Rhesus macaques that became systemically infected with pathogenic SHIV 89.6-PD after intravenous, rectal, or vaginal inoculation and fail to make an antiviral antibody response rapidly develop AIDS
A new simian-human immunodeficiency virus (SHIV) stock (SHIV 89.6-PD), derived from plasma of a rhesus macaque used for in vivo serial passage of virulence-attenuated SHIV 89.6, produces systemic infection after intravenous, intravaginal, or intrarectal inoculation of rhesus macaques. Infection with...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 1998-09, Vol.19 (1), p.6 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
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| creator | Lu, Yichen Pauza, C David Lu, Xusheng Montefiori, David C Miller, Christopher J |
| description | A new simian-human immunodeficiency virus (SHIV) stock (SHIV 89.6-PD), derived from plasma of a rhesus macaque used for in vivo serial passage of virulence-attenuated SHIV 89.6, produces systemic infection after intravenous, intravaginal, or intrarectal inoculation of rhesus macaques. Infection with this virus results in high levels of viral antigen in plasma, a precipitous decline in CD4+ T-cell counts, and a disease syndrome that is characteristic of AIDS. |
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Infection with this virus results in high levels of viral antigen in plasma, a precipitous decline in CD4+ T-cell counts, and a disease syndrome that is characteristic of AIDS.</abstract><cop>Hagerstsown</cop><pub>Lippincott Williams & Wilkins Ovid Technologies</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1525-4135 |
| ispartof | Journal of acquired immune deficiency syndromes (1999), 1998-09, Vol.19 (1), p.6 |
| issn | 1525-4135 1944-7884 |
| language | eng |
| recordid | cdi_proquest_journals_233635653 |
| source | Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; Free E- Journals |
| subjects | Acquired immune deficiency syndrome AIDS HIV Human immunodeficiency virus Medical research Monkeys & apes |
| title | Rhesus macaques that became systemically infected with pathogenic SHIV 89.6-PD after intravenous, rectal, or vaginal inoculation and fail to make an antiviral antibody response rapidly develop AIDS |
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