Identification of a Newly Characterized HIV-1 BG Intersubtype Circulating Recombinant Form in Galicia, Spain, Which Exhibits a Pseudotype-Like Virion Structure
We recently reported the finding of phylogenetically related HIV-1 BG intersubtype recombinant and G subtype nonrecombinant viruses circulating among injecting drug users in the region of Galicia in northwestern Spain. Here, we report the characterization of near full-length genome sequences of nine...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2002-04, Vol.29 (5), p.536-543 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
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| creator | Delgado, Elena Thomson, Michael M Villahermosa, María Luisa Sierra, María Ocampo, Antonio Miralles, Celia Rodríguez-Pérez, Raül Diz-Aren, Julio Ojea-de Castro, Rafael Losada, Elena Cuevas, María Teresa Vázquez-de Parga, Elena Carmona, Rocío Pérez-Álvarez, Lucía Medrano, Leandro Cuevas, Laureano Taboada, José Antonio Nájera, Rafael |
| description | We recently reported the finding of phylogenetically related HIV-1 BG intersubtype recombinant and G subtype nonrecombinant viruses circulating among injecting drug users in the region of Galicia in northwestern Spain. Here, we report the characterization of near full-length genome sequences of nine of these viruses (seven BG recombinant and two of nonrecombinant G subtype), obtained from epidemiologically unlinked individuals. Bootscan analysis reveals that six recombinant viruses share an identical mosaic structure, with two intersubtype breakpoints delimiting a B subtype segment comprising most of Env gp120 and the external portion of Env gp41, with the remaining portions of the genome being of subtype G, thus mimicking a pseudotype virion structure. The seventh BG recombinant virus exhibits breakpoints in env coincident with the other BG viruses but contains additional B subtype segments in gag and pol. In phylogenetic trees of complete genomes and of the B subtype segment of env, all seven BG viruses group in a monophyletic cluster. G subtype portions of the BG viruses group uniformly with the newly derived nonrecombinant G subtype viruses of Galicia in bootscan analysis, which points to the locally circulating G subtype strain as parental of the recombinants. These results allow us to define a new HIV-1 circulating recombinant form (CRFI4_BG), the first reported to originate in Western Europe. |
| doi_str_mv | 10.1097/00126334-200204150-00016 |
| format | Article |
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Here, we report the characterization of near full-length genome sequences of nine of these viruses (seven BG recombinant and two of nonrecombinant G subtype), obtained from epidemiologically unlinked individuals. Bootscan analysis reveals that six recombinant viruses share an identical mosaic structure, with two intersubtype breakpoints delimiting a B subtype segment comprising most of Env gp120 and the external portion of Env gp41, with the remaining portions of the genome being of subtype G, thus mimicking a pseudotype virion structure. The seventh BG recombinant virus exhibits breakpoints in env coincident with the other BG viruses but contains additional B subtype segments in gag and pol. In phylogenetic trees of complete genomes and of the B subtype segment of env, all seven BG viruses group in a monophyletic cluster. G subtype portions of the BG viruses group uniformly with the newly derived nonrecombinant G subtype viruses of Galicia in bootscan analysis, which points to the locally circulating G subtype strain as parental of the recombinants. These results allow us to define a new HIV-1 circulating recombinant form (CRFI4_BG), the first reported to originate in Western Europe.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/00126334-200204150-00016</identifier><identifier>PMID: 11981372</identifier><identifier>CODEN: JDSRET</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Biological and medical sciences ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Genome, Viral ; HIV ; HIV Envelope Protein gp120 - genetics ; HIV Envelope Protein gp41 - genetics ; HIV Infections - epidemiology ; HIV Infections - virology ; HIV-1 - classification ; HIV-1 - genetics ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Molecular Sequence Data ; Recombination, Genetic ; Sequence Analysis, DNA ; Spain - epidemiology ; Substance Abuse, Intravenous - complications ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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Here, we report the characterization of near full-length genome sequences of nine of these viruses (seven BG recombinant and two of nonrecombinant G subtype), obtained from epidemiologically unlinked individuals. Bootscan analysis reveals that six recombinant viruses share an identical mosaic structure, with two intersubtype breakpoints delimiting a B subtype segment comprising most of Env gp120 and the external portion of Env gp41, with the remaining portions of the genome being of subtype G, thus mimicking a pseudotype virion structure. The seventh BG recombinant virus exhibits breakpoints in env coincident with the other BG viruses but contains additional B subtype segments in gag and pol. In phylogenetic trees of complete genomes and of the B subtype segment of env, all seven BG viruses group in a monophyletic cluster. G subtype portions of the BG viruses group uniformly with the newly derived nonrecombinant G subtype viruses of Galicia in bootscan analysis, which points to the locally circulating G subtype strain as parental of the recombinants. These results allow us to define a new HIV-1 circulating recombinant form (CRFI4_BG), the first reported to originate in Western Europe.</description><subject>Biological and medical sciences</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genome, Viral</subject><subject>HIV</subject><subject>HIV Envelope Protein gp120 - genetics</subject><subject>HIV Envelope Protein gp41 - genetics</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - genetics</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Recombination, Genetic</subject><subject>Sequence Analysis, DNA</subject><subject>Spain - epidemiology</subject><subject>Substance Abuse, Intravenous - complications</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Virion</subject><subject>Virology</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kstu1DAUhiMEoqXwCshCYleDb7GTJYza6UgjQBTK0nJsh7jNOFNfNAwvw6viMANdsbJ99P3nHOlzVQGM3mDUircIYcIpZZAgRBDDNYKo1Pij6hS3jEHRNOxxudekhgzT-qR6FuPtTDDWPq1OMG4bTAU5rX6tjPXJ9U6r5CYPph4o8MHuxj1YDCoonWxwP60BV6sbiMH7JVj5Uoq5S_utBQsXdB5L1H8Hn62eNp3zyidwOYUNcB4s1ei0U-fgequcPwffBqcHcPFjcJ1LsYz6FG0209wLrt2dBTcuzGtcp5B1ysE-r570aoz2xfE8q75eXnxZXMH1x-Vq8W4NNWWCQ0OQbkzbdJwoZTQXje0FKQ9MUMc1I0Qr0SHR1jVh3Brd6JbhxiCmC4YxPateHfpuw3SfbUzydsrBl5GSUMopaZkoUHOAdJhiDLaX2-A2KuwlRnIWI_-Kkf_EyD9iSvTlsX_uNtY8BI8mCvD6CKio1dgH5bWLDxzlhJVNC8cO3G4aZxF3Y97ZIAerxjTI_30M-htPPKVe</recordid><startdate>20020415</startdate><enddate>20020415</enddate><creator>Delgado, Elena</creator><creator>Thomson, Michael M</creator><creator>Villahermosa, María Luisa</creator><creator>Sierra, María</creator><creator>Ocampo, Antonio</creator><creator>Miralles, Celia</creator><creator>Rodríguez-Pérez, Raül</creator><creator>Diz-Aren, Julio</creator><creator>Ojea-de Castro, Rafael</creator><creator>Losada, Elena</creator><creator>Cuevas, María Teresa</creator><creator>Vázquez-de Parga, Elena</creator><creator>Carmona, Rocío</creator><creator>Pérez-Álvarez, Lucía</creator><creator>Medrano, Leandro</creator><creator>Cuevas, Laureano</creator><creator>Taboada, José Antonio</creator><creator>Nájera, Rafael</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>20020415</creationdate><title>Identification of a Newly Characterized HIV-1 BG Intersubtype Circulating Recombinant Form in Galicia, Spain, Which Exhibits a Pseudotype-Like Virion Structure</title><author>Delgado, Elena ; Thomson, Michael M ; Villahermosa, María Luisa ; Sierra, María ; Ocampo, Antonio ; Miralles, Celia ; Rodríguez-Pérez, Raül ; Diz-Aren, Julio ; Ojea-de Castro, Rafael ; Losada, Elena ; Cuevas, María Teresa ; Vázquez-de Parga, Elena ; Carmona, Rocío ; Pérez-Álvarez, Lucía ; Medrano, Leandro ; Cuevas, Laureano ; Taboada, José Antonio ; Nájera, Rafael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3476-d20c8d98b62aadc678ef7262a120b6c422ca7b07955246edc8c9418d04c726113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genome, Viral</topic><topic>HIV</topic><topic>HIV Envelope Protein gp120 - genetics</topic><topic>HIV Envelope Protein gp41 - genetics</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - classification</topic><topic>HIV-1 - genetics</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Recombination, Genetic</topic><topic>Sequence Analysis, DNA</topic><topic>Spain - epidemiology</topic><topic>Substance Abuse, Intravenous - complications</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Virion</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delgado, Elena</creatorcontrib><creatorcontrib>Thomson, Michael M</creatorcontrib><creatorcontrib>Villahermosa, María Luisa</creatorcontrib><creatorcontrib>Sierra, María</creatorcontrib><creatorcontrib>Ocampo, Antonio</creatorcontrib><creatorcontrib>Miralles, Celia</creatorcontrib><creatorcontrib>Rodríguez-Pérez, Raül</creatorcontrib><creatorcontrib>Diz-Aren, Julio</creatorcontrib><creatorcontrib>Ojea-de Castro, Rafael</creatorcontrib><creatorcontrib>Losada, Elena</creatorcontrib><creatorcontrib>Cuevas, María Teresa</creatorcontrib><creatorcontrib>Vázquez-de Parga, Elena</creatorcontrib><creatorcontrib>Carmona, Rocío</creatorcontrib><creatorcontrib>Pérez-Álvarez, Lucía</creatorcontrib><creatorcontrib>Medrano, Leandro</creatorcontrib><creatorcontrib>Cuevas, Laureano</creatorcontrib><creatorcontrib>Taboada, José Antonio</creatorcontrib><creatorcontrib>Nájera, Rafael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delgado, Elena</au><au>Thomson, Michael M</au><au>Villahermosa, María Luisa</au><au>Sierra, María</au><au>Ocampo, Antonio</au><au>Miralles, Celia</au><au>Rodríguez-Pérez, Raül</au><au>Diz-Aren, Julio</au><au>Ojea-de Castro, Rafael</au><au>Losada, Elena</au><au>Cuevas, María Teresa</au><au>Vázquez-de Parga, Elena</au><au>Carmona, Rocío</au><au>Pérez-Álvarez, Lucía</au><au>Medrano, Leandro</au><au>Cuevas, Laureano</au><au>Taboada, José Antonio</au><au>Nájera, Rafael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of a Newly Characterized HIV-1 BG Intersubtype Circulating Recombinant Form in Galicia, Spain, Which Exhibits a Pseudotype-Like Virion Structure</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>2002-04-15</date><risdate>2002</risdate><volume>29</volume><issue>5</issue><spage>536</spage><epage>543</epage><pages>536-543</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><coden>JDSRET</coden><abstract>We recently reported the finding of phylogenetically related HIV-1 BG intersubtype recombinant and G subtype nonrecombinant viruses circulating among injecting drug users in the region of Galicia in northwestern Spain. Here, we report the characterization of near full-length genome sequences of nine of these viruses (seven BG recombinant and two of nonrecombinant G subtype), obtained from epidemiologically unlinked individuals. Bootscan analysis reveals that six recombinant viruses share an identical mosaic structure, with two intersubtype breakpoints delimiting a B subtype segment comprising most of Env gp120 and the external portion of Env gp41, with the remaining portions of the genome being of subtype G, thus mimicking a pseudotype virion structure. The seventh BG recombinant virus exhibits breakpoints in env coincident with the other BG viruses but contains additional B subtype segments in gag and pol. In phylogenetic trees of complete genomes and of the B subtype segment of env, all seven BG viruses group in a monophyletic cluster. G subtype portions of the BG viruses group uniformly with the newly derived nonrecombinant G subtype viruses of Galicia in bootscan analysis, which points to the locally circulating G subtype strain as parental of the recombinants. These results allow us to define a new HIV-1 circulating recombinant form (CRFI4_BG), the first reported to originate in Western Europe.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>11981372</pmid><doi>10.1097/00126334-200204150-00016</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of acquired immune deficiency syndromes (1999), 2002-04, Vol.29 (5), p.536-543 |
| issn | 1525-4135 1944-7884 |
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| subjects | Biological and medical sciences Epidemiology Female Fundamental and applied biological sciences. Psychology Genome, Viral HIV HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp41 - genetics HIV Infections - epidemiology HIV Infections - virology HIV-1 - classification HIV-1 - genetics Human immunodeficiency virus Human viral diseases Humans Infectious diseases Male Medical sciences Microbiology Molecular Sequence Data Recombination, Genetic Sequence Analysis, DNA Spain - epidemiology Substance Abuse, Intravenous - complications Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virion Virology |
| title | Identification of a Newly Characterized HIV-1 BG Intersubtype Circulating Recombinant Form in Galicia, Spain, Which Exhibits a Pseudotype-Like Virion Structure |
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