Effects of a Specific Inhibitor of HIV Proteinase (Ro 31-8959) on Virus Maturation in a Chronically Infected Promonocytic Cell Line (U1)

The human immunodeficiency virus (HIV) proteinase inhibitor Ro 31-8959 prevents the maturation of virus in phorbol 12-myristate 13-acetate (PMA)-stimulated U1 cells, a chronically infected promonocytic cell line. Inhibition of both the morphological maturation of virions and the enzymic processing o...

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Veröffentlicht in:	Antiviral chemistry & chemotherapy 1991-06, Vol.2 (3), p.181-186
Hauptverfasser:	Craig, J. C., Grief, C., Mills, J. S., Hockley, D., Duncan, I. B., Roberts, N. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Capsid protein Gag protein HIV Human immunodeficiency virus Medical sciences Pharmacology. Drug treatments Phorbol 12-myristate 13-acetate Proteinase Proteinase inhibitors Virions
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