Comparison of HLTV-I basal transcription and expression of CREB/ATF-1/CREM family members in peripheral blood mononuclear cells and Jurkat T cells

Comparison of HLTV-I basal transcription and expression of CREB/ATF-1/CREM family members in peripheral blood mononuclear cells and Jurkat T cells

HTLV-I is the etiologic agent of adult T-cell leukemia/lymphoma and is associated with tropical spastic paraparesis/HTLV-I-associated myelopathy. Following integration into the host cell genome, HTLV-I replication is regulated by both host and viral mechanisms that control transcription. Low levels...

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Veröffentlicht in:Journal of acquired immune deficiency syndromes (1999) 1999-01, Vol.20 (1), p.1
Hauptverfasser: Newbound, Garret C, O Rourke, John P, Collins, Nathaniel D, DeWille, James, Lairmore, Michael D
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Blood
Cells
Disease
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container_title Journal of acquired immune deficiency syndromes (1999)
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creator Newbound, Garret C
O Rourke, John P
Collins, Nathaniel D
DeWille, James
Lairmore, Michael D
description HTLV-I is the etiologic agent of adult T-cell leukemia/lymphoma and is associated with tropical spastic paraparesis/HTLV-I-associated myelopathy. Following integration into the host cell genome, HTLV-I replication is regulated by both host and viral mechanisms that control transcription. Low levels of viral transcription (basal transcription) occur before expression of the virally encoded Tax protein (Tax-mediated transcription).
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1944-7884
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source Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; Free E- Journals
subjects Blood
Cells
Disease
title Comparison of HLTV-I basal transcription and expression of CREB/ATF-1/CREM family members in peripheral blood mononuclear cells and Jurkat T cells
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