena-, myxo- and rhabdoviruses. GS represents a natural polysaccharide with broad-spectrum activity against a number of important viral pathogens.</description><identifier>ISSN: 2040-2066</identifier><identifier>ISSN: 0956-3202</identifier><identifier>EISSN: 2040-2066</identifier><identifier>DOI: 10.1177/095632029400500503</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aurintricarboxylic acid ; Biological and medical sciences ; Dextran ; Dextran sulfate ; General pharmacology ; Glycoprotein gp120 ; HIV ; Human immunodeficiency virus ; Medical sciences ; Molting ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. 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A.</au><au>Mateu, M. Q.</au><au>Reymen, D.</au><au>Andrei, G.</au><au>Snoeck, R.</au><au>Ikeda, S.</au><au>Pauwels, R.</au><au>Bianchini, N. V.</au><au>Desmyter, J.</au><au>De Clercq, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activity of a Sulfated Polysaccharide Extracted from the Red Seaweed Aghardhiella Tenera against Human Immunodeficiency Virus and Other Enveloped Viruses</atitle><jtitle>Antiviral chemistry & chemotherapy</jtitle><date>1994-10</date><risdate>1994</risdate><volume>5</volume><issue>5</issue><spage>297</spage><epage>303</epage><pages>297-303</pages><issn>2040-2066</issn><issn>0956-3202</issn><eissn>2040-2066</eissn><abstract>A galactan sulfate (GS) was isolated from an aqueous extract of the red seaweed Aghardhiella tenera and partially purified. GS inhibited the cytopathic effect of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) in MT-4 cells at concentrations 10-fold higher than those required for the inhibition by dextran sulfate (MW 5000) of the cytopathic effect of HIV-1 and HIV-2 (50% inhibitory concentrations: 0.5 and 0.05 μg ml−1, respectively). GS suppressed syncytium formation between MOLT-4 cells and persistently HIV-1- or HIV-2-infected HUT-78 cells at concentrations higher than 5 μg ml−1. Like dextran sulfate (DS) and aurintricarboxylic acid (ATA), GS inhibited the binding of HIV-1 to the cells and the binding of anti-gp120 mAb to HIV-1 gp120. Like DS and ATA, GS proved active not only against HIV-1 and HIV-2 but also against other enveloped viruses, i.e. herpes-, toga-, arena-, myxo- and rhabdoviruses. GS represents a natural polysaccharide with broad-spectrum activity against a number of important viral pathogens.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><doi>10.1177/095632029400500503</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aurintricarboxylic acid Biological and medical sciences Dextran Dextran sulfate General pharmacology Glycoprotein gp120 HIV Human immunodeficiency virus Medical sciences Molting Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Polysaccharides Seaweeds |
| title | Activity of a Sulfated Polysaccharide Extracted from the Red Seaweed Aghardhiella Tenera against Human Immunodeficiency Virus and Other Enveloped Viruses |
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