Inhibition of PLK1 by capped‐dose volasertib exerts substantial efficacy in MDS and sAML while sparing healthy haematopoiesis

Introduction Targeting the cell cycle machinery represents a rational therapeutic approach in myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (sAML). Despite substantial response rates, clinical use of the PLK inhibitor volasertib has been hampered by elevated side effects such...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of haematology 2020-02, Vol.104 (2), p.125-137
Hauptverfasser:	Dill, Veronika, Kauschinger, Johanna, Hauch, Richard T., Buschhorn, Lars, Odinius, Timo O., Müller‐Thomas, Catharina, Mishra, Ritu, Kyncl, Michele C., Schmidt, Burkhard, Prodinger, Peter M., Hempel, Dirk, Bellos, Frauke, Höllein, Alexander, Kern, Wolfgang, Haferlach, Torsten, Slotta‐Huspenina, Julia, Bassermann, Florian, Peschel, Christian, Götze, Katharina S., Waizenegger, Irene C., Höckendorf, Ulrike, Jost, Philipp J., Jilg, Stefanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Adult Aged Aged, 80 and over Bone marrow Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Cell cycle Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - metabolism Cell death Cell survival Colonies Female Flow cytometry Gene Expression Regulation, Leukemic - drug effects Hematopoiesis - drug effects Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Leukocytes (mononuclear) Male Myelodysplastic syndrome myelodysplastic syndromes (MDS) Myelodysplastic Syndromes - drug therapy Myelodysplastic Syndromes - metabolism Myelodysplastic Syndromes - pathology Myeloid Cell Leukemia Sequence 1 Protein - biosynthesis Myeloid leukemia Neutropenia Patients PLK1 Polo-Like Kinase 1 Progenitor cells Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - metabolism Pteridines - administration & dosage Pteridines - adverse effects Receptor-Interacting Protein Serine-Threonine Kinases - biosynthesis secondary acute myeloid leukemia (sAML) Stem cells volasertib
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!