Inhibition of HIV replication by sense and antisense Rev response elements in HIV-based retroviral vectors

The life cycle of HIV-1 is critically dependent on the transregulatory proteins Tat and Rev. Tat increases the production of HIV-specific mRNAs by direct binding to the transactivation response element, while Rev is required for the cytoplasmic expression of full-length mRNAs encoding Gag, Pol and E...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 1996-08, Vol.12 (4), p.343
Hauptverfasser:	Kim, Jerome H, McLinden, Robert J, Mosca, Joseph D, Vahey, Maryanne T
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Sprache:	eng
Schlagworte:	HIV Human immunodeficiency virus Medical research Proteins
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container_title	Journal of acquired immune deficiency syndromes (1999)
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creator	Kim, Jerome H McLinden, Robert J Mosca, Joseph D Vahey, Maryanne T
description	The life cycle of HIV-1 is critically dependent on the transregulatory proteins Tat and Rev. Tat increases the production of HIV-specific mRNAs by direct binding to the transactivation response element, while Rev is required for the cytoplasmic expression of full-length mRNAs encoding Gag, Pol and Env structural proteins.
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language	eng
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source	Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; Free E- Journals
subjects	HIV Human immunodeficiency virus Medical research Proteins
title	Inhibition of HIV replication by sense and antisense Rev response elements in HIV-based retroviral vectors
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