Longitudinal Changes of Plasma ADAMTS13 Activity, Antigen, and Autoantibodies in Patients With Immune-Mediated Thrombotic Thrombocytopenic Purpura

Abstract Background Severe deficiency of plasma ADAMTS13 activity resulting from anti-ADAMTS13 IgG is the primary cause of immune-mediated thrombotic thrombocytopenic purpura (iTTP). Anti-ADAMTS13 IgG may bind and inhibit plasma ADAMTS13 activity and/or accelerate clearance of ADAMTS13 from the circ...

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Veröffentlicht in:	American journal of clinical pathology 2019-09, Vol.152 (Supplement_1), p.S21-S22
Hauptverfasser:	Sui, Jingrui (Jean), Cao, Wenjing, Abdelgawwad, Mohammad, Kocher, Nicole K, Halkidis, Konstantine, Guillory, Bryan K, Williams, Lawrence A, Marques, Marisa B, Zheng, X Long
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Autoantibodies Corticosteroids Diagnosis Electronic medical records Hemolytic anemia Immune clearance Immunoglobulin G Patients Plasma Plasma levels Survival analysis Thrombocytopenia Thrombocytopenic purpura Thrombotic thrombocytopenic purpura
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