Drugs for conversion of atrial fibrillation
Atrial fibrillation is the most common arrhythmia in patients visiting a primary care practice. Although many patients with atrial fibrillation experience relief of symptoms with control of the heart rate, some patients require restoration of sinus rhythm. External direct current (DC) cardioversion...
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| Veröffentlicht in: | American family physician 1998-08, Vol.58 (2), p.471 |
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| creator | Dell'Orfano, J T Luck, J C Wolbrette, D L Patel, H Naccarelli, G V |
| description | Atrial fibrillation is the most common arrhythmia in patients visiting a primary care practice. Although many patients with atrial fibrillation experience relief of symptoms with control of the heart rate, some patients require restoration of sinus rhythm. External direct current (DC) cardioversion is the most effective means of converting atrial fibrillation to sinus rhythm. Pharmacologic cardioversion, although less effective, offers an alternative to DC cardioversion. Several advances have been made in antiarrhythmic medications, including the development of ibutilide, a class III antiarrhythmic drug indicated for acute cardioversion of atrial fibrillation. Other methods of pharmacologic and nonpharmacologic cardioversion remain under development. Until the results of several large-scale randomized clinical trials are available, the decision to choose cardioversion or maintenance of sinus rhythm must be individualized, based on relief of symptoms and reduction of the morbidity and mortality associated with atrial fibrillation. |
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Although many patients with atrial fibrillation experience relief of symptoms with control of the heart rate, some patients require restoration of sinus rhythm. External direct current (DC) cardioversion is the most effective means of converting atrial fibrillation to sinus rhythm. Pharmacologic cardioversion, although less effective, offers an alternative to DC cardioversion. Several advances have been made in antiarrhythmic medications, including the development of ibutilide, a class III antiarrhythmic drug indicated for acute cardioversion of atrial fibrillation. Other methods of pharmacologic and nonpharmacologic cardioversion remain under development. Until the results of several large-scale randomized clinical trials are available, the decision to choose cardioversion or maintenance of sinus rhythm must be individualized, based on relief of symptoms and reduction of the morbidity and mortality associated with atrial fibrillation.</description><identifier>ISSN: 0002-838X</identifier><identifier>PMID: 9713400</identifier><identifier>CODEN: AFPYBF</identifier><language>eng</language><publisher>United States: American Academy of Family Physicians</publisher><subject>Acute Disease ; Algorithms ; Anti-Arrhythmia Agents - adverse effects ; Anti-Arrhythmia Agents - therapeutic use ; Atrial Fibrillation - drug therapy ; Cardiac arrhythmia ; Cardiovascular Agents - therapeutic use ; Drug therapy ; Drugs ; Humans ; Pharmacology</subject><ispartof>American family physician, 1998-08, Vol.58 (2), p.471</ispartof><rights>Copyright American Academy of Family Physicians Aug 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9713400$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dell'Orfano, J T</creatorcontrib><creatorcontrib>Luck, J C</creatorcontrib><creatorcontrib>Wolbrette, D L</creatorcontrib><creatorcontrib>Patel, H</creatorcontrib><creatorcontrib>Naccarelli, G V</creatorcontrib><title>Drugs for conversion of atrial fibrillation</title><title>American family physician</title><addtitle>Am Fam Physician</addtitle><description>Atrial fibrillation is the most common arrhythmia in patients visiting a primary care practice. Although many patients with atrial fibrillation experience relief of symptoms with control of the heart rate, some patients require restoration of sinus rhythm. External direct current (DC) cardioversion is the most effective means of converting atrial fibrillation to sinus rhythm. Pharmacologic cardioversion, although less effective, offers an alternative to DC cardioversion. Several advances have been made in antiarrhythmic medications, including the development of ibutilide, a class III antiarrhythmic drug indicated for acute cardioversion of atrial fibrillation. Other methods of pharmacologic and nonpharmacologic cardioversion remain under development. 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Although many patients with atrial fibrillation experience relief of symptoms with control of the heart rate, some patients require restoration of sinus rhythm. External direct current (DC) cardioversion is the most effective means of converting atrial fibrillation to sinus rhythm. Pharmacologic cardioversion, although less effective, offers an alternative to DC cardioversion. Several advances have been made in antiarrhythmic medications, including the development of ibutilide, a class III antiarrhythmic drug indicated for acute cardioversion of atrial fibrillation. Other methods of pharmacologic and nonpharmacologic cardioversion remain under development. Until the results of several large-scale randomized clinical trials are available, the decision to choose cardioversion or maintenance of sinus rhythm must be individualized, based on relief of symptoms and reduction of the morbidity and mortality associated with atrial fibrillation.</abstract><cop>United States</cop><pub>American Academy of Family Physicians</pub><pmid>9713400</pmid></addata></record> |
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| identifier | ISSN: 0002-838X |
| ispartof | American family physician, 1998-08, Vol.58 (2), p.471 |
| issn | 0002-838X |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Acute Disease Algorithms Anti-Arrhythmia Agents - adverse effects Anti-Arrhythmia Agents - therapeutic use Atrial Fibrillation - drug therapy Cardiac arrhythmia Cardiovascular Agents - therapeutic use Drug therapy Drugs Humans Pharmacology |
| title | Drugs for conversion of atrial fibrillation |
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