Ontogeny of gonadotrophin‐inhibitory hormone in the cichlid fish Cichlasoma dimerus
RF amide peptides are expressed in the early stages of development in most vertebrates. Gonadotrophin‐inhibitory hormone (Gn IH ) belongs to the RF amide family, and its role in reproduction has been widely studied in adult vertebrates, ranging from fish to mammals. Because only 3 reports have evalu...
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| creator | Di Yorio, M. P. Sallemi, J. E. Toledo Solís, F. J. Pérez Sirkin, D. I. Delgadin, T. H. Tsutsui, K. Vissio, P. G. |
| description | RF
amide peptides are expressed in the early stages of development in most vertebrates. Gonadotrophin‐inhibitory hormone (Gn
IH
) belongs to the
RF
amide family, and its role in reproduction has been widely studied in adult vertebrates, ranging from fish to mammals. Because only 3 reports have evaluated Gn
IH
during development, the present study aimed to characterise the ontogeny of Gn
IH
in the fish model
Cichlasoma dimerus
. We detected the presence of 2 Gn
IH
‐immunoreactive (‐IR) cell clusters with spatial and temporal differences. One cluster was observed by 3 days post‐hatching (dph) in the nucleus olfacto‐retinalis (
NOR
) and the other in the nucleus posterioris periventricularis by 14 dph. The number of Gn
IH
‐IR neurones increased in both nuclei, whereas their size increased only in the
NOR
from hatchling to juvenile stages. These changes occurred from the moment that larvae started feeding exogenously and during development and differentiation of gonadal primordia. We showed by double‐label immunofluorescence that only Gn
IH
‐IR neurones in the
NOR
co‐expressed gonadotrophin‐releasing hormone 3 associated peptide. In addition, Gn
IH
‐IR fibre density increased in all brain regions from 5 dph. Gn
IH
‐IR fibres were also detected in the retina, optic tract and optic tectum, suggesting that Gn
IH
acts as a neuromodulator of photoreception and the integration of different sensory modalities. Furthermore, there were Gn
IH
‐IR fibres in the pituitary from 14 dph, which were in close association with somatotrophs. Moreover, Gn
IH
‐IR fibres were observed in the saccus vasculosus from 30 dph, suggesting a potential role of Gn
IH
in the modulation of its function. Finally, we found that
gnih
was expressed from 1 dph, and that the pattern of variation of its transcript levels was in accordance with that of cell number. The results of the present study comprise a starting point for the study of new Gn
IH
roles during development. |
| doi_str_mv | 10.1111/jne.12608 |
| format | Article |
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amide peptides are expressed in the early stages of development in most vertebrates. Gonadotrophin‐inhibitory hormone (Gn
IH
) belongs to the
RF
amide family, and its role in reproduction has been widely studied in adult vertebrates, ranging from fish to mammals. Because only 3 reports have evaluated Gn
IH
during development, the present study aimed to characterise the ontogeny of Gn
IH
in the fish model
Cichlasoma dimerus
. We detected the presence of 2 Gn
IH
‐immunoreactive (‐IR) cell clusters with spatial and temporal differences. One cluster was observed by 3 days post‐hatching (dph) in the nucleus olfacto‐retinalis (
NOR
) and the other in the nucleus posterioris periventricularis by 14 dph. The number of Gn
IH
‐IR neurones increased in both nuclei, whereas their size increased only in the
NOR
from hatchling to juvenile stages. These changes occurred from the moment that larvae started feeding exogenously and during development and differentiation of gonadal primordia. We showed by double‐label immunofluorescence that only Gn
IH
‐IR neurones in the
NOR
co‐expressed gonadotrophin‐releasing hormone 3 associated peptide. In addition, Gn
IH
‐IR fibre density increased in all brain regions from 5 dph. Gn
IH
‐IR fibres were also detected in the retina, optic tract and optic tectum, suggesting that Gn
IH
acts as a neuromodulator of photoreception and the integration of different sensory modalities. Furthermore, there were Gn
IH
‐IR fibres in the pituitary from 14 dph, which were in close association with somatotrophs. Moreover, Gn
IH
‐IR fibres were observed in the saccus vasculosus from 30 dph, suggesting a potential role of Gn
IH
in the modulation of its function. Finally, we found that
gnih
was expressed from 1 dph, and that the pattern of variation of its transcript levels was in accordance with that of cell number. The results of the present study comprise a starting point for the study of new Gn
IH
roles during development.</description><identifier>ISSN: 0953-8194</identifier><identifier>EISSN: 1365-2826</identifier><identifier>DOI: 10.1111/jne.12608</identifier><language>eng</language><publisher>Oxford: Wiley Subscription Services, Inc</publisher><subject>Cell number ; Cichlasoma dimerus ; Developmental stages ; Fibers ; Hatching ; Immunofluorescence ; Larvae ; Neuromodulation ; Ontogeny ; Optic tract ; Pituitary ; Pituitary (anterior) ; Primordia ; Retina ; Sensory integration ; Superior colliculus ; Tectum ; Transcription</subject><ispartof>Journal of neuroendocrinology, 2018-06, Vol.30 (6)</ispartof><rights>Copyright © 2018 British Society for Neuroendocrinology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-281e4bde8cafe4908f6210106fa27641d2aba379b4a3e531edd86897e3a10ffb3</citedby><cites>FETCH-LOGICAL-c358t-281e4bde8cafe4908f6210106fa27641d2aba379b4a3e531edd86897e3a10ffb3</cites><orcidid>0000-0002-0240-9534</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Di Yorio, M. P.</creatorcontrib><creatorcontrib>Sallemi, J. E.</creatorcontrib><creatorcontrib>Toledo Solís, F. J.</creatorcontrib><creatorcontrib>Pérez Sirkin, D. I.</creatorcontrib><creatorcontrib>Delgadin, T. H.</creatorcontrib><creatorcontrib>Tsutsui, K.</creatorcontrib><creatorcontrib>Vissio, P. G.</creatorcontrib><title>Ontogeny of gonadotrophin‐inhibitory hormone in the cichlid fish Cichlasoma dimerus</title><title>Journal of neuroendocrinology</title><description>RF
amide peptides are expressed in the early stages of development in most vertebrates. Gonadotrophin‐inhibitory hormone (Gn
IH
) belongs to the
RF
amide family, and its role in reproduction has been widely studied in adult vertebrates, ranging from fish to mammals. Because only 3 reports have evaluated Gn
IH
during development, the present study aimed to characterise the ontogeny of Gn
IH
in the fish model
Cichlasoma dimerus
. We detected the presence of 2 Gn
IH
‐immunoreactive (‐IR) cell clusters with spatial and temporal differences. One cluster was observed by 3 days post‐hatching (dph) in the nucleus olfacto‐retinalis (
NOR
) and the other in the nucleus posterioris periventricularis by 14 dph. The number of Gn
IH
‐IR neurones increased in both nuclei, whereas their size increased only in the
NOR
from hatchling to juvenile stages. These changes occurred from the moment that larvae started feeding exogenously and during development and differentiation of gonadal primordia. We showed by double‐label immunofluorescence that only Gn
IH
‐IR neurones in the
NOR
co‐expressed gonadotrophin‐releasing hormone 3 associated peptide. In addition, Gn
IH
‐IR fibre density increased in all brain regions from 5 dph. Gn
IH
‐IR fibres were also detected in the retina, optic tract and optic tectum, suggesting that Gn
IH
acts as a neuromodulator of photoreception and the integration of different sensory modalities. Furthermore, there were Gn
IH
‐IR fibres in the pituitary from 14 dph, which were in close association with somatotrophs. Moreover, Gn
IH
‐IR fibres were observed in the saccus vasculosus from 30 dph, suggesting a potential role of Gn
IH
in the modulation of its function. Finally, we found that
gnih
was expressed from 1 dph, and that the pattern of variation of its transcript levels was in accordance with that of cell number. The results of the present study comprise a starting point for the study of new Gn
IH
roles during development.</description><subject>Cell number</subject><subject>Cichlasoma dimerus</subject><subject>Developmental stages</subject><subject>Fibers</subject><subject>Hatching</subject><subject>Immunofluorescence</subject><subject>Larvae</subject><subject>Neuromodulation</subject><subject>Ontogeny</subject><subject>Optic tract</subject><subject>Pituitary</subject><subject>Pituitary (anterior)</subject><subject>Primordia</subject><subject>Retina</subject><subject>Sensory integration</subject><subject>Superior colliculus</subject><subject>Tectum</subject><subject>Transcription</subject><issn>0953-8194</issn><issn>1365-2826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNotkE1OwzAUhC0EEqWw4AaWWLFI8U_iOEtUQUGq1A1dW0783Dhq7GCni-44AmfkJKSU2YxGGs17-hC6p2RBJz11HhaUCSIv0IxyUWRMMnGJZqQqeCZplV-jm5Q6QmhZcDJD240fww78EQeLd8FrE8YYhtb5n69v51tXuzHEI25D7IMH7DweW8CNa9q9M9i61OLlKegUeo2N6yEe0i26snqf4O7f52j7-vKxfMvWm9X78nmdNbyQ4_Qbhbw2IBttIa-ItIJRQomwmpUip4bpWvOyqnPNoeAUjJFCViVwTYm1NZ-jh_PuEMPnAdKounCIfjqpGM8nDqISfGo9nltNDClFsGqIrtfxqChRJ2pqoqb-qPFfeQ5hqw</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Di Yorio, M. P.</creator><creator>Sallemi, J. E.</creator><creator>Toledo Solís, F. J.</creator><creator>Pérez Sirkin, D. I.</creator><creator>Delgadin, T. H.</creator><creator>Tsutsui, K.</creator><creator>Vissio, P. G.</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-0240-9534</orcidid></search><sort><creationdate>20180601</creationdate><title>Ontogeny of gonadotrophin‐inhibitory hormone in the cichlid fish Cichlasoma dimerus</title><author>Di Yorio, M. P. ; Sallemi, J. E. ; Toledo Solís, F. J. ; Pérez Sirkin, D. I. ; Delgadin, T. H. ; Tsutsui, K. ; Vissio, P. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-281e4bde8cafe4908f6210106fa27641d2aba379b4a3e531edd86897e3a10ffb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cell number</topic><topic>Cichlasoma dimerus</topic><topic>Developmental stages</topic><topic>Fibers</topic><topic>Hatching</topic><topic>Immunofluorescence</topic><topic>Larvae</topic><topic>Neuromodulation</topic><topic>Ontogeny</topic><topic>Optic tract</topic><topic>Pituitary</topic><topic>Pituitary (anterior)</topic><topic>Primordia</topic><topic>Retina</topic><topic>Sensory integration</topic><topic>Superior colliculus</topic><topic>Tectum</topic><topic>Transcription</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Di Yorio, M. P.</creatorcontrib><creatorcontrib>Sallemi, J. E.</creatorcontrib><creatorcontrib>Toledo Solís, F. J.</creatorcontrib><creatorcontrib>Pérez Sirkin, D. I.</creatorcontrib><creatorcontrib>Delgadin, T. H.</creatorcontrib><creatorcontrib>Tsutsui, K.</creatorcontrib><creatorcontrib>Vissio, P. G.</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of neuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Yorio, M. P.</au><au>Sallemi, J. E.</au><au>Toledo Solís, F. J.</au><au>Pérez Sirkin, D. I.</au><au>Delgadin, T. H.</au><au>Tsutsui, K.</au><au>Vissio, P. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ontogeny of gonadotrophin‐inhibitory hormone in the cichlid fish Cichlasoma dimerus</atitle><jtitle>Journal of neuroendocrinology</jtitle><date>2018-06-01</date><risdate>2018</risdate><volume>30</volume><issue>6</issue><issn>0953-8194</issn><eissn>1365-2826</eissn><abstract>RF
amide peptides are expressed in the early stages of development in most vertebrates. Gonadotrophin‐inhibitory hormone (Gn
IH
) belongs to the
RF
amide family, and its role in reproduction has been widely studied in adult vertebrates, ranging from fish to mammals. Because only 3 reports have evaluated Gn
IH
during development, the present study aimed to characterise the ontogeny of Gn
IH
in the fish model
Cichlasoma dimerus
. We detected the presence of 2 Gn
IH
‐immunoreactive (‐IR) cell clusters with spatial and temporal differences. One cluster was observed by 3 days post‐hatching (dph) in the nucleus olfacto‐retinalis (
NOR
) and the other in the nucleus posterioris periventricularis by 14 dph. The number of Gn
IH
‐IR neurones increased in both nuclei, whereas their size increased only in the
NOR
from hatchling to juvenile stages. These changes occurred from the moment that larvae started feeding exogenously and during development and differentiation of gonadal primordia. We showed by double‐label immunofluorescence that only Gn
IH
‐IR neurones in the
NOR
co‐expressed gonadotrophin‐releasing hormone 3 associated peptide. In addition, Gn
IH
‐IR fibre density increased in all brain regions from 5 dph. Gn
IH
‐IR fibres were also detected in the retina, optic tract and optic tectum, suggesting that Gn
IH
acts as a neuromodulator of photoreception and the integration of different sensory modalities. Furthermore, there were Gn
IH
‐IR fibres in the pituitary from 14 dph, which were in close association with somatotrophs. Moreover, Gn
IH
‐IR fibres were observed in the saccus vasculosus from 30 dph, suggesting a potential role of Gn
IH
in the modulation of its function. Finally, we found that
gnih
was expressed from 1 dph, and that the pattern of variation of its transcript levels was in accordance with that of cell number. The results of the present study comprise a starting point for the study of new Gn
IH
roles during development.</abstract><cop>Oxford</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1111/jne.12608</doi><orcidid>https://orcid.org/0000-0002-0240-9534</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of neuroendocrinology, 2018-06, Vol.30 (6) |
| issn | 0953-8194 1365-2826 |
| language | eng |
| recordid | cdi_proquest_journals_2341266963 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Cell number Cichlasoma dimerus Developmental stages Fibers Hatching Immunofluorescence Larvae Neuromodulation Ontogeny Optic tract Pituitary Pituitary (anterior) Primordia Retina Sensory integration Superior colliculus Tectum Transcription |
| title | Ontogeny of gonadotrophin‐inhibitory hormone in the cichlid fish Cichlasoma dimerus |
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