Successful Treatment of Tardive Dystonia with Clozapine and Clonazepam
Tardive dystonia is an uncommon complication of neuroleptic treatment which is frequently disabling and poorly responsive to treatment. The case is reported of a 28-year-old patient with schizophrenia who developed severe, generalised tardive dystonia after five years of neuroleptic treatment. Stopp...
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| Veröffentlicht in: | British journal of psychiatry 1996-04, Vol.168 (4), p.516-518 |
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| creator | Shapleske, J. Mckay, A. P. Mckenna, P. J. |
| description | Tardive dystonia is an uncommon complication of neuroleptic treatment which is frequently disabling and poorly responsive to treatment.
The case is reported of a 28-year-old patient with schizophrenia who developed severe, generalised tardive dystonia after five years of neuroleptic treatment. Stopping neuroleptic medication and treatment with tetrabenazine, an anticholinergic and a benzodiazepine were ineffective. Treatment with clozapine and then the novel combination of clozapine plus clonazepam was instituted.
Treatment with clozapine alone brought about limited improvement. Addition of clonazepam resulted in virtually complete disappearance of all abnormal movements. This remission has been sustained for nearly two years.
This report adds to two other cases suggesting that the combination of clozapine and clonazepam may be an effective treatment for tardive dystonia. |
| doi_str_mv | 10.1192/bjp.168.4.516 |
| format | Article |
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The case is reported of a 28-year-old patient with schizophrenia who developed severe, generalised tardive dystonia after five years of neuroleptic treatment. Stopping neuroleptic medication and treatment with tetrabenazine, an anticholinergic and a benzodiazepine were ineffective. Treatment with clozapine and then the novel combination of clozapine plus clonazepam was instituted.
Treatment with clozapine alone brought about limited improvement. Addition of clonazepam resulted in virtually complete disappearance of all abnormal movements. This remission has been sustained for nearly two years.
This report adds to two other cases suggesting that the combination of clozapine and clonazepam may be an effective treatment for tardive dystonia.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.168.4.516</identifier><identifier>PMID: 8730951</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Anticholinergics ; Anticonvulsants - therapeutic use ; Antipsychotic Agents - adverse effects ; Antipsychotic Agents - therapeutic use ; Antipsychotics ; Benzodiazepines ; Clonazepam ; Clonazepam - therapeutic use ; Clozapine ; Clozapine - therapeutic use ; Disappearance ; Drug Therapy, Combination ; Drugs ; Dystonia ; Dystonia - chemically induced ; Dystonia - diagnosis ; Dystonia - drug therapy ; Female ; Humans ; Mental disorders ; Neurologic Examination - drug effects ; Remission ; Remission (Medicine) ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - drug therapy ; Schizophrenic Psychology ; Tetrabenazine</subject><ispartof>British journal of psychiatry, 1996-04, Vol.168 (4), p.516-518</ispartof><rights>Copyright © Royal College of Psychiatrists, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-531d5f975fcd1e4052465afde5658cdbdfba8d13c4113361efc40443351bd6383</citedby><cites>FETCH-LOGICAL-c382t-531d5f975fcd1e4052465afde5658cdbdfba8d13c4113361efc40443351bd6383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007125000076716/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,12826,27903,27904,30978,55606</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8730951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shapleske, J.</creatorcontrib><creatorcontrib>Mckay, A. P.</creatorcontrib><creatorcontrib>Mckenna, P. J.</creatorcontrib><title>Successful Treatment of Tardive Dystonia with Clozapine and Clonazepam</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry</addtitle><description>Tardive dystonia is an uncommon complication of neuroleptic treatment which is frequently disabling and poorly responsive to treatment.
The case is reported of a 28-year-old patient with schizophrenia who developed severe, generalised tardive dystonia after five years of neuroleptic treatment. Stopping neuroleptic medication and treatment with tetrabenazine, an anticholinergic and a benzodiazepine were ineffective. Treatment with clozapine and then the novel combination of clozapine plus clonazepam was instituted.
Treatment with clozapine alone brought about limited improvement. Addition of clonazepam resulted in virtually complete disappearance of all abnormal movements. This remission has been sustained for nearly two years.
This report adds to two other cases suggesting that the combination of clozapine and clonazepam may be an effective treatment for tardive dystonia.</description><subject>Adult</subject><subject>Anticholinergics</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Antipsychotic Agents - adverse effects</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Antipsychotics</subject><subject>Benzodiazepines</subject><subject>Clonazepam</subject><subject>Clonazepam - therapeutic use</subject><subject>Clozapine</subject><subject>Clozapine - therapeutic use</subject><subject>Disappearance</subject><subject>Drug Therapy, Combination</subject><subject>Drugs</subject><subject>Dystonia</subject><subject>Dystonia - chemically induced</subject><subject>Dystonia - diagnosis</subject><subject>Dystonia - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Mental disorders</subject><subject>Neurologic Examination - drug effects</subject><subject>Remission</subject><subject>Remission (Medicine)</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenic Psychology</subject><subject>Tetrabenazine</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkEtLAzEUhYMoWh9Ll8KI62lz85hJl1KtCoIL6zpk8rBTOg-TGUv99aZ0UARXl8M9nHP4ELoEPAaYkkmxaseQiTEbc8gO0AhYTlJgGT9EI4xxngLh-ASdhrCKkjKSH6NjkVM85TBC89deaxuC69fJwlvVVbbuksYlC-VN-WmTu23omrpUyabslsls3XyptqxtomqzU7X6sq2qztGRU-tgL4Z7ht7m94vZY_r88vA0u31ONRWkSzkFw900504bsAxzEncqZyzPuNCmMK5QwgDVDIDSDKzTDDNGKYfCZFTQM3Szz21989Hb0MlV0_s6VkpCqQAiiMDRle5d2jcheOtk68tK-a0ELHfQZIQmIzTJZIQW_VdDal9U1vy4B0rxf73_L8v35ab0Vnrdhq1e_smYDJ2qKnxp3u3vtP9bvwFg3YHw</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>Shapleske, J.</creator><creator>Mckay, A. 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P.</au><au>Mckenna, P. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful Treatment of Tardive Dystonia with Clozapine and Clonazepam</atitle><jtitle>British journal of psychiatry</jtitle><addtitle>Br J Psychiatry</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>168</volume><issue>4</issue><spage>516</spage><epage>518</epage><pages>516-518</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><abstract>Tardive dystonia is an uncommon complication of neuroleptic treatment which is frequently disabling and poorly responsive to treatment.
The case is reported of a 28-year-old patient with schizophrenia who developed severe, generalised tardive dystonia after five years of neuroleptic treatment. Stopping neuroleptic medication and treatment with tetrabenazine, an anticholinergic and a benzodiazepine were ineffective. Treatment with clozapine and then the novel combination of clozapine plus clonazepam was instituted.
Treatment with clozapine alone brought about limited improvement. Addition of clonazepam resulted in virtually complete disappearance of all abnormal movements. This remission has been sustained for nearly two years.
This report adds to two other cases suggesting that the combination of clozapine and clonazepam may be an effective treatment for tardive dystonia.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>8730951</pmid><doi>10.1192/bjp.168.4.516</doi><tpages>3</tpages></addata></record> |
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| ispartof | British journal of psychiatry, 1996-04, Vol.168 (4), p.516-518 |
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| source | MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); Cambridge University Press Journals Complete |
| subjects | Adult Anticholinergics Anticonvulsants - therapeutic use Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Antipsychotics Benzodiazepines Clonazepam Clonazepam - therapeutic use Clozapine Clozapine - therapeutic use Disappearance Drug Therapy, Combination Drugs Dystonia Dystonia - chemically induced Dystonia - diagnosis Dystonia - drug therapy Female Humans Mental disorders Neurologic Examination - drug effects Remission Remission (Medicine) Schizophrenia Schizophrenia - diagnosis Schizophrenia - drug therapy Schizophrenic Psychology Tetrabenazine |
| title | Successful Treatment of Tardive Dystonia with Clozapine and Clonazepam |
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