The ameliorating effects of Bushen Tiaoxue Granules and Kunling Wan on impaired angiogenesis and endometrial receptivity in rats following controlled ovarian hyperstimulation
Objective To investigate the effects of Bushen Tiaoxue Granules and Kunling Wan, the two Chinese medicines, on vascular dysfunction and the impairment of endometrial receptivity caused by controlled ovarian hyperstimulation and its underlying mechanism. Methods Female Sprague Dawley rats with regula...
Gespeichert in:
| Veröffentlicht in: | Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2020-01, Vol.27 (1), p.e12581-n/a |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 1 |
| container_start_page | e12581 |
| container_title | Microcirculation (New York, N.Y. 1994) |
| container_volume | 27 |
| creator | Lv, Bo‐Yang Sun, Hao‐Yu Li, Quan Zhang, Hao‐Lin Pan, Chun‐Shui Yan, Li Fan, Jing‐Yu Li, Dong Han, Jing‐Yan |
| description | Objective
To investigate the effects of Bushen Tiaoxue Granules and Kunling Wan, the two Chinese medicines, on vascular dysfunction and the impairment of endometrial receptivity caused by controlled ovarian hyperstimulation and its underlying mechanism.
Methods
Female Sprague Dawley rats with regular estrous cycle were enrolled and given Bushen Tiaoxue Granules or Kunling Wan by gavage for 12 days, and then, controlled ovarian hyperstimulation model was induced. We assessed endometrial microvessels, endometrial blood flow, levels of estradiol and progesterone in serum, vascular endothelial growth factor A upstream molecules estrogen and progesterone receptors in the endometrium, and pregnancy outcome.
Results
Pre‐treatment of Bushen Tiaoxue Granules or Kunling Wan increases endometrial blood flow of controlled ovarian hyperstimulation rats, up‐regulates vascular endothelial growth factor A and microvessels, improves the endometrial morphology of controlled ovarian hyperstimulation rats during implantation, decreases the super physiological concentration of estradiol and progesterone in serum, and increases the expression of vascular endothelial growth factor A upstream molecules estrogen and progesterone receptors in the endometrium. In addition, Bushen Tiaoxue Granules or Kunling Wan elevates the lysophosphatidic acid receptor 3 that participates in vascularization and increases the expression of leukemia inhibitory factor through up‐regulating the expression of p53 in the endometrium, ultimately affecting pregnancy outcome.
Conclusion
This study demonstrated Bushen Tiaoxue Granules or Kunling Wan as a potential strategy for prevention of impairment in angiogenesis and endometrial receptivity induced by controlled ovarian hyperstimulation. |
| doi_str_mv | 10.1111/micc.12581 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2336956350</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2336956350</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3571-c205ad07939bc681172dd43ca86888958ed12179b948c837d3a4528653c776423</originalsourceid><addsrcrecordid>eNp9kUFvFCEYhompsbV66Q9oSHozmQrDMMCx3WhtrPGyxuOEhW92aRgYYWbr_il_o6xTPQoHIDzf8xFehC4ouaZlvB-cMde05pK-QGeUN6qSgqqTsieCVaqV8hS9zvmRECJlrV6hU0bLbAg_Q7_WO8B6AO9i0pMLWwx9D2bKOPb4ds47CHjtdPw5A75LOsweMtbB4s9z8Ef8uw44BuyGUbsEttxtXdxCgOwWEIKNA0zJaY8TGBgnt3fTAbuAS8eM--h9fDqqTAxTKqdiiXtdCgLeHUZIeXLD7MvrYniDXvbaZ3j7vJ6jbx8_rFefqoevd_erm4fKMC5oZWrCtSVCMbUxraRU1NY2zGhZPkMqLsHSmgq1UY00kgnLdMNr2XJmhGibmp2jq8U7pvhjhjx1j3FOobTsasZaxVvGSaHeLZRJMecEfTcmN-h06CjpjtF0x2i6P9EU-PJZOW8GsP_Qv1kUgC7Ak_Nw-I-q-3K_Wi3S3yE8nGA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2336956350</pqid></control><display><type>article</type><title>The ameliorating effects of Bushen Tiaoxue Granules and Kunling Wan on impaired angiogenesis and endometrial receptivity in rats following controlled ovarian hyperstimulation</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Lv, Bo‐Yang ; Sun, Hao‐Yu ; Li, Quan ; Zhang, Hao‐Lin ; Pan, Chun‐Shui ; Yan, Li ; Fan, Jing‐Yu ; Li, Dong ; Han, Jing‐Yan</creator><creatorcontrib>Lv, Bo‐Yang ; Sun, Hao‐Yu ; Li, Quan ; Zhang, Hao‐Lin ; Pan, Chun‐Shui ; Yan, Li ; Fan, Jing‐Yu ; Li, Dong ; Han, Jing‐Yan</creatorcontrib><description>Objective
To investigate the effects of Bushen Tiaoxue Granules and Kunling Wan, the two Chinese medicines, on vascular dysfunction and the impairment of endometrial receptivity caused by controlled ovarian hyperstimulation and its underlying mechanism.
Methods
Female Sprague Dawley rats with regular estrous cycle were enrolled and given Bushen Tiaoxue Granules or Kunling Wan by gavage for 12 days, and then, controlled ovarian hyperstimulation model was induced. We assessed endometrial microvessels, endometrial blood flow, levels of estradiol and progesterone in serum, vascular endothelial growth factor A upstream molecules estrogen and progesterone receptors in the endometrium, and pregnancy outcome.
Results
Pre‐treatment of Bushen Tiaoxue Granules or Kunling Wan increases endometrial blood flow of controlled ovarian hyperstimulation rats, up‐regulates vascular endothelial growth factor A and microvessels, improves the endometrial morphology of controlled ovarian hyperstimulation rats during implantation, decreases the super physiological concentration of estradiol and progesterone in serum, and increases the expression of vascular endothelial growth factor A upstream molecules estrogen and progesterone receptors in the endometrium. In addition, Bushen Tiaoxue Granules or Kunling Wan elevates the lysophosphatidic acid receptor 3 that participates in vascularization and increases the expression of leukemia inhibitory factor through up‐regulating the expression of p53 in the endometrium, ultimately affecting pregnancy outcome.
Conclusion
This study demonstrated Bushen Tiaoxue Granules or Kunling Wan as a potential strategy for prevention of impairment in angiogenesis and endometrial receptivity induced by controlled ovarian hyperstimulation.</description><identifier>ISSN: 1073-9688</identifier><identifier>EISSN: 1549-8719</identifier><identifier>DOI: 10.1111/micc.12581</identifier><identifier>PMID: 31313405</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Angiogenesis ; Animals ; Bushen Tiaoxue Granules ; controlled ovarian hyperstimulation ; Drugs, Chinese Herbal - pharmacology ; Embryo Implantation - drug effects ; Endometrium - blood supply ; Female ; Hormone replacement therapy ; Kunling Wan ; Neovascularization, Physiologic - drug effects ; Ovulation Induction ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; vascular dysfunction ; Vascular endothelial growth factor</subject><ispartof>Microcirculation (New York, N.Y. 1994), 2020-01, Vol.27 (1), p.e12581-n/a</ispartof><rights>2019 John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3571-c205ad07939bc681172dd43ca86888958ed12179b948c837d3a4528653c776423</citedby><cites>FETCH-LOGICAL-c3571-c205ad07939bc681172dd43ca86888958ed12179b948c837d3a4528653c776423</cites><orcidid>0000-0002-2286-8076</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fmicc.12581$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fmicc.12581$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31313405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lv, Bo‐Yang</creatorcontrib><creatorcontrib>Sun, Hao‐Yu</creatorcontrib><creatorcontrib>Li, Quan</creatorcontrib><creatorcontrib>Zhang, Hao‐Lin</creatorcontrib><creatorcontrib>Pan, Chun‐Shui</creatorcontrib><creatorcontrib>Yan, Li</creatorcontrib><creatorcontrib>Fan, Jing‐Yu</creatorcontrib><creatorcontrib>Li, Dong</creatorcontrib><creatorcontrib>Han, Jing‐Yan</creatorcontrib><title>The ameliorating effects of Bushen Tiaoxue Granules and Kunling Wan on impaired angiogenesis and endometrial receptivity in rats following controlled ovarian hyperstimulation</title><title>Microcirculation (New York, N.Y. 1994)</title><addtitle>Microcirculation</addtitle><description>Objective
To investigate the effects of Bushen Tiaoxue Granules and Kunling Wan, the two Chinese medicines, on vascular dysfunction and the impairment of endometrial receptivity caused by controlled ovarian hyperstimulation and its underlying mechanism.
Methods
Female Sprague Dawley rats with regular estrous cycle were enrolled and given Bushen Tiaoxue Granules or Kunling Wan by gavage for 12 days, and then, controlled ovarian hyperstimulation model was induced. We assessed endometrial microvessels, endometrial blood flow, levels of estradiol and progesterone in serum, vascular endothelial growth factor A upstream molecules estrogen and progesterone receptors in the endometrium, and pregnancy outcome.
Results
Pre‐treatment of Bushen Tiaoxue Granules or Kunling Wan increases endometrial blood flow of controlled ovarian hyperstimulation rats, up‐regulates vascular endothelial growth factor A and microvessels, improves the endometrial morphology of controlled ovarian hyperstimulation rats during implantation, decreases the super physiological concentration of estradiol and progesterone in serum, and increases the expression of vascular endothelial growth factor A upstream molecules estrogen and progesterone receptors in the endometrium. In addition, Bushen Tiaoxue Granules or Kunling Wan elevates the lysophosphatidic acid receptor 3 that participates in vascularization and increases the expression of leukemia inhibitory factor through up‐regulating the expression of p53 in the endometrium, ultimately affecting pregnancy outcome.
Conclusion
This study demonstrated Bushen Tiaoxue Granules or Kunling Wan as a potential strategy for prevention of impairment in angiogenesis and endometrial receptivity induced by controlled ovarian hyperstimulation.</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>Bushen Tiaoxue Granules</subject><subject>controlled ovarian hyperstimulation</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Embryo Implantation - drug effects</subject><subject>Endometrium - blood supply</subject><subject>Female</subject><subject>Hormone replacement therapy</subject><subject>Kunling Wan</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>Ovulation Induction</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>vascular dysfunction</subject><subject>Vascular endothelial growth factor</subject><issn>1073-9688</issn><issn>1549-8719</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFvFCEYhompsbV66Q9oSHozmQrDMMCx3WhtrPGyxuOEhW92aRgYYWbr_il_o6xTPQoHIDzf8xFehC4ouaZlvB-cMde05pK-QGeUN6qSgqqTsieCVaqV8hS9zvmRECJlrV6hU0bLbAg_Q7_WO8B6AO9i0pMLWwx9D2bKOPb4ds47CHjtdPw5A75LOsweMtbB4s9z8Ef8uw44BuyGUbsEttxtXdxCgOwWEIKNA0zJaY8TGBgnt3fTAbuAS8eM--h9fDqqTAxTKqdiiXtdCgLeHUZIeXLD7MvrYniDXvbaZ3j7vJ6jbx8_rFefqoevd_erm4fKMC5oZWrCtSVCMbUxraRU1NY2zGhZPkMqLsHSmgq1UY00kgnLdMNr2XJmhGibmp2jq8U7pvhjhjx1j3FOobTsasZaxVvGSaHeLZRJMecEfTcmN-h06CjpjtF0x2i6P9EU-PJZOW8GsP_Qv1kUgC7Ak_Nw-I-q-3K_Wi3S3yE8nGA</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Lv, Bo‐Yang</creator><creator>Sun, Hao‐Yu</creator><creator>Li, Quan</creator><creator>Zhang, Hao‐Lin</creator><creator>Pan, Chun‐Shui</creator><creator>Yan, Li</creator><creator>Fan, Jing‐Yu</creator><creator>Li, Dong</creator><creator>Han, Jing‐Yan</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-2286-8076</orcidid></search><sort><creationdate>202001</creationdate><title>The ameliorating effects of Bushen Tiaoxue Granules and Kunling Wan on impaired angiogenesis and endometrial receptivity in rats following controlled ovarian hyperstimulation</title><author>Lv, Bo‐Yang ; Sun, Hao‐Yu ; Li, Quan ; Zhang, Hao‐Lin ; Pan, Chun‐Shui ; Yan, Li ; Fan, Jing‐Yu ; Li, Dong ; Han, Jing‐Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3571-c205ad07939bc681172dd43ca86888958ed12179b948c837d3a4528653c776423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Bushen Tiaoxue Granules</topic><topic>controlled ovarian hyperstimulation</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Embryo Implantation - drug effects</topic><topic>Endometrium - blood supply</topic><topic>Female</topic><topic>Hormone replacement therapy</topic><topic>Kunling Wan</topic><topic>Neovascularization, Physiologic - drug effects</topic><topic>Ovulation Induction</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>vascular dysfunction</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lv, Bo‐Yang</creatorcontrib><creatorcontrib>Sun, Hao‐Yu</creatorcontrib><creatorcontrib>Li, Quan</creatorcontrib><creatorcontrib>Zhang, Hao‐Lin</creatorcontrib><creatorcontrib>Pan, Chun‐Shui</creatorcontrib><creatorcontrib>Yan, Li</creatorcontrib><creatorcontrib>Fan, Jing‐Yu</creatorcontrib><creatorcontrib>Li, Dong</creatorcontrib><creatorcontrib>Han, Jing‐Yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lv, Bo‐Yang</au><au>Sun, Hao‐Yu</au><au>Li, Quan</au><au>Zhang, Hao‐Lin</au><au>Pan, Chun‐Shui</au><au>Yan, Li</au><au>Fan, Jing‐Yu</au><au>Li, Dong</au><au>Han, Jing‐Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ameliorating effects of Bushen Tiaoxue Granules and Kunling Wan on impaired angiogenesis and endometrial receptivity in rats following controlled ovarian hyperstimulation</atitle><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle><addtitle>Microcirculation</addtitle><date>2020-01</date><risdate>2020</risdate><volume>27</volume><issue>1</issue><spage>e12581</spage><epage>n/a</epage><pages>e12581-n/a</pages><issn>1073-9688</issn><eissn>1549-8719</eissn><abstract>Objective
To investigate the effects of Bushen Tiaoxue Granules and Kunling Wan, the two Chinese medicines, on vascular dysfunction and the impairment of endometrial receptivity caused by controlled ovarian hyperstimulation and its underlying mechanism.
Methods
Female Sprague Dawley rats with regular estrous cycle were enrolled and given Bushen Tiaoxue Granules or Kunling Wan by gavage for 12 days, and then, controlled ovarian hyperstimulation model was induced. We assessed endometrial microvessels, endometrial blood flow, levels of estradiol and progesterone in serum, vascular endothelial growth factor A upstream molecules estrogen and progesterone receptors in the endometrium, and pregnancy outcome.
Results
Pre‐treatment of Bushen Tiaoxue Granules or Kunling Wan increases endometrial blood flow of controlled ovarian hyperstimulation rats, up‐regulates vascular endothelial growth factor A and microvessels, improves the endometrial morphology of controlled ovarian hyperstimulation rats during implantation, decreases the super physiological concentration of estradiol and progesterone in serum, and increases the expression of vascular endothelial growth factor A upstream molecules estrogen and progesterone receptors in the endometrium. In addition, Bushen Tiaoxue Granules or Kunling Wan elevates the lysophosphatidic acid receptor 3 that participates in vascularization and increases the expression of leukemia inhibitory factor through up‐regulating the expression of p53 in the endometrium, ultimately affecting pregnancy outcome.
Conclusion
This study demonstrated Bushen Tiaoxue Granules or Kunling Wan as a potential strategy for prevention of impairment in angiogenesis and endometrial receptivity induced by controlled ovarian hyperstimulation.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31313405</pmid><doi>10.1111/micc.12581</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-2286-8076</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1073-9688 |
| ispartof | Microcirculation (New York, N.Y. 1994), 2020-01, Vol.27 (1), p.e12581-n/a |
| issn | 1073-9688 1549-8719 |
| language | eng |
| recordid | cdi_proquest_journals_2336956350 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Angiogenesis Animals Bushen Tiaoxue Granules controlled ovarian hyperstimulation Drugs, Chinese Herbal - pharmacology Embryo Implantation - drug effects Endometrium - blood supply Female Hormone replacement therapy Kunling Wan Neovascularization, Physiologic - drug effects Ovulation Induction Pregnancy Rats Rats, Sprague-Dawley vascular dysfunction Vascular endothelial growth factor |
| title | The ameliorating effects of Bushen Tiaoxue Granules and Kunling Wan on impaired angiogenesis and endometrial receptivity in rats following controlled ovarian hyperstimulation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T09%3A09%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20ameliorating%20effects%20of%20Bushen%20Tiaoxue%20Granules%20and%20Kunling%20Wan%20on%20impaired%20angiogenesis%20and%20endometrial%20receptivity%20in%20rats%20following%20controlled%20ovarian%20hyperstimulation&rft.jtitle=Microcirculation%20(New%20York,%20N.Y.%201994)&rft.au=Lv,%20Bo%E2%80%90Yang&rft.date=2020-01&rft.volume=27&rft.issue=1&rft.spage=e12581&rft.epage=n/a&rft.pages=e12581-n/a&rft.issn=1073-9688&rft.eissn=1549-8719&rft_id=info:doi/10.1111/micc.12581&rft_dat=%3Cproquest_cross%3E2336956350%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2336956350&rft_id=info:pmid/31313405&rfr_iscdi=true |